Table 16
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Skip the menu of subheadings on this page.This is a paper for discussion. This does not represent the views of the Committee and should not be cited.
Table 16. Repeated dose toxicity studies for PFCAs - PFODA
*Derived by contractor; ** calculated according to EFSA. (2012); NR – not reported; NA – not applicable.
|
Substance / CAS no. / purity / reference |
Strain & species / sex / no. of animals |
Dose (mg/kg bw/day) / vehicle / route of admin / duration / Guideline (GL) study / Good Laboratory Practice (GLP) status |
PFAS concentration (µg/mL / µg/g) |
Observed effects at LOAEL (controls vs treated groups). Recovery (controls vs treated groups). |
|
PFODA CAS No. 16517-11-6 98.9%. Hirata-Koizumi et al. (2012) |
Crl:CD (SD) rats. Male 12/dose.
Recovery Male and female 5/dose. |
0, 40, 200 or 1000. Carboxymethylcellulose sodium. Gavage, 42 days (males), 42-56 days (females), OECD 422, GLP study. Recovery group: 0 or 1000. Males: 14 days, Females: 14 days, (recovery group females were not mated). |
NR |
Males (mean ± SD): ↑ absolute liver weight (g): 10.9 ± 1.8 vs 15.8 ± 1.8. ↑ relative liver weight (%): 2.36 ± 0.28 vs 3.35 ± 0.14. ↑ centrilobular hypertrophy: 0 vs 12 (grade 2). Females (mean ± SD): ↑ relative liver weight (%): 3.32 ± 0.16 vs 3.8 ± 0.10. Recovery: Males: ↑ absolute liver weight (g): 11.9 ± 0.3 vs 18.3 ± 2.1. ↑ relative liver weight (%): 2.40 ± 0.06 vs 4.46 ± 0.42. ↑ cenrilobular hypertrophy: 0 vs 4 (grade 2); 0 vs 1 (grade 2). Females: ↑ absolute liver weight (g): 7.8 ± 0.2 vs 10.3 ± 1.2. ↑ relative liver weight (%): 2.4 ± 0.1 vs 3.96 ± 0.53. |