References
In this guide
In this guideAhmadi, F., Kariman, K., Mousavi, M., Rengel, Z. (2024). Echinacea: Bioactive Compounds and Agronomy. Plants 13, 1235. Echinacea: Bioactive Compounds and Agronomy
Ardjomand-Woelkart, K., Bauer, R. (2015). Review and Assessment of Medicinal Safety Data of Orally Used Echinacea Preparations. Planta Med. 82, 17–31. Thieme E-Journals - Planta Medica / Abstract
Ardjomand-Woelkart, K., Kollroser, M., Derendorf, H., Bauer, R., Butterweck, V. (2012). Herb-Drug Interactions: Effects of Echinacea preparations on cytochrome P450 activities in rats. Planta Med. 78.
Barcz, E., Sommer, E., Nartowska, J., Balan, B.J., Chorostowska-Wynimko, J., Ewa, Skopińska-Różewska, E. (2007). Influence of Echinacea purpurea intake during pregnancy on fetal growth and tissue angiogenic activity. Folia Histochem Cytobiol. ;45 Suppl 1:S35-9.
Barnes, J., Anderson, L.A., Gibbons, S., Phillipson, J.D. (2010). Echinacea species (Echinacea angustifolia (DC.) Hell., Echinacea pallida (Nutt.) Nutt., Echinacea purpurea (L.) Moench): a review of their chemistry, pharmacology and clinical properties. J. Pharm. Pharmacol. 57, 929–954. Echinacea species (Echinacea angustifolia (DC.) Hell., Echinacea pallida (Nutt.) Nutt., Echinacea purpurea (L.) Moench): a review of their chemistry, pharmacology and clinical properties† | Journal of Pharmacy and Pharmacology | Oxford Academic
Binns, S.E., Hudson, J., Merali, S., Arnason, J.T. (2002). Antiviral Activity of Characterized Extracts from Echinacea spp. (Heliantheae: Asteraceae) against Herpes simplex Virus (HSV-I). Planta Med. 68, 780–783. Thieme E-Journals - Planta Medica / Abstract
Blumenthal, M., Busse, W.R., Bundesinstitut für Arzneimittel und Medizinprodukte (Eds.), (1999). The Complete German Commission E monographs: therapeutic guide to herbal medicines, Reprint. ed. American Botanical Council [u.a.], Austin, Texas.
Buettner, C., Mukamal, K.J., Gardiner, P., Davis, R.B., Phillips, R.S., Mittleman, M.A., (2009). Herbal Supplement Use and Blood Lead Levels of United States Adults. J. Gen. Intern. Med. 24, 1175–1182. Herbal Supplement Use and Blood Lead Levels of United States Adults | Journal of General Internal Medicine
Burger, R.A., Torres, A.R., Warren, R.P., Caldwell, V.D., Hughes, B.G. (1997). Echinacea-induced cytokine production by human macrophages. Int. J. Immunopharmacol. 19, 371–379. https://doi.org/10.1016/S0192-0561(97)00061-1
Burlou-Nagy, C., Bănică, F., Jurca, T., Vicaș, L.G., Marian, E., Muresan, M.E., Bácskay, I., Kiss, R., Fehér, P., Pallag, A. (2022). Echinacea purpurea (L.) Moench: Biological and Pharmacological Properties. A Review. Plants 11, 1244. https://doi.org/10.3390/plants11091244
Chow, G., Johns, T., Miller, S.C. (2006). Dietary Echinacea purpurea during Murine Pregnancy: Effect on Maternal Hemopoiesis and Fetal Growth. Neonatology 89, 133–138. https://doi.org/10.1159/000088795
Clifford, L.J., Nair, M.G., Rana, J., Dewitt, D.L. (2002). Bioactivity of alkylamides isolated from Echinacea purpurea (L.) Moench. Phytomedicine 9, 249–253. https://doi.org/10.1078/0944-7113-00105
