Effect on Platelet Aggregation

Author

Test System

Study size

Exposure

Characterisation of test substance

Main outcome measure

Outcome

Srivas, 1984

Human platelets and rat aorta.

NA

15-20 ul (concentrations not given).

Ginger extracts in water, n-hexane, chloroform, and ethyl acetate.

Effect of ginger extracts on in vitro platelet aggregation.

Inhibition of arachidonic acid (AA), epinephrine, adenosine diphosphate (ADP), and collagen-induced platelet aggregation.

Srivastava, 1986

Platelet rich plasma (no further information given).

NA

10-20 ul (concentrations not given).

 NA

Effect of ginger and components on platelet aggregation and eicosanoid biosynthesis.

Reduced thromboxane formation from exogenous AA; Inhibition of AA, epinephrine, ADP and collagen-induced platelet aggregation.

Suekawa et al., 1986 (abstract only)

Rat hind paw and aorta, rabbits.

Unknown.

Unknown.

6-shogaol.

Effect of 6-shogaol on arachidonic acid cascade.

Inhibition of carrageenin-induced swelling of hind paw in rats and arachidonic acid (AA)-induced platelet aggregation in rabbits. Inhibition of prostaglandin 12 (PGI2) release in rat aorta. Possibly caused by COX inhibition.

Thomson et al., 2002

Sprague-Dawley rats, Adult, F; ex vivo.

36

50 mg/kg or 500 mg/kg daily by gavage or intraperitoneally (IP) for 4 weeks.

Aqueous ginger extract, equivalent of 500 mg/ml.

ex vivo effect
 of aqueous extract of ginger on the synthesis of
 thromboxane-B2, prostaglandin-E2, and cholesterol, 
 triglyceride levels in the serum of normal rats.

Serum PGE2 reduced and both dose levels; high dose significantly reduced serum TXB2 both orally and IP; A non-significant reduction in the level of 
 TXB2 observed when ginger was injected IP but not significantly different from saline group.

 NA

NA

NA

NA

NA

  NA

significant reduction in levels of
 cholesterol in rats given high dose; No significant change in triglyceride levels with either dose either orally or IP.