Table 14
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Skip the menu of subheadings on this page.This is a paper for discussion. This does not represent the views of the Committee and should not be cited.
Table 14. Repeated dose toxicity studies for PFCAs - PFTeDA
*Derived by contractor; ** calculated according to EFSA. (2012); NR – not reported; NA – not applicable.
|
Substance / CAS no. / purity / reference |
Strain & species / sex / no. of animals |
Dose (mg/kg bw/day) / vehicle / route of admin / duration / Guideline (GL) study / Good Laboratory Practice (GLP) status |
PFAS concentration (µg/mL / µg/g) |
Observed effects at LOAEL (controls vs treated groups). Recovery (controls vs treated groups). |
Published NOAEL / LOAEL (mg/kg bw/day) |
Study author comments |
Comments |
|
PFTeDA CAS No. not given 96.5%. Hirata-Koizumi (2015)
|
Crl:CD (SD) rats. Males and females 7/sex/dose. Recovery, group: Males and females, 5/sex/dose.
|
0, 1, 3 or 10 0.5% water solution of carboxy methylcellulose sodium. Gavage, Males: 42 days beginning 14 days prior mating. Females: 14 days prior to mating, gestation and to PND5 OECD 422 GLP. Recovery group: 0 or 10. Males: 14 days, Females: 14 days, (recovery group females were not mated). |
NR |
No data. |
No data. |
No data. |
No data. |