EFSA Draft opinion on Δ⁸-THC – Derivation of a Health Based Guidance Value Δ⁸-THC

Discussion

TOX/2025/33

Last updated: 01 September 2025

This is a paper for discussion. This does not represent the views of the Committee and should not be cited.

   78.            The Secretariat have noted the following points.

   79.            The ARfD set by the EFSA panel of 1 μg/kg bw/day is for the sum of Δ⁸-THC and Δ9-THC. Therefore, this is a reduction in the EFSA current standing ARfD for Δ9-THC/Δ9-THCa at 1μg /kg bw. E.g. 0.5 μg of Δ⁸-THC + 0.5 Δ9-THC or 0.6 μg of Δ⁸-THC + 0.4 Δ9-THC.

   80.            No mention has been made of other precursors or other cannabinoids within this reference value (e.g. THCA).

   81.            The Secretariat noted the vast limitations in analytical data and sensitivity on detection methods. Therefore, occurrence calculations may not be reflective of actual human exposure to Δ⁸-THC in food.