Per- and polyfluoroalkyl substances: evaluation of liver effects using in vivo data - PFAS/2023/06

List of Abbreviations

PFAS/2023/06

Last updated: 03 October 2025

This is a paper for discussion. This does not represent the views of the Committee and should not be cited.

ACO 

Acyl-CoA oxidase 

Acox1 

Acyl-CoA oxidase 1  

ALP 

Alkaline phosphatase 

ALT 

Alanine aminotransferase 

AKR1C1 

Aldo-Keto Reductase 1C1 

Apo 

Apolipoprotein  

APOA 

Apolipoprotein A 

AST 

Aspartate aminotransferase 

CAR 

Constitutive androstane receptor 

CAS 

Chemical abstracts service  

CAT 

Catalase  

Cd36 

Cluster of differentiation molecule 36 

CHE 

Cholinesterase 

COT 

Committee on Toxicity 

Cpt-1A 

Carnitine palmitoyltransferase 1A 

Cyp 

Cytochrome P450 

DIO1 

Type 1 deiodinase, iodothyronine deiodinase type 1 

EFSA 

European Food Safety Authority 

FA 

Fatty acid 

FDA 

Food and Drug Administration  

Fasn 

Fatty acid synthase 

G6PC 

Glucose 6-phosphatase enzyme 

GD 

Gestational day 

GL 

Guideline 

GLP 

Good laboratory practice 

HBGV 

Health-based guidance value 

HDL 

High density lipoprotein 

IL-1β 

Interleukin-1β 

i.p. 

Intraperitoneal  

LOAEL 

Lowest observed adverse effect level 

mRNA 

Messenger ribonucleic acid  

Myd88 

Myeloid differentiation primary response 88 

NA 

Not applicable 

NAM 

New approach methodology 

ND 

Not detected 

NOAEL 

No observed adverse effect level 

NR 

Not reported 

NTP 

National Toxicology Program 

OECD 

Organisation for Economic Co-operation and Development 

PCNA 

Proliferating cell nuclear antigen 

PEPCK 

Phosphoenolpyruvate carboxykinase 

PFAS 

Per- and polyfluoroalkyl substances 

PFBA 

Perfluorobutanoate / Perfluorobutanoic acid 

PFCA 

Perfluoroalkyl carboxylic acid 

PFDA 

Perfluorodecanoate / Perfluorodecanoic acid 

PFDoDA 

Perfluorododecanoic acid 

PFHxA 

Perfluorohexanoate / Perfluorohexanoic acid  

PFHxDA 

Perfluorohexadecanoic acid 

PFNA 

Perfluorononanoate / Perfluorononanoic acid 

PFOA 

Perfluorooctanoate / Perfluorooctanoic acid 

PFODA 

Perfluorooctadecanoic acid 

PFTeDA 

Perfluorotetradecanoate / Perfluorotetradecanoic acid 

PFUnDA 

Perfluoroundecanoic acid 

PND 

Postnatal day  

POD 

Point of departure 

Por 

Cytochrome P450 oxidoreductase 

PPARα 

Peroxisome proliferator-activated receptor-α 

PXR 

Pregnane X receptor 

QA 

Quality assurance 

SD 

Standard deviation 

SDH 

Sorbitol dehydrogenase 

Srebf1/2 

Sterol regulatory element-binding transcription factor 1/2 

TG 

Triglycerides  

TGF-β 

transforming growth factor-β 

TBA 

Thiobarbituricacid 

TLR-4 

Toll-like receptor-4 

TP 

Total protein 

TNF-α 

Tumour necrosis factor 

Traf6 

TNF receptor associated factor 6 

UGT 

Uridine diphospho-glucuronosyl transferase 

VLDL 

Very low-density lipoprotein