Committee on herbal medicinal products (HMPC) (2007). Community list entry on Echinacea purpurea (L.) Moench, herba recens. Community list entry Echinaceae purpureae (L.) Moench, herba recens (europa.eu)
Currier, N., 2000. Natural killer cells from aging mice treated with extracts from Echinacea purpurea are quantitatively and functionally rejuvenated. Exp. Gerontol. 35, 627–639. https://doi.org/10.1016/S0531-5565(00)00106-6
Currier, N.L., Miller, S.C. (2002). The Effect of Immunization with Killed Tumor Cells, with/Without Feeding of Echinacea purpurea in an Erythroleukemic Mouse Model. J. Altern. Complement. Med. 8, 49–58. https://doi.org/10.1089/107555302753507177
Cuzzolin, L., Francini‐Pesenti, F., Verlato, G., Joppi, M., Baldelli, P., Benoni, G. (2010). Use of herbal products among 392 Italian pregnant women: focus on pregnancy outcome. Pharmacoepidemiol. Drug Saf. 19, 1151–1158. https://doi.org/10.1002/pds.2040
Dabbou, S., Rotolo, L., Kovitvadhi, A., Bergagna, S., Dezzutto, D., Barbero, R., Rubiolo, P., Schiavone, A., De Marco, M., Helal, A.N., Zoccarato, I., Gasco, L. (2016). Rabbit dietary supplementation with pale purple coneflower. 1. Effects on the reproductive performance and immune parameters of does. Animal 10, 1101–1109. https://doi.org/10.1017/S1751731115002979
Dapas, B., Dall’Acqua, S., Bulla, R., Agostinis, C., Perissutti, B., Invernizzi, S., Grassi, G., Voinovich, D. (2014). Immunomodulation mediated by a herbal syrup containing a standardized Echinacea root extract: A pilot study in healthy human subjects on cytokine gene expression. Phytomedicine 21, 1406–1410. https://doi.org/10.1016/j.phymed.2014.04.034
De Fougerolles, A.R., Baines, M.G. (1987). Modulation of the natural killer cell activity in pregnant mice alters the spontaneous abortion rate. J. Reprod. Immunol. 11, 147–153. https://doi.org/10.1016/0165-0378(87)90018-0
Di Lorenzo, C., Ceschi, A., Kupferschmidt, H., Lüde, S., De Souza Nascimento, E., Dos Santos, A., Colombo, F., Frigerio, G., Nørby, K., Plumb, J., Finglas, P., Restani, P. (2015). Adverse effects of plant food supplements and botanical preparations: a systematic review with critical evaluation of causality. Br. J. Clin. Pharmacol. 79, 578–592. https://doi.org/10.1111/bcp.12519
EMA (2012): Assessment report on Echinacea angustifolia DC., radix. EMA/HMPC/688212/2008. Assessment report on Echinacea angustifolia DC., radix (europa.eu)
EMA (2014): Assessment report on Echinacea purpurea (L.) Moench., herba recens. EMA/HMPC/557979/2013. Assessment report on Echinacea purpurea (L.) Moench., herba recens (europa.eu)
EMA (2018): Assessment report on Echinacea pallida (Nutt.) Nutt., radix. EMA/HMPC/737379/2017. Assessment report on Echinacea pallida (Nutt.) Nutt., radix (europa.eu)
EMA monograph (2012): Community herbal monograph on Echinacea angustifolia DC., radix. EMA/HMPC/688216/2008. Community herbal monograph on Echinacea angustifolia DC., radix (europa.eu)
EMA monograph (2014): European Union herbal monograph on Echinacea purpurea (L.) Moench, herba recens. (EMEA/HMPC/104945/2006. European Union herbal monograph on Echinacea purpurea (L.) Moench, herba recens (europa.eu)
