COT/COM/COC Annual Report Index

T - Index

Last updated: 11 January 2024

In this guide

Subject: Terephthalic acid	Year	Page
In vitro and in vivo mutagenicity	2001	87
endocrine disrupting effects, urinary bladder and the kidney	2003	13
In vivo mutagenicity	2007	135
TDI and updated COT statement on	2008	16
and isophthalic acids in food	2000	24
multigenerational reproduction study additional histopathological examinations	2005	10
Update statement on the Toxicology of	2008	21

Subject:

Toxins

Year

Page

T2-toxin and HT2-toxin and neosolaniol in the diet of infants aged 0-1 and young children aged 1-5 years.

2018

Subject: Test strategies and evaluations	Year	Page
Continued advice, OECD recommendations, standardisation of genotoxicity test procedures	1993	39
finalise the updating of 7 existing guidelines and to consider 2 new guidelines.	1994	25
interpretation of genotoxicity tests chemical mutagenesis	1995	37
advice on strategies in carcinogenicity for the ongoing discussions of the International Conference on	1996	44
Harmonisation of the Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH).	1996	75
test strategies and interpretation of genotoxicity tests in the context of the discussions of the Genotoxicity Working Party of the International Conference on Harmonisation of the Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH).	1997	75, 112
review of its guidelines for the testing of chemicals for mutagenicity	1998	34, 50
revision of guidelines on an appropriate strategy for the testing of chemicals for mutagenicity & evaluation of chemically induced aneuploidy and in particular the extrapolation of data from somatic cells to germ cells.	2000	63
In vitro micronucleus test	2002	88
ILSI/HESI research programme on alternative cancer models: results of Syrian hamster embryo cell transformation assay	2002	87
IGHRC paper on uncertainty factors	2002	129
Minimum duration of carcinogenicity studies in rats	2002	130
Short term tests for carcinogenicity. (ILSI/HESI research programme on alternative cancer models)	2002	131
The investigation of interaction between genotype and chemicals in the environment on the induction of cancer	2002	132
In-vitro Mammalian cell mutation assays	2003	137
Strategy for investigating germ cell mutagens	2003	138
Significance of in-vivo mutagenicity at high doses	2003	139
COC guidance on a strategy for risk assessment of carcinogens	2004	188 to 190
COT/COC/COM review of toxicogenomics	2004	190, 191
approaches to test strategies for chemicals which were positive in in vitro mutagenicity tests	2006	240
TK6 GADD45a GFP genotoxicity assay as an early screening assay to be undertaken prior to in-vitro mutagenicity testing.	2007	137
development of an OECD guideline for the in vitro micronucleus test	2007	137
Review of COM Guidance 2000	2008	234
Risk assessment of in-vivo mutagens (and genotoxic carcinogens)	2001	89
Tobacco induced lung carcinogenesis: The importance of p53 mutations	2001	89
International Workshop on the Categorisation of Mutagens	2001	90

Subject:

Testicular cancer

Year

Page

Review of the possible chemical aetiology of,

2006

284

Subject: 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)	Year	Page
as a possible human carcinogen	1993	49
Developmental and reproductive toxicity, Immunotoxicity, Carcinogenicity, Exposure from human milk	1995	15, 64
Review, Consideration of IARC Monograph Published in 1997	1998	45
review of the relevant literature published since 1990	1999	49
Carcinogenicity of	2001	115

Subject: Tetrabromobisphenol A (TBBPA)	Year	Page
Tetrabromobisphenol A	2004	12
review of toxicological data	2004	62
in the infant diet	2014	19

Subject: Tetrachloroethylene	Year	Page
Perchloroethylene, risk of developmental toxicity	1993	21, 48
review the animal and human carcinogenicity data on this compound with particular reference to the recent epidemiology	1996	37, 68
reproductive and developmental toxicity arising from exposure to	1997	47

Subject:

Thalidomide

Year

Page

Mutagenicity of,

1997

Subject: Thiabendazole	Year	Page
development of the fetus	1991	20
developmental toxicity	1995	20
as a potential in-vivo aneugen	1996	40
COT evaluation of ; ADI	1997	50

Subject:

Thiamphenicol

Year

Page

potential to cause idiopathic blood dyscrasia

1992

Subject: Thresholds for aneuploidy inducing chemicals	Year	Page
in-vivo assays	1995	37
Studies on Benomyl and Carbendazim	1996	42
Thresholds for in vivo mutagens	2009	151
Threshold for benzene induced carcinogenicity, Consideration of evidence for	1998	32

