New Approach Methodologies (NAMs) In Regulatory Risk Assessment Workshop Report 2020- Exploring Dose Response

Abbreviations - 2020 Workshop Report

Last updated: 28 February 2024

3Rs

Replacement, Reduction and Refinement

AI

Artificial intelligence

AOPs

Adverse outcome pathways

ATMP

Advanced therapy medical products

BEIS

Department for Business, Energy and Industrial Strategy

CONTAM

Scientific Panel on Contaminants in the Food chain

COT

Committee on Toxicity of Chemicals in Food, Consumer Products and the Environment

EFSA

European Food Safety Authority

EURL ECVAM

EU Reference Laboratory for alternatives to animal testing

ENM

Engineered nanomaterial

FDA

Food and Drug Administration

HBM4EU

Human biomonitoring 4 EU programme

HTS

High Throughput Screening

HTTr

High throughput transcriptomic

IATAs

Integrated approaches to testing and assessment

JRC

Joint Research Centre

LoD

Limit of Detection

LoQ

Limit of Quantitation

MIEs

Molecular-initiating events

NAMs

New Approach Methodologies

NBM

Nanobiomaterials

NC3Rs

National Centre for the Replacement, Refinement and Reduction of Animals in Research

NHANES     

National Health and Nutrition Examination Survey

NGRA

Next Generation Risk Assessment

NOTEL

No Observed Transcription Effect Level

OECD

Organisation for Economic Co-operation and Development

PET

Polyethylene terephthalate

PBPK

Physiologically based pharmacokinetics

PK

Pharmacokinetic

PD

Pharmacodynamic

POD

Points of departures

SAR

Structure-activity relationships

SARMs

Selective androgen receptor modulators

SEAC

Safety & Environmental Assurance Centre

SERD

Science, Evidence and Research Division

TAs

Tropane alkaloids

UK

United Kingdom

UK FSA

UK Food Standards Agency

US

United States

WoE

Weight of Evidence

VAM  

Vinyl acetate monomer

QSARs

Quantitative Structure Activity Relationships