Summary of the EFSA Scientific Opinion on the Guidance on the use of Read-across for Chemical Safety Assessment in Food and Feed

Abbreviations

TOX/2025/42

Last updated: 08 October 2025

This is a paper for discussion. It does not reflect the views of the Committee and should not be cited.

(Q)SAR

(Quantitative) Structure–Activity Relationship

ADME

Absorption, Distribution, Metabolism and Excretion

AOP

Adverse Outcome Pathway

CI

Mitochondrial Complex I

CIII

Mitochondrial Complex III

COT

Committee on Toxicity of Chemicals in Food, Consumer Products and the Environment

DART

Developmental and Reproductive Toxicity

ECHA

European Chemicals Agency

EFSA

European Food Safety Authority

FAF

Food Additives and Flavourings

GLP

Good Laboratory Practice

IATA

Integrated Approaches to Testing and Assessment

KE

Key Event

LogP

Partition Coefficient Logarithm

MHA

2-Methylhexanoic Acid

MoA

Mechanism of Action

NAMs

New Approach Methodologies

N-NA

N-Nitrosamine

OECD

Organisation for Economic Cooperation and Development

SC

Scientific Committee

WoE

Weight of Evidence