Effect on Platelet Aggregation
In this guide
In this guide
Author |
Test System |
Study size |
Exposure |
Characterisation of test substance |
Main outcome measure |
Outcome |
Srivas, 1984 |
Human platelets and rat aorta. |
NA |
15-20 ul (concentrations not given). |
Ginger extracts in water, n-hexane, chloroform, and ethyl acetate. |
Effect of ginger extracts on in vitro platelet aggregation. |
Inhibition of arachidonic acid (AA), epinephrine, adenosine diphosphate (ADP), and collagen-induced platelet aggregation. |
Srivastava, 1986 |
Platelet rich plasma (no further information given). |
NA |
10-20 ul (concentrations not given). |
NA |
Effect of ginger and components on platelet aggregation and eicosanoid biosynthesis. |
Reduced thromboxane formation from exogenous AA; Inhibition of AA, epinephrine, ADP and collagen-induced platelet aggregation. |
Suekawa et al., 1986 (abstract only) |
Rat hind paw and aorta, rabbits. |
Unknown. |
Unknown. |
6-shogaol. |
Effect of 6-shogaol on arachidonic acid cascade. |
Inhibition of carrageenin-induced swelling of hind paw in rats and arachidonic acid (AA)-induced platelet aggregation in rabbits. Inhibition of prostaglandin 12 (PGI2) release in rat aorta. Possibly caused by COX inhibition. |
Thomson et al., 2002 |
Sprague-Dawley rats, Adult, F; ex vivo. |
36 |
50 mg/kg or 500 mg/kg daily by gavage or intraperitoneally (IP) for 4 weeks. |
Aqueous ginger extract, equivalent of 500 mg/ml. |
ex vivo effect |
Serum PGE2 reduced and both dose levels; high dose significantly reduced serum TXB2 both orally and IP; A non-significant reduction in the level of |
NA |
NA |
NA |
NA |
NA |
NA |
significant reduction in levels of |