Per- and polyfluoroalkyl substances: evaluation of thyroid effects using in vitro data - PFAS/2023/05

List of Abbreviations

PFAS/2023/05

Last updated: 24 September 2025

This is a paper for discussion. This does not represent the views of the Committee and should not be cited.

6:2 FTOH

6:2 Fluorotelomer alcohol

6:2 FTUA

2H-Perfluoro-2-octenoic acid (6:2)

7H PFHpA

7H-Perfluoroheptanoic acid

8:2 FTOH

8:2 Fluorotelomer alcohol

10:2 FTOH

10:2 Fluorotelomer alcohol

AhR

Aryl hydrocarbon receptor

AhR-REP

AhR-mediated relative potency

AhR-tact

AhR transactivity

C6O4

Perfluoro{acetic acid, 2-[(5-methoxy-1,3-dioxolan-4-yl)

oxy]}, ammonium salt

C6 PFPA

Pentafluoropropionic anhydride

cAMP

Cyclic adenosine monophosphate

CAS

Chemical abstract service

COT

Committee on Toxicity of Chemicals in Food, Consumer Products and the Environment

DMSO

Dimethyl sulfoxide

EFSA

European Food Safety Authority

EtOH

Ethyl alcohol

EU

European Union

F-53B

6:2 chlorinated polyfluorinated ether sulfonate

FOSA

Perfluorinated sulfonamide

FOSE

N-alkylperfluorooctane sulfonamidoethanols

FRTL

Fischer rat thyroid cell line

F-T4

Fluorescein-thyroxine

FTOH

Fluorotelomer alcohol

GL

Guideline

GLP

Good laboratory practice

HBGV

Health-based guidance value

HEK

Human Embryonic Kidney

IC50

Inhibitory concentration 50%

LDH

Lactate dehydrogenase

LOEC

Lowest observed effect concentration

L-PFDS

Perfluorodecane sulfonate

L-PFOSi

Perfluorooctane sulfinate

MC540

Merocyanine 540

MOEC

Maximum observed effect concentration

NA

Not applicable

ND

Not detected

N-EtFOSA

2-(N-ethylperfluoro-1-octane sulfonamido) ethanol

N-EtFOSE

2-(N-ethylperfluoro-1-octane sulfonamido) ethanol

NHT

Normal Human Thyroid

NIS

Sodium/iodide symporter

N-MeFOSA

N-methyl perfluorooctane sulfonamide

N-MeFOSE

2-(N-methylperfluoro-1-octane sulfonamido) ethanol

N,N-Me2FOSA

N,N-dimethyl perfluorooctane sulfonamide

PFAS

Per- and polyfluoroalkyl substances

PFBA

Perfluorobutanoate / Perfluorobutanoic acid

PFBS

Perfluorobutane sulfonate / Perfluorobutane sulfonic acid

PFCs

Poly- and perfluorinated compounds

PFCA

Perfluoroalkyl carboxylic acids

PFDA

Perfluorodecanoate / Perfluorodecanoic acid

PFDoA

Perfluorododecanoic acid

PFHpA

Perfluoroheptanoate / Perfluoroheptanoic acid

PFHxA

Perfluorohexanoate / Perfluorohexanoic acid

PFHxDA

Perfluorohexadecanoic acid

PFHxS

Perfluorohexane sulfonate

PFNA

Perfluorononanoate / Perfluorononanoic acid

PFOA

Perfluorooctanoate / Perfluorooctanoic acid

PFOS

Perfluorooctane sulfonate / Perfluorooctane sulfonic acid

PFOSA

Perfluorooctane sulfonamide

PFOSi

Perfluorooctane sulfinic acid

PFPA

Perfluoroalkyl phosphonic acids

PFPeA

Perfluoropentanoate / Perfluoropentanoic acid

PFSA

Perfluorosulfonic acids

PFSIA

Perfluoroalkane sulfinic acid

PFTrDA

Perfluorotridecanoate /Perfluorotridecanoic acid

PFTeDA

Perfluorotetradecanoate / Perfluorotetradecanoic acid

PFUnA

Perfluoroundecanoate / Perfluoroundecanoic acid

PPAR

Proliferator-activated receptor

RNA

Ribonucleic acid

ROS

Reactive oxygen species

RP

Relative potency

T3

Triiodothyronine

T4

Thyroxine

TBG

Thyroxine-binding globulin

TCDD

2,3,7,8 -Tetrachlorodibenzo-p-dioxin

TH

Thyroid hormone

TPO

Thyroperoxidase

TR

Thyroid hormone receptor

TSH

Thyroid stimulating hormone

TSH-R

Thyroid stimulating hormone receptor

TTR

Transthyretin (thyroid hormone transport protein)

US EPA

United States Environmental Protection Agency

WT

Wild type