Questions on which the views of the Committee are sought 

This is a paper for discussion. This does not represent the views of the Committee and should not be cited.

192.         Members are invited to consider the following questions: 

i). Are there any specific papers that the subgroup would like to review in more detail? 

ii). Recovery is assessed in a minority of studies. Should the N/LOAEL be based on effects seen at the end of treatment or after the recovery period? 

iii). Liver effects seen in developmental studies are presented for dams and offspring. The N/LOAELs are based on effects in the dam only. Does the subgroup agree with excluding effects seen in offspring, which will be reported in subsequent papers? 

IEH Consulting under contract supporting the UKHSA COT Secretariat 

December 2023