Per- and polyfluoroalkyl substances: evaluation of thyroid effects using in vivo data (update) - PFAS/2023/04 PFAS/2023/04

List of Abbreviations - PFAS/2023/04

PFAS/2023/04

Last updated: 31 October 2024

125I

Iodine-125

ANCOVA

Analysis of covariance

ATSDR

Agency for Toxic Substances and Disease Registry

BMD

Benchmark dose

CAR

Constitutive androstane receptor

CAS

Chemical abstracts service

CF

Cross foster

COT

Committee on Toxicity

CT

Litters from treated dams fostered by control dams (pups only exposed postnatally)

DIO1

Type 1 deiodinase, iodothyronine deiodinase type 1

EFSA

European Food Safety Authority

FDA

Food and Drug Administration

EtoH

Ethyl alcohol

FT3

Free triiodothyronine

FT4

Free thyroxine

FTI

Free thyroxine index

GD

Gestational day

GL

Guideline

GLP

Good laboratory practice

HBGV

Health-based guidance value

HPT

Hypothalamic–pituitary–thyroid

i.p.

Intraperitoneal

LD

Lactation day

LOAEL

Lowest observed adverse effect level

LOEL

Lowest observed effect level

ME

Malic enzyme

mRNA

Messenger ribonucleic acid

MRP2

Multidrug resistance–associated protein

NA

Not applicable

NAM

New approach methodology

ND

Not detected

NIS

Sodium-iodide symporter

NOAEL

No observed adverse effect level

NR

Not reported

NTP

National Toxicology Program

OECD

Organisation for Economic Co-operation and Development

PFAS

Per- and polyfluoroalkyl substances

PFBA

Perfluorobutanoate / Perfluorobutanoic acid

PFBS

Perfluorobutane sulfonate / Perfluorobutane sulfonic acid

PFCA

Perfluoroalkyl carboxylic acid

PFDA

Perfluorodecanoate / Perfluorodecanoic acid

PFHpS

Perfluoroheptanesulfonate / Perfluoroheptane sulfonic acid

PFHxA

Perfluorohexanoate / Perfluorohexanoic acid

PFHxDA

Perfluorohexadecanoic acid

PFHxS

Perfluorohexanesulfonate / Perfluorohexanesulfonic acid

PFNA

Perfluorononanoate / Perfluorononanoic acid

PFOA

Perfluorooctanoate / Perfluorooctanoic acid

PFOS

Perfluorooctane sulfonate / Perfluorooctane sulfonic acid

PFPeS

Perfluoropentanesulfonate

PFPS

Perfluoropropanesulfonate

PFSA

Perfluorosulfonic acids 

PFTeDA

Perfluorotetradecanoate / Perfluorotetradecanoic acid

PND

Postnatal day

POD

Point of departure

PPARα

Peroxisome proliferator-activated receptor α

PXR

Pregnane X receptor

QA

Quality assurance

RNA

Ribonucleic acid

rT3

Reverse triiodothyronine

SD

Standard deviation

SE

Standard error

T3

Triiodothyronine

T4

Thyroxine

TC

Litters from treated dams fostered by control dams (pups only exposed prenatally

TT3

Total triiodothyronine

TT4

Total thyroxine

TH

Thyroid hormone

TG

Thyroglobulin

Trh

Thyrotropin releasing hormone

TSH

Thyrotropin also thyroid stimulating hormone

TSHR

Thyroid stimulating hormone receptor

TT

Litters from treated dams fostered by other treated dams (pups exposed prenatally and postnatally)

TTR

Transthyretin

UGT

Uridine diphospho-glucuronosyl transferase

USEPA

United States Environmental Protection Agency