Handbook - COT FSA PBPK for Regulators Workshop 2021
Handbook table of contents - 2021 Workshop
In this guide
In this guide
| About the Committee on Toxicity of Chemicals in Food, Consumer Products and the Environment (COT) | 3 |
| About the UK Food Standards Agency (FSA) | 4 |
| Notes on data and presentations at the workshop | 4 |
| Preface and workshop objectives |
6 |
| PBPK for Regulators Workshop agenda | 7 |
| Introduction to physiologically based pharmacokinetic (PBPK) modelling | 8 |
| PBPK modelling: Considerations of the COT | 14 |
| PBPK models | 14 |
| RVis | 14 |
| European Food Safety Authority (EFSA): A Web-based open source tool for toxicokinetic (TK) and toxicodynamic (TD) modelling | 14 |
| In emerging approaches | 16 |
| Cumulative Risk Assessment Approach for Mixtures | 16 |
| Current regulatory landscape | 17 |
| Questions put forward for the discussion sessions | 20 |
| Limitations / Ensuring fit for purpose | 20 |
| Potential applications | 21 |
Validation for regulatory application |
21 |
| Duties as regulators | 21 |
| Speakers biosketches | 22 |
| Professor Alan Boobis OBE | 22 |
| Dr Melvin Ernest Andersen PhD, CIH, DABT, ATS | 22 |
| Professor Mark Cronin | 23 |
| Professor Amin Rostami-Hodjegan PhD, FCP, FAAPS, FJSSX | 23 |
| Dr Alexander J. Stevens BSc, MSc, PhD | 24 |
| Dr Sheila Annie Peters | 25 |
| Dr George Loizou PhD | 26 |
| Dr Judith Madden | 26 |
| Dr Harvey J. Clewell III PhD, DABT, FATS | 27 |
| COT Members | 28 |
| COT Secretariat | 28 |
| Abbreviations | 29 |
| References | 30 |