HRB (2022)

This is a paper for discussion. This does not represent the views of the Committee and should not be cited.

75.             Key endpoints covered: neuropsychological outcomes, bone health, and endocrine conditions (including thyroid function).

76.             Databases: Ovid MEDLINE, Ovid Embase, Cochrane Library (John Wiley & Sons Inc), Latin American and Caribbean Health Sciences Literature (LILACS), Epistemonikos (Epistemonikos Foundation), PROSPERO (University of York), and Cochrane CENTRAL (John Wiley & Sons Inc).

Key search 1 - PubMed

77.             Literature search date: 19 May 2021 (updated 28 September 2021).

78.             Search concept: Fluorides AND water AND human (see below for further details).

79.             Chemical search terms (fluorides concept): ((fluorid* or fluorin* or flurid* or florin*).mp[12]./) OR ((fluorid* or fluorin* or flurid* or florin*).sh[13].) OR (exp[14] Fluoride/ or exp Fluorides/ or exp Fluoridation/ or exp Fluorine/).

80.             Water concept: (exp Water/ or exp Water Supply/) OR water.mp.

81.             Human concept: blind*.mp. OR Case-Control Studies/ OR case-control.mp. OR ("case series" or "time series" or "before and after").mp. OR Cohort Studies/ OR cohort analysis/ OR cohort*.mp. OR control*.mp. OR clinical trial/ OR Cohort Studies/ OR cross over.mp. OR crossover.mp. OR crossover.mp. OR cross sectional.mp. OR double-blind method/ OR doubl*.mp. OR exp clinical trial/ OR comparative study/ OR comparative stud*.mp. OR controlled clinical trial/ OR Correlation study/ OR cross sectional study/ OR Ecological study/ or ecological stud*.mp. or ecological study.mp. OR evaluation study/ OR evaluation stud*.mp. OR Follow-Up Studies/ or followup.mp. or follow-up.mp. OR (health* adj2 survey*).mp. OR Incidence/ OR incidence.mp. OR mask*.mp. OR Mortality/ OR mortality.tw[15]. OR observational study/ OR Placebos/ OR placebo*.mp. OR predict*.mp. OR Prevalence/ OR prevalence.mp. OR prognos*.mp OR random*.mp. OR Randomized Controlled Trial/ OR random allocation/ OR risk.mp. OR exp Research Design/ OR Single-Blind Method/ OR singl*.mp. OR trebl*.mp. OR tripl*.mp. OR volunteer*.mp.

82.             Exclusion: not (exp animals/ not humans.sh.).

[12] Multi-purpose.

[13] Subject heading.

[14] Exploded subject heading.

[15] Text word.