EFSA Draft opinion on Δ⁸-THC – Derivation of a Health Based Guidance Value Δ⁸-THC

List of Abbreviations

TOX/2025/33

Last updated: 01 September 2025

This is a paper for discussion. This does not represent the views of the Committee and should not be cited.

Abbreviation

Definition

ACMD

Advisory Council on the Misuse of Drugs

ADME

Absorption, distribution, metabolism, and excretion

ARfD

Acute reference dose

AUC

Area under the curve

CBD

Cannabidiol

CBN

Cannabinol

CME

crude marihuana extract

CNS

Central nervous system

CONTAM

The Panel on Contaminants in the Food Chain

CYP

Cytochrome

DHT

Dihydrotestosterone

EC

European commission

ED50 

Effective dose 50%

EFSA

European food safety authority

FDA

USA Food and drug administration

FEEDAP

EFSA’s Panel on Additives and Products or Substances used in Animal Feed

FSH

Follicle-stimulating hormone

GC

Gas chromatography

GRAS

Generally Recognised as Safe

HBGV

Health-based guidance value

HEK

Human Embryonic Kidney

i.p.

Intraperitoneal 

LB

Lower bound

LC-MS/MS

Liquid chromatography/mass spectrometry 

LD50

Lethal dose 50%

LH

Luteinising hormone

LOAEL

Lowest observed adverse effect level

LOD

Limit of detection

LOQ

Limit of quantification

NOAEL

No observed adverse effect level

PMTDI

Provisional Maximum Tolerable Daily Intake

QSAR

Quantitative structure–activity relationship

SD

Significant difference

THC

Tetrahydrocannabinol

UB

Upper bound

UF

Uncertainty factor

THCA

Tetrahydrocannabinolic acid