EMA monograph (2017): European Union herbal monograph on Echinacea purpurea (L.) Moench, radix. EMA/HMPC/577784/2008. European Union herbal monograph on Echinacea purpurea (L.) Moench, radix (europa.eu)
EMA monograph (2018): European Union herbal monograph on Echinacea pallida (Nutt.) Nutt., radix. (EMEA/HMPC/332350/2008. European Union herbal monograph on Echinacea pallida (Nutt.) Nutt., radix (europa.eu)
Espinosa-Paredes, D.A., Cornejo-Garrido, J., Moreno-Eutimio, M.A., Martínez-Rodríguez, O.P., Jaramillo-Flores, M.E., Ordaz-Pichardo, C. (2021). Echinacea Angustifolia DC Extract Induces Apoptosis and Cell Cycle Arrest and Synergizes with Paclitaxel in the MDA-MB-231 and MCF-7 Human Breast Cancer Cell Lines. Nutr. Cancer 73, 2287–2305. https://doi.org/10.1080/01635581.2020.1817956
Filipiak-Szok, A., Kurzawa, M., Szłyk, E. (2015). Determination of toxic metals by ICP-MS in Asiatic and European medicinal plants and dietary supplements. J. Trace Elem. Med. Biol. 30, 54–58. https://doi.org/10.1016/j.jtemb.2014.10.008
Fonseca, F.N., Papanicolaou, G., Lin, H., Lau, C.B.S., Kennelly, E.J., Cassileth, B.R., Cunningham-Rundles, S. (2014). Echinacea purpurea (L.) Moench modulates human T-cell cytokine response. Int. Immunopharmacol. 19, 94–102. https://doi.org/10.1016/j.intimp.2013.12.019
Fusco, D., Liu, X., Savage, C., Taur, Y., Xiao, W., Kennelly, E., Yuan, J., Cassileth, B., Salvatore, M., Papanicolaou, G.A. (2010). Echinacea purpurea aerial extract alters course of influenza infection in mice. Vaccine 28, 3956–3962. https://doi.org/10.1016/j.vaccine.2010.03.047
Gallo, M., Sarkar, M., Au, W., Pietrzak, K., Comas, B., Smith, M., Jaeger, T.V., Einarson, A., Koren, G. (2000). Pregnancy Outcome Following Gestational Exposure to Echinacea: A Prospective Controlled Study. Arch. Intern. Med. 160, 3141.: Pregnancy Outcome Following Gestational Exposure to Echinacea: A Prospective Controlled Study | Complementary and Alternative Medicine | JAMA Internal Medicine | JAMA Network
Gan, X.-H., Zhang, L., Heber, D., Bonavida, B. (2003). Mechanism of activation of human peripheral blood NK cells at the single cell level by Echinacea water soluble extracts: recruitment of lymphocyte–target conjugates and killer cells and activation of programming for lysis. Int. Immunopharmacol. 3, 811–824. https://doi.org/10.1016/S1567-5769(02)00298-9
Gendron, R.L., Baines, M.G. (1988). Infiltrating decidual natural killer cells are associated with spontaneous abortion in mice. Cell. Immunol. 113, 261–267. https://doi.org/10.1016/0008-8749(88)90025-1
George, L., Ioannis, E., Radostina, T., Antonios, M. (2006). Severe thrombotic thrombocytopenic purpura (TTP) induced or exacerbated by the immunostimulatory herb Echinacea. Am. J. Hematol. 81, 224–224. https://doi.org/10.1002/ajh.20531
Goel, V., Chang, C., Slama, J.V., Barton, R., Bauer, R., Gahler, R., Basu, T.K. (2002). Echinacea stimulates macrophage function in the lung and spleen of normal rats. J. Nutr. Biochem. 13, 487–492. https://doi.org/10.1016/S0955-2863(02)00190-0
Gorski, J. (2004). The effect of echinacea (Echinacea purpurea root) on cytochrome P450 activity in vivo. Clin. Pharmacol. Ther. 75, 89–100. https://doi.org/10.1016/j.clpt.2003.09.013
