Overall Conclusion

This is a paper for discussion. This does not represent the views of the Committee and should not be cited.

79.             Overall, the COT agreed with the broad consensus of other authoritative bodies that the Price et al., 1996 rat developmental toxicity study was the most appropriate basis for a HBGV. A dose of 10.0 mg B/kg bw/day was identified as an appropriate POD, consistent with the COT’s previous assessment in 1995. Applying a default uncertainty factor of 100 to the POD results in a Tolerable Daily Intake (TDI) of 0.1 mg/kg bw/day

COT Month 2025

Statement 2025/XX