Review of toxicity for endpoints identified by the COT

119.  The following endpoints were reviewed, initially by the COT and then in more detail by a sub-group of COT Members: aberrant crypt foci (as a potential marker for carcinogenicity), genotoxicity (also reviewed by COM), inflammation and immunotoxicity, allergenicity, reproductive and developmental toxicity and neurotoxicity. The COT’s reviews are discussed in detail in each of these sections for the endpoints.