PFAS/2023/02

PFAS/2023/02 Annex 1

PFAS/2023/02 Annex 1

Last updated: 31 October 2024

Reliability scoring

 Should papers undergo reliability scoring or quality assessment to assess reliability prior to inclusion into the narrative/table? The subgroup may wish to consider providing specific guidance on epidemiology, in vivo and in vitro studies, respectively?

To ensure data used in all reports are of adequate quality all in vivo and in vitro papers could undergo Klimisch scoring using the ToxRTool (Figure 1). Similarly, epidemiology data could undergo quality assessment e.g. using Newcastle Ottowa Score (NOS) (Figure 2), or Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) assessment (Figure 3), or based on Annex 1 of the SETE report..

Screening papers for reliability could reduce the number of papers used in the assessments and may impact on the subgroup decision-making on presentation of data i.e. if data are presented in a narrative, tabular or graphical format.

Figure 1. Example of ToxRTool.

A screenshot of the ToxRTool. The image shows a form with multiple sections and lines of text and highlighted sections in green. Text varies in colour black, red and blue.

A screenshot of the ToxRTool. The image shows a form with multiple sections and lines of text and highlighted sections in green. Text varies in colour black, red and blue.

Figure 2. Example of NOS

An example of NOS, shows a screenshot of a  black and white document with multiple headings and numbered sections.

An example of NOS, shows a screenshot of a black and white document with multiple headings and numbered sections.

Figure 3. Example of STROBE

Example of Strobe, is a screenshot of a black and white text document. The document has multiple sections with headings, item numbering and notes.

Example of Strobe, is a screenshot of a black and white text document. The document has multiple sections with headings, item numbering and notes.