Statement on the Safety of Ginger Supplement Use in Pregnancy

References

COT/2025/01

Last updated: 22 May 2025

Abudayyak, M., Özdemir Nath, E., & Özhan, G. (2015). Toxic potentials of ten herbs commonly used for aphrodisiac effect in Turkey. Turkish journal of medical sciences, 45(3), 496–506. https://doi.org/10.3906/sag-1401-153

AlAskar, A; Shaheen, NA; Khan, AH; AlGhasham, N; Mendoza, MA; Matar, DB; Gmati, G; AlJeraisy, M; AlSuhaibani, A: (2020). Effect of daily ginger consumption on platelet aggregation. Journal of Herbal Medicine. Volume 20, 100316. https://doi.org/10.1016/j.hermed.2019.100316

Alnaqeeb MA, Thomson M, Al-Qattan KK, Kamel F, Mustafa T, Ali M. (2003): Biochemical and histopathological toxicity of an aqueous extract of ginger. Kuwait J Sci Eng, 30: 35-48.

Al Omari, I; Afifi, F; Salhab, A. (2012). Therapeutic Effect and Possible Herb Drug Interactions of Ginger (Zingiber officinale Roscoe, Zingiberaceae) Crude Extract with Glibenclamide and Insulin. Pharmacognosy Communications. 2. 12-20. DOI:10.5530/pc.2012.1.4

Ałtyn, I., & Twarużek, M. (2020). Mycotoxin Contamination Concerns of Herbs and Medicinal Plants. Toxins, 12(3), 182. https://doi.org/10.3390/toxins12030182

The Committee on Toxicity of Chemicals in Food, Consumer Products and the environment (COT) (2020). Scoping Paper on Herbal Supplements Used in Pregnancy.

Belsito, M. D., Cohen, D. E., Klaassen, C. D., Liebler, D. C., Peterson, L. A., Shank, R. C., Snyder, P. W. (2021). Safety Assessment of Zingiber officinale (Ginger)–Derived Ingredients as Used in Cosmetics  Ginger.pdf

Bordia A, Verma SK, Srivastava KC, (1997). Effect of ginger (Zingiber officinale Rosc.) and fenugreek (Trigonella foenumgraecum L.) on blood lipids, blood sugar and platelet aggregation in patients with coronary artery disease. Prostaglandins Leukotrienses and Essential Fatty Acids. 56:379-84. https://doi.org/10.1016/s0952-3278(97)90587-1

Bryer, E. (2005). A literature review of the effectiveness of ginger in alleviating mild-to-moderate nausea and vomiting of pregnancy. Journal of midwifery & women's health, 50(1), e1-e3. https://doi.org/10.1016/j.jmwh.2004.08.023.

Chittumma, P., Kaewkiattikun, K., & Wiriyasiriwach, B. (2007). Comparison of the effectiveness of ginger and vitamin B6 for treatment of nausea and vomiting in early pregnancy: a randomized double-blind controlled trial. Journal-medical association of thailand, 90(1), 15. PMID: 14649969.

COT (The Committee on Toxicity of Chemicals in Food, Consumer Products and the Environment) (2021). The potential effects that ginger and ginger supplements may have during pregnancy and lactation.

Crozier, S. R., Robinson, S. M., Borland, S. E., Godfrey, K. M., Cooper, C., Inskip, H. M., & SWS Study Group. (2009). Do women change their health behaviours in pregnancy? Findings from the Southampton Women's Survey. Paediatric and perinatal epidemiology, 23(5), 446-453. DOI: 10.1111/j.1365-3016.2009.01036.x

Dietz, B. M., Hajirahimkhan, A., Dunlap, T. L., & Bolton, J. L. (2016). Botanicals and Their Bioactive Phytochemicals for Women's Health. Pharmacological reviews, 68(4), 1026-1073. DOI: 10.1124/pr.115.010843.

Dilokthornsakul, W., Rinta, A., Dhippayom, T., & Dilokthornsakul, P