Gurley, B., Gardner, S., Hubbard, M., Williams, D., Gentry, W., Carrier, J., Khan, I., Edwards, D., Shah, A. (2004). In vivo assessment of botanical supplementation on human cytochrome P450 phenotypes: Citrus aurantium, Echinacea purpurea, milk thistle, and saw palmetto. Clin. Pharmacol. Ther. 76, 428–440. https://doi.org/10.1016/j.clpt.2004.07.007
Gurley, B.J., Swain, A., Hubbard, M.A., Williams, D.K., Barone, G., Hartsfield, F., Tong, Y., Carrier, D.J., Cheboyina, S., Battu, S.K. (2008). Clinical assessment of CYP2D6‐mediated herb–drug interactions in humans: Effects of milk thistle, black cohosh, goldenseal, kava kava, St. John’s wort, and Echinacea. Mol. Nutr. Food Res. 52, 755–763. https://doi.org/10.1002/mnfr.200600300
Hall, H.G., Griffiths, D.L., McKenna, L.G. (2011). The use of complementary and alternative medicine by pregnant women: A literature review. Midwifery 27, 817–824. https://doi.org/10.1016/j.midw.2010.08.007
Hansen, T.S., Nilsen, O.G. (2009). Echinacea purpurea and P‐glycoprotein drug transport in Caco‐2 cells. Phytother. Res. 23, 86–91. https://doi.org/10.1002/ptr.2563
Heitmann, K., Havnen, G.C., Holst, L., Nordeng, H. (2016). Pregnancy outcomes after prenatal exposure to Echinacea: the Norwegian Mother and Child Cohort Study. Eur. J. Clin. Pharmacol. 72, 623–630. Pregnancy outcomes after prenatal exposure to echinacea: the Norwegian Mother and Child Cohort Study | European Journal of Clinical Pharmacology
Hellum, B.H., Hu, Z., Nilsen, O.G. (2007). The Induction of CYP1A2, CYP2D6 and CYP3A4 by Six Trade Herbal Products in Cultured Primary Human Hepatocytes. Basic Clin. Pharmacol. Toxicol. 100, 23–30. https://doi.org/10.1111/j.1742-7843.2007.00011.x
Hellum, B.H., Nilsen, O.G. (2007). The in vitro Inhibitory Potential of Trade Herbal Products on Human CYP2D6‐Mediated Metabolism and the Influence of Ethanol. Basic Clin. Pharmacol. Toxicol. 101, 350–358. https://doi.org/10.1111/j.1742-7843.2007.00121.x
HMR 2012: The Human Medicines Regulations 2012. Available at: The Human Medicines Regulations 2012 (legislation.gov.uk)
Holst, L., Wright, D., Haavik, S., Nordeng, H. (2011). Safety and efficacy of herbal remedies in obstetrics—review and clinical implications. Midwifery 27, 80–86. https://doi.org/10.1016/j.midw.2009.05.010
Hudson, J., Vimalanathan, S., Kang, L., Amiguet, V.T., Livesey, J., Arnason, J.T. (2005). Characterization of Antiviral Activities in Echinacea Root Preparations. Pharm. Biol. 43, 790–796. https://doi.org/10.1080/13880200500408491
Hudson, J.B. (2012). Applications of the Phytomedicine Echinacea purpurea (Purple Coneflower) in Infectious Diseases. J. Biomed. Biotechnol. 1–16. https://doi.org/10.1155/2012/769896
Huntley, A.L., Thompson Coon, J., Ernst, E. (2005). The Safety of Herbal Medicinal Products Derived from Echinacea Species: A Systematic Review. Drug Saf. 28, 387–400. The Safety of Herbal Medicinal Products Derived from Echinacea Species | Drug Safety