Subject:

Titanium dioxide

Year

Page

Review of 2021 EFSA opinion

2021

23, 60

Interim position paper, ongoing work

2021

Subject: Tobacco	Year	Page
toxicological evaluation of tobacco, ingredients and additives used in the manufacture of tobacco, and its emission products.	2008	14
genotoxicity of	2009	53
Reassessment of the toxicological testing of tobacco	2004	19, 107,
Reassessment of toxicology of tobacco products	2004	142, 186
Carcinogenicity testing of	2009	219
reassessment of the toxicological testing of	2004	19, 107
reassessment of the toxicology of	2004	142, 186
Tobacco induced lung carcinogenesis: the importance of p53 mutations	2001	107

Subject:

Toltrazuril

Year

Page

Advice on,

1992

Subject: Toxicity of chemicals in the infant diet; and the diet of young children aged 1 to 5 years	Year	Page
Aluminium, lead, vitamin A, soy phytoestrogens	2012	22
α-, β- and γ-hexachlorocyclohexanes and perfluorooctane sulphonate	2013	32
Reviews of vitamin A, iodine and nickel commenced in 2016 and will continue in 2017	2016	22
manganese, chromium and copper	2017	27
Mycotoxins were reviewed in 2017 and full reviews of T2,HT2 and neosolaniol and ochratoxin A commenced in 2017.	2017	27
Statements on nickel and cadmium had been finalised in 2017	2017	28

Subject: Toxicogenomics	Year	Page
in toxicology, ongoing review of new relevant in vitro studies	2007	137, 185
COM ongoing review	2008	235
COT/COC/COM update their joint statement on toxicogenomics published in 2004	2009	60
as a tool for identifying genotoxic carcinogens	2013	46
use of in toxicology (update on statement published in 2002)	2004	22, 112
COT/COC/COM review of	2004	144
in toxicology – design, analysis and statistical issues	2010	29
Toxicological aspects of the SACN report on Iron	2009	29
In toxicology testing, presentation on	2021	58
Toxicological evaluation of chemical analyses carried out as part of a pilot study for a breast milk archive	2004	14, 70
Toxicogenomics data in risk assessment	2012	16
ToxTracker	2019	34, 52
Transgenerational Epigenetics, Workshop on	2008	19, 36
Use of toxicogenomics in toxicology (update on statement published in 2002).	2004	22, 112

Subject:

Transgenerational Epigenetics

Year

Page

Workshop and implications for risk assessment

2008

19,36

Environmental toxicant induced, presentation on

2021

Subject: Transgenic animal models	Year	Page
Transgenic animal models, Use in short terms tests for carcinogenicity	2001	142
Transgenic mouse models	1997	114
Validation of short-term carcinogenicity tests using transgenic animals, Presentation on	1999	73

Subject:

Trichloroethylene

Year

Page

Trichloroethylene

1996

39, 71

Subject:

Trihalomethanes in drinking water

Year

Page

Chloroform, Bromodichloromethane [BDCM], Chlorodibromomethane [DBCM] and Bromoform

1994

22, 32, 69

Bromodichloromethane, Chlorodibromomethane, and Bromoform.

1995

Subject:

Tryptophan and eosinophilia-myalgia syndrome

Year

Page

risk to health of tryptophan, particularly in food supplements

2003

one or more contaminants in several batches of tryptophan produced by one manufacturer

2004

12, 83

Subject:

Tryptophan in food

Year

Page

responses to consultation on revision of Regulations

2005

Subject:

Turmeric

Year

Page

supplements- potential; hepatotoxicity of

2019

Subject:

Type 1 caramel

Year

Page

Mutagenicity data,

1991

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T - Index

In this guide

On this page

Terephthalic acid

Toxins

Test strategies and evaluations

Testicular cancer

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)

Tetrabromobisphenol A (TBBPA)

Tetrachloroethylene

Thalidomide

Thiabendazole

Thiamphenicol

Thresholds for aneuploidy inducing chemicals

Titanium dioxide

Tobacco

Toltrazuril

Toxicity of chemicals in the infant diet;

and the diet of young children aged 1 to 5 years

Toxicogenomics

Transgenerational Epigenetics

Transgenic animal models

Trichloroethylene

Trihalomethanes in drinking water

Tryptophan and eosinophilia-myalgia syndrome

Tryptophan in food

Turmeric

Type 1 caramel

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