Herb-drug interactions
In this guide
In this guide
Author |
Test System |
Study size |
Exposure |
Characterisation of test substance |
Duration |
Main outcome measure |
Outcome |
Al-Omari et al., 2012 |
Albino rat, M |
30: 5 groups of 6; 72: 12 groups of 6. |
25, 50 and 100 mg/kg bw by gavage; single dose (50 mg/kg bw) and up to one week. |
Ginger crude extract. |
Multiple dose: 2 weeks; single dose: 1 week. |
Effect on glibenclamide and insulin; hypoglycaemic and antihyperglycemic effects in normoglycemic- and streptozotocin-induced (STZ) diabetic rats. |
Significant decrease in blood glucose level (BGL) in normoglycemic rats after 1 & 2 hrs (50 mg/kg). Significant decrease in non-fasting BGL (N-FBGL) in STZ- diabetic rats. |
Egashira et al., 2012 |
Sprague-Dawley rat, M (7 weeks old) |
Not specified. |
10 mL/kg orally. |
50% ginger juice. |
1-3 days. |
interaction between ginger juice and tacrolimus. |
Significant increase in tacrolimus blood concentrations in rats treated with ginger juice, compared to those treated with water or orange juice. |
Okonta et al., 2008 |
Rabbits (3F, 2M) |
5 |
1 ml/kg, orally. |
Ginger extract. |
3 days. |
Effect of ginger on the pharmacokinetics of metronidazole. |
Significant increase in absorption and plasma half-life; significant decrease in the elimination rate constant and clearance of metronidazole. |