COT/COM/COC Annual Report Index

G - Index

Last updated: 11 January 2024

Subject:

GADD45a GFP ‘Green Screen’ assay

Year

Page

COM Discussion of

2010

42

Subject:

Gallates (anti-oxidants in food)

Year

Page

COM Discussion of

1992

37

Subject:

Gellan gum

Year

Page

COT Evaluation of

1993

13

Subject:

Genetically modified

Year

Page

Potatoes genetically modified to produce Galanthus nivalis

Lectin

1999

34

Subject:

Genetic susceptibility to cancer

Year

Page

COC/COM Joint Symposium on

1998

33

Joint COC/COM symposium on genetic susceptibility to

cancer

1998

35

COC scoping discussion on,

2000

110

Subject:

Genomics and proteomics in toxicology, Joint meeting of COT/COC/COM on

Year

Page

assessing their current and future potential as tools in regulatory risk assessments.

2001

 

24, 109,

143

use of genomics and proteomics in toxicology

2002

14

Subject:

Genotoxic Consequences of Exposure to Mixtures of Food Derived Chemical Carcinogens

Year

Page

COM review of FSA funded research on

2012

39

Subject:

Genotoxic alkylating agents

Year

Page

Thresholds for

2006

237

Subject:

Genotoxic carcinogens

Year

Page

and DNA repair at low doses

2004

136, 176

Acute T25 – possible approach to potency ranking of single exposure

2006

279

The occurrence of “U” shaped dose dose-response curves

2003

196

European Food Safety Authority (EFSA) Advice to- chemicals that are genotoxic and carcinogenic

2005

141

Genotoxicity Testing of Impurities

2011

44

Interim Guidance on a Strategy for Genotoxicity Testing and  Assessment of Impurities

2012

35

Subject:

Genotoxicity data

Year

Page

Interpretation of, two-day 2019 workshop on

2020

48

Subject:

Genotoxicity, evidence for

Year

Page 

Genotoxicity testing and mutagenic hazard assessment of chemical substances.  Consultation on a strategy for

2010

48

consolidated summary of discussions

2017

42

Subject:

Genotoxicity of Nanomaterials

Year

Page

A COM statement is currently being drafted

2011

45

in vitro genotoxicity testing of nanomaterials

2012

36

Subject:

Genotoxicity of water and wastewater

Year

Page

ISO Water quality standard: Determination of the genotoxicity of water and waste water using the umu test

1997

69

Subject:

Genotype and environment interaction on susceptibility to cancer

Year

Page

COC review of

2001

121

The investigation of interaction between genotype and chemicals in the environment on the induction of cancer

2002

132

Genotypes and chemicals in the environment on the induction of cancer in risk assessment. Interaction between

2010

59

Subject:

Germ cell mutagenesis

Year

Page

investigating germ cell mutagenesis, the germ cell genome, meiosis and mutagenesis, the paternal age effect and aneuploidy in germ cells

2015

38

adverse outcome pathways

2016

34

consolidated summary of discussions

2017

43

Strategy for investigating germ cell mutagens

2003

138

Germ cell mutagens, COM guidance on testing

2021

53

Subject:

Ginger

Year

Page

ongoing work on the COT contribution to the SACN risk assessment on nutrition and, ginger

2021

33

Subject:

Glucosamine and hepatotoxicity

Year

Page

a very small number of individual case reports linking glucosamine and hepatitis

2008

20

case reports linking glucosamine and hepatitis

2009

15, 38

Subject:

Gluten – timing of introduction into the infant diet

Year

Page

and subsequent risk of developing coeliac disease or type 1 diabetes mellitus (T1DM)

2010                        

27

Further discussions on subsequent risk of developing coeliac disease or type 1 diabetes mellitus (T1DM)

2011

11

Subject:

Guidance statement on the human health significance of chemical induced mutagenicity

Year

Page

joint COC, COM and COT workshop on ‘Whether epigenetics should be used in chemical risk assessment’

2017

55

information on chemically induced mutagenesis relevant to human health to the informed lay reader.

2013

45, 59

Subject:

Guidance statements, COC

Year

Page

Mode of Action, Human Relevance Framework and Margin of Exposure

2011

58

overarching statement G1, a statement on risk characterisation methods for carcinogens

2012

48

Overarching strategy (GO1)

2019

53

Guidance statement update

2020

65

Guidance statement update on the use of biomarkers in carcinogenic risk assessment (G04)

2018

 

52

 

Hazard identification and characterisation: conduct and interpretation of animal carcinogenicity studies (G03), update of

2021

80

Guidance statement update

2018

52

Defining a point of departure and potency estimates in carcinogenic dose response (G05)

2018

52

Guidance statement update

2018

52

Further discussion papers on

2019

53

Risk characterisation methods (G06)

2018

52

Risk characterisation methods (G06) update of

2021

80

Alternatives to the 2-year bioassay (G07)

2018

52

Combined exposure to chemical carcinogens (GO8)

2019

54

Less than lifetime exposure (GO9)

2019

54

Subject:

Guidance statements, COM

Year

Page

Guidance on use of (Q)SAR models to predict genotoxicity, evaluation of in vivo genotoxicity

2018

40

Guidance on Mutagenic Hazard Assessment and a Strategy for Genotoxicity Testing of Chemicals with Inadequate Genotoxicity Data

2011

43

Guidance on the use of (Q)SAR models to predict genotoxicity

2018

40

Guidance series, COM update of

2019

34

Guidance series, COM update of

2020

47

Guidance series, COM update of

2021

53

Guidance on assessment strategies and genotoxicity tests

2010

41

ICH guidelines:  Genotoxicity: A standard battery for genotoxicity testing of pharmaceuticals (S2B) and consideration of the mouse lymphoma assay

 

1997

 

75

Germ cell mutagens, guidance on

2021

53

3D models, guidance on

2021

53

Testing strategies for nanomaterials, guidance on

2021

54

Testing strategies for impurities, update on guidance

2021

54

Use of QSAR models, guidance on

2021

54

Subject:

Gut microbiome

Year

Page

effects of xenobiotics on

2019

15

statement on the effect of xenobiotics on the gut microbiome and the effect the gut microbiome on xenobiotics with reference to chemical risk assessment

2020

11