Benchmark Dose Modelling in a UK Chemical Risk Assessment Framework

List of Abbreviations

Annex A

Last updated: 26 February 2026

ADI

Acceptable Daily Intake

AIC

Akaike Information Criterion

BMA

Bayesian Model Averaging

BMD

Benchmark Dose

BMDL

Benchmark Dose lower bound

BMDS

Benchmark Dose Software

BMDU

Benchmark Dose upper bound

BMR

Benchmark response

CED

Critical Effect Dose

CEDL

Critical Effect Dose lower bound

CEDU

Critical Effect Dose upper bound

CES

Critical Effect Size

COC

The Committee on Carcinogenicity of Chemicals in Food, Consumer Products and the Environment

COM

The Committee on Mutagenicity of Chemicals in Food, Consumer Products and the Environment

COT

The Committee on the Toxicity of Chemicals in Food, Consumer Products and the Environment

DRM  

Dose-Response Models

EFSA

European Food Safety Authority

FAO

Food and Agriculture Organization

FSA

Food Standards Agency

HBGV

Health Based Guidance Values

IPCS

International Programme on Chemical Safety

IRIS

Integrated Risk Information System

JECFA

Joint FAO/WHO Expert Committee on Food Additives

JMPR

Joint FAO/WHO Meeting on Pesticide Residues

LMS

Linearised Multistage (model)

LOAEL

Lowest Observed Adverse Effect Level

LVM

Latent variable model

MCMC

Markov Chain Monte Carlo

MLE

Maximum-Likelihood Estimation

MOE

Margin of Exposure

NOAEL

No Observed Adverse Effect Level

OECD

Organisation for Economic Co-operation and Development

OGD

Other Government Departments

PoD

Point of Departure

RfD

Reference Dose

RPF

Relative Potency Factors

SC

Scientific Committee

TEF

Toxic Equivalency Factors

UF

Uncertainty Factor

US EPA

United States Environmental Protection Agency

US NTP

United States National Toxicology Program

WHO

World Health Organisation