Husain, I., Dale, O.R., Martin, K., Gurley, B.J., Adams, S.J., Avula, B., Chittiboyina, A.G., Khan, I.A., Khan, S.I. (2023). Screening of medicinal plants for possible herb-drug interactions through modulating nuclear receptors, drug-metabolizing enzymes and transporters. J. Ethnopharmacol. 301, 115822. https://doi.org/10.1016/j.jep.2022.115822
Jacobsson, I., Jönsson, A.K., Gerdén, B., Hägg, S. (2009). Spontaneously reported adverse reactions in association with complementary and alternative medicine substances in Sweden. Pharmacoepidemiol. Drug Saf. 18, 1039–1047. https://doi.org/10.1002/pds.1818
Jawad, M., Schoop, R., Suter, A., Klein, P., Eccles, R. (2012). Safety and Efficacy Profile of Echinacea purpurea to Prevent Common Cold Episodes: A Randomized, Double-Blind, Placebo-Controlled Trial. Evid. Based Complement. Alternat. Med. 2012, 1–7. https://doi.org/10.1155/2012/841315
Jeong, J.-S., Kim, J.-W., Kim, J.-H., Chung, E.-H., Lee, D.-R., Choi, B.-K., Ko, J.-W., Kim, T.-W. (2024). Oral toxicity and genotoxicity assessment of standardized Echinacea purpurea (L.) extract and the pharmacokinetic profile of its active ingredient chicoric acid. Toxicol. Res. 40, 457–472. Oral toxicity and genotoxicity assessment of standardized Echinacea purpurea (L.) extract and the pharmacokinetic profile of its active ingredient chicoric acid | Toxicological Research
Kemp, D.E., Franco, K.N. (2002). Possible leukopenia associated with long-term use of Echinacea. J. Am. Board Fam. Pract. 15, 417.
Khaksary Mahabady, M., Ranjbar, R., Arzi, A., Papahn, A.A., Najafzadeh, H. (2006). A comparison study of effects of Echinacea extract and levamisole on phenytoin-induced cleft palate in mice. Regul. Toxicol. Pharmacol. 46, 163–166. https://doi.org/10.1016/j.yrtph.2006.06.005
Kocaman, O., Hulagu, S., Senturk, O. (2008). Echinacea-induced severe acute hepatitis with features of cholestatic autoimmune hepatitis. Eur. J. Intern. Med. 19, 148. Echinacea-induced severe acute hepatitis with features of cholestatic autoimmune hepatitis - European Journal of Internal Medicine
Kovitvadhi, A., Gai, F., Dabbou, S., Ferrocino, I., Rotolo, L., Falzone, M., Vignolini, C., Gennero, M.S., Bergagna, S., Dezzutto, D., Barbero, R., Nebbia, P., Rosati, S., Cocolin, L., Zoccarato, I., Gasco, L. (2016). Rabbit dietary supplementation with pale purple coneflower. 2. Effects on the performances, bacterial community, blood parameters and immunity of growing rabbits. Animal 10, 1110–1117. https://doi.org/10.1017/S1751731115002980
Lee, A.N., Werth, V.P. (2004). Activation of Autoimmunity Following Use of Immunostimulatory Herbal Supplements. Arch. Dermatol. 140. Activation of Autoimmunity Following Use of Immunostimulatory Herbal Supplements | Complementary and Alternative Medicine | JAMA Dermatology | JAMA Network
Lee Soon, S., Crawford, R.I. (2001). Recurrent erythema nodosum associated with Echinacea herbal therapy. J. Am. Acad. Dermatol. 44, 298–299. Recurrent erythema nodosum associated with echinacea herbal therapy - Journal of the American Academy of Dermatology
Lenk, W. (1989). Akute toxizitat von verschiedenen polysacchariden Echinacea purpurea an der maus.[Acute toxicity of various polysaccharides from Echinacea purpurea in the mouse.]. Zeitschrift fur Phytotherapie, 10, pp.49-51.
