COT FSA PBPK for Regulators Workshop Report 2021

Abbreviations - 2021 Workshop Report

Last updated: 11 April 2024

ADME

Absorption, Distribution, Metabolism and Excretion

BfR    

Bundesinstitut für Risikobewertung-The German Federal Institute for Risk Assessment

COT

Committee on Toxicity of Chemicals in Food, Consumer Products and the Environment

EFSA

European Food Standards Authority

EMA  

European Medicines Agency

FSA   

Food Standards Agency

GSA  

Global sensitivity analysis

INTEGRA

Integrated External and Internal Exposure

IPCS            

International Programme on Chemical Safety

IVIVE

In vitro to in vivo extrapolation

JPMDA

Japanese Pharmaceuticals and Medical Devices Agency

MCSim

Monte Carlo Simulation

MoA

Mode of action

MoE

Margin of exposure

NAM

New approach methodology

NGRA

Next generation risk assessment

NLME

Non-linear mixed effects

NOAEL

No-observed adverse effect level

OECD

Organisation for Economic Co-operation and Development

PBPK

Physiologically based pharmacokinetic modelling

PFOA

Perfluorooctanesulfonic acid

PFOS

Perfluorooctanoic acid

PK

Pharmacokinetics

PLETHEM   

Population Life-course Exposure to Health Effects Model

POD  

Point of departure

QIVIVE

Quantitative in vitro to in vivo extrapolation

SA     

Sensitivity analysis

SCCS

Scientific Committee on Consumer Safety

SME            

Small and medium-sized enterprises

TK     

Toxicokinetics

UA     

Uncertainty analysis

US EPA

United States Environmental Protection Agency

US FDA

United States Food and Drug Administration

WHO           

World Health Organisation