Statement on the potential risks from ergot alkaloids in the maternal diet

Abbreviations

COT/2026/01

Last updated: 19 January 2026

ACTH

Adrenocorticotropic hormone

ARfD

Acute reference dose

BfR

Bundesinstitut fuer Risikobewertung/German Federal Institute for Risk Assessment

BMDL

Benchmark Dose Lower Confidence Limit

CHO

Chinese hamster ovary

CLoA

Clavine oxidase

CNS

Central nervous system

COT

Committee on the Toxicity of Chemicals in Food, Consumer Products and the Environment

EAs

Ergot alkaloids

EFSA

European Food Safety Authority

Et

Ergotamine tartrate

EU

European Union

FAO

Food and Agriculture Organization of the United Nations

FSH

Follicle-stimulating hormone

GB

Great Britian

GI tract

Gastrointestinal tract

HBGV

Health based guidance value

5-HT

5-hydroxytryptamine

IARC

International Agency for Research on Cancer

i.v.

Intravenous

JECFA

Joint FAO/WHO Expert Committee on Food Additives

LA

Lysergic acid

LB

Lower bound

LC/MS/MS

Liquid Chromatography-Tandem Mass Spectrometry

LD

Lethal dose

LH

Luteinizing hormone

LO(A)EL       

Lowest observed (adverse) effect level

LOD

Limit of detection

LOQ

Limit of quantification

LSD

Lysergic acid diethylamide

mg/kg

Milligram per kilogram

miRNA

micro ribonucleic acid

Misc

Miscellaneous

ML

Maximum levels

MoS

Margin of Safety

NDNS

National Diet and Nutrition Survey

ng/g

Nanogram per gram

NI

Northern Ireland

NO(A)EL

No observed adverse effect level

PRL

Prolactin

SACN

Scientific Advisory Committee on Nutrition

s.c.

Subcutaneous

SCE

Sister chromatid exchange

St

Salmonella typhimurium

(F)T4

(Free) thyroxine

TDI

Tolerable daily intake

TDS

Total Diet Study

TSH

Thyroid-stimulating hormone

UB

Upper bound

UF

Uncertainty factor

WHO

World Health Organisation

μg

μg = microgram

μg/g

microgram per gram

μg/kg

microgram per kilogram

μg/L

microgram per litre