Li, Y., Wang, Y., Wu, Y., Wang, B., Chen, X., Xu, Xin, Chen, H., Li, W., Xu, Xiaogang, (2017). Echinacea pupurea extracts promote murine dendritic cell maturation by activation of JNK, p38 MAPK and NF-κB pathways. Dev. Comp. Immunol. 73, 21–26. https://doi.org/10.1016/j.dci.2017.03.002
Maass, N., Bauer, J., Paulicks, B.R., Böhmer, B.M., Roth‐Maier, D.A. (2005). Efficiency of Echinacea purpurea on performance and immune status in pigs. J. Anim. Physiol. Anim. Nutr. 89, 244–252. https://doi.org/10.1111/j.1439-0396.2005.00501.x
Mahajan, D., Sharma, N. R., Kancharla, S., Kolli, P., Tripathy, A., Sharma, A. K., Singh, S., Kumar, S., Mohanty, A. K., & Jena, M. K. (2022). Role of Natural Killer Cells during Pregnancy and Related Complications. Biomolecules, 12(1), 68. https://doi.org/10.3390/biom12010068
Maskatia, Z.K., Baker, K. (2010). Hypereosinophilia Associated with Echinacea Use: South. Med. J. 103, 1173–1174. https://doi.org/10.1097/smj.0b013e3181f1ed8b
Matthias, A., Merika, H., Addison, R., Bone, K., Lehmann, R. (2008). Bioavailability of Echinacea alkylamides in human breast milk. Planta Med. 74, s-0028-1083939. https://doi.org/10.1055/s-0028-1083939
Melchart D, Linde K, Worku F, Sarkady L, Holzmann M, Jurcic K, Wagner H (1995). Results of five randomized studies on the immunomodulatory activity of preparations of Echinacea. J Altern Complement Med. Summer;1(2):145-60. doi: 10.1089/acm.1995.1.145. PMID: 9395611. PMID: 9395611.
Melchart, D. (1998). Echinacea Root Extracts for the Prevention of Upper Respiratory Tract Infections: A Double-blind, Placebo-Controlled Randomized Trial. Arch. Fam. Med. 7, 541–545. https://doi.org/10.1001/archfami.7.6.541
Mengs, U., Clare, C.B., Poiley, J.A. (1991). Toxicity of Echinacea purpurea. Acute, subacute and genotoxicity studies. Arzneimittelforschung. 41, 1076–1081.
Merali, S., Binns, S., Paulin-Levasseur, M., Ficker, C., Smith, M., Baum, B., Brovelli, E., Arnason, J.T. (2003). Antifungal and Anti-inflammatory Activity of the Genus Echinacea. Pharm. Biol. 41, 412–420. https://doi.org/10.1076/phbi.41.6.412.17828
Modarai, M., Gertsch, J., Suter, A., Heinrich, M., Kortenkamp, A. (2010). Cytochrome P450 inhibitory action of Echinacea preparations differs widely and co-varies with alkylamide content. J. Pharm. Pharmacol. 59, 567–573. https://doi.org/10.1211/jpp.59.4.0012
Mrozikiewicz, P.M., Bogacz, A., Karasiewicz, M., Mikolajczak, P.L., Ozarowski, M., Seremak-Mrozikiewicz, A., Czerny, B., Bobkiewicz-Kozlowska, T., Grzeskowiak, E.(2010). The effect of standardized Echinacea purpurea extract on rat cytochrome P450 expression level. Phytomedicine 17, 830–833. https://doi.org/10.1016/j.phymed.2010.02.007
Mullins, R.J. (1998). Echinacea‐associated anaphylaxis. Med. J. Aust. 168, 170–171. https://doi.org/10.5694/j.1326-5377.1998.tb126773.x
Mullins, R.J., Heddle, R. (2002). Adverse reactions associated with Echinacea: the Australian experience. Ann. Allergy. Asthma. Immunol. 88, 42–51. https://doi.org/10.1016/S1081-1206(10)63591-0
Nordeng, H., Bayne, K., Havnen, G.C., Paulsen, B.S. (2011). Use of herbal drugs during pregnancy among 600 Norwegian women in relation to concurrent use of conventional drugs and pregnancy outcome. Complement. Ther. Clin. Pract. 17, 147–151. https://doi.org/10.1016/j.ctcp.2010.09.002
Ondrizek, R.R., Chan, P.J., Patton, W.C., King, A. (1999). Inhibition of Human Sperm Motility by Specific Herbs Used in Alternative Medicine. J. Assist. Reprod. Genet. 16, 87–91. https://doi.org/10.1023/A:1022568823262
Penzak, S.R., Robertson, S.M., Hunt, J.D., Chairez, C., Malati, C.Y., Alfaro, R.M., Stevenson, J.M., Kovacs, J.A. (2010). Echinacea purpurea Significantly Induces Cytochrome P450 3A Activity but Does Not Alter Lopinavir‐Ritonavir Exposure in Healthy Subjects. Pharmacother. J. Hum. Pharmacol. Drug Ther. 30, 797–805. https://doi.org/10.1592/phco.30.8.797
Perri D, Dugoua JJ, Mills E, Koren G. (2006): Safety and efficacy of Echinacea (Echinacea angustafolia, E. purpurea and E. pallida) during pregnancy and lactation. Can J Clin Pharmacol, 13(3): e262-267.
Pilarska, G., Twarużek, M., Ałtyn, I. (2022). The Presence of Molds and Their Secondary Metabolites in Purple Coneflower-Based Dietary Supplements (Echinacea purpurea (L.) Moench). Toxins 14, 607. https://doi.org/10.3390/toxins14090607
Pleschka, S., Stein, M., Schoop, R., Hudson, J.B. (2009). Anti-viral properties and mode of action of standardized Echinacea purpurea extract against highly pathogenic avian Influenza virus (H5N1, H7N7) and swine-origin H1N1 (S-OIV). Virol. J. 6, 197. https://doi.org/10.1186/1743-422X-6-197
Raman, P., Patino, L.C., Nair, M.G. (2004). Evaluation of Metal and Microbial Contamination in Botanical Supplements. J. Agric. Food Chem. 52, 7822–7827. https://doi.org/10.1021/jf049150
Raner, G.M., Cornelious, S., Moulick, K., Wang, Y., Mortenson, A., Cech, N.B. (2007). Effects of herbal products and their constituents on human cytochrome P4502E1 activity. Food Chem. Toxicol. 45, 2359–2365. https://doi.org/10.1016/j.fct.2007.06.012
Rininger, J.A., Kickner, S., Chigurupati, P., McLean, A., Franck, Z. (2002). Immunopharmacological activity of Echinacea preparations following simulated digestion on murine macrophages and human peripheral blood mononuclear cells. J. Leukoc. Biol. 68, 503–510. https://doi.org/10.1189/jlb.68.4.503
Rondanelli, M., Miccono, A., Lamburghini, S., Avanzato, I., Riva, A., Allegrini, P., Faliva, M.A., Peroni, G., Nichetti, M., Perna, S. (2018). Self-Care for Common Colds: The Pivotal Role of Vitamin D, Vitamin C, Zinc, and Echinacea in Three Main Immune Interactive Clusters (Physical Barriers, Innate and Adaptive Immunity) Involved during an Episode of Common Colds—Practical Advice on Dosages and on the Time to Take These Nutrients/Botanicals in order to Prevent or Treat Common Colds. Evid. Based Complement. Alternat. Med. 2018, 1–36. https://doi.org/10.1155/2018/5813095
Schapowal, A., Klein, P., Johnston, S.L. (2015). Echinacea Reduces the Risk of Recurrent Respiratory Tract Infections and Complications: A Meta-Analysis of Randomized Controlled Trials. Adv. Ther. 32, 187–200. https://doi.org/10.1007/s12325-015-0194-4
See, D.M., Broumand, N., Sahl, L., Tilles, J.G. (1997). In vitro effects of Echinacea and ginseng on natural killer and antibody-dependent cell cytotoxicity in healthy subjects and chronic fatigue syndrome or acquired immunodeficiency syndrome patients. Immunopharmacology 35, 229–235. https://doi.org/10.1016/S0162-3109(96)00125-7
Sharma, M., Anderson, S.A., Schoop, R., Hudson, J.B. (2009). Induction of multiple pro-inflammatory cytokines by respiratory viruses and reversal by standardized Echinacea, a potent antiviral herbal extract. Antiviral Res. 83, 165–170. https://doi.org/10.1016/j.antiviral.2009.04.009
Signer, J., Jonsdottir, H.R., Albrich, W.C., Strasser, M., Züst, R., Ryter, S., Ackermann-Gäumann, R., Lenz, N., Siegrist, D., Suter, A., Schoop, R., Engler, O.B. (2020). In vitro virucidal activity of Echinaforce®, an Echinacea purpurea preparation, against coronaviruses, including common cold coronavirus 229E and SARS-CoV-2. Virol. J. 17, 136. https://doi.org/10.1186/s12985-020-01401-2
Svedlund, E., Larsson, M., Hägerkvist, R. (2017). Spontaneously Reported Adverse Reactions for Herbal Medicinal Products and Natural Remedies in Sweden 2007–15: Report from the Medical Products Agency. Drugs - Real World Outcomes 4, 119–125. https://doi.org/10.1007/s40801-017-0104-y
Tournas, V.H. (2009). Microbial contamination of select diatary supplements. J. Food Saf. 29, 430–442. https://doi.org/10.1111/j.1745-4565.2009.00167.x
Tsai, Y.-L., Chiou, S.-Y., Chan, K.-C., Sung, J.-M., Lin, S.-D. (2012a). Caffeic acid derivatives, total phenols, antioxidant and antimutagenic activities of Echinacea purpurea flower extracts. LWT - Food Sci. Technol. 46, 169–176. https://doi.org/10.1016/j.lwt.2011.09.026
Tsai, Y.-L., Chiu, C.-C., Yi-Fu Chen, J., Chan, K.-C., Lin, S.-D. (2012b). Cytotoxic effects of Echinacea purpurea flower extracts and chicoric acid on human colon cancer cells through induction of apoptosis. J. Ethnopharmacol. 143, 914–919. https://doi.org/10.1016/j.jep.2012.08.032
Upton, R. (Ed.) (2007). Echinacea purpurea aerial parts: Echinacea purpurea (L.) Moench ; standards of analysis, quality control, and therapeutics, American herbal pharmacopoeia and therapeutic compendium. American Herbal Pharmacopoeia, Scotts Valley, CA.
Vimalanathan, S., Kang, L., Amiguet, V.T., Livesey, J., Arnason, J.T., Hudson, J. (2005). Echinacea purpurea. Aerial Parts Contain Multiple Antiviral Compounds. Pharm. Biol. 43, 740–745. https://doi.org/10.1080/13880200500406354
Vonau, B., Chard, S., Mandalia, S., Wilkinson, D., Barton, S.E. (2001). Does the extract of the plant Echinacea purpurea influence the clinical course of recurrent genital herpes? Int. J. STD AIDS 12, 154–158. https://doi.org/10.1258/0956462011916947
Yale, S.H., Glurich, I. (2005). Analysis of the Inhibitory Potential of Ginkgo biloba, Echinacea purpurea, and Serenoa repens on the Metabolic Activity of Cytochrome P450 3A4, 2D6, and 2C9. J. Altern. Complement. Med. 11, 433–439. https://doi.org/10.1089/acm.2005.11.433
WHO (1999). Radix echinaceae. In: WHO monographs on selected medicinal plants, Vol. 1, WHO Geneva 1999, Switzerland: 128-135. WHO monographs on selected medicinal plants
Zhai, Z., Liu, Y., Wu, L., Senchina, D.S., Wurtele, E.S., Murphy, P.A., Kohut, M.L., Cunnick, J.E. (2007). Enhancement of Innate and Adaptive Immune Functions by Multiple Echinacea Species. J. Med. Food 10, 423–434. https://doi.org/10.1089/jmf.2006.257