In this guide

Annex A to TOX/2026/12 - Fluoridation literature search proposal development

Key search 2 - Initial search 2022_Animal studies (PubMed)

Annex A to TOX/2026/12

Last updated: 24 March 2026

In this guide

This is a paper for discussion. This does not represent the views of the Committee and should not be cited.

17.             Literature search date: 22nd March 2022 (updated January 2024 (presumably 24th)2).

18.             Search concept: Fluorides AND adverse outcomes AND animals NOT Perfluoride NOT sulfuryl fluoride (see below for further details).

19.             Chemical search terms (fluorides concept): see Key search 1.

20.             Adverse outcomes concept: see Key search 1.

21.             Animals concept: "Animals, Laboratory"[Mesh] OR "Dogs"[Mesh] OR "Guinea Pigs"[Mesh:noExp] OR "Mice"[Mesh] OR "Primates"[Mesh:noExp] OR "Rabbits"[Mesh] OR "Rats"[Mesh] OR "Rodentia"[Mesh:noexp] OR "Swine"[Mesh] OR Dog[tiab] OR Dogs[tiab] OR "Laboratory animal*"[tiab] OR Mice[tiab] OR Monkey[tiab] OR Monkeys[tiab] OR Mouse[tiab] OR Pig[tiab] OR Pigs[tiab] OR Primate[tiab] OR Primates[tiab] OR Rabbit[tiab] OR Rabbits[tiab] OR Rat[tiab] OR Rats[tiab] OR Rodent*[tiab] OR Swine[tiab].

22.             Terms excluded: Perfluor*[tiab] OR "sulfuryl fluoride" [Supplementary Concept] OR "Sulfuryl fluoride"[tiab] OR "sulfonyl fluoride"[tiab] OR Vikane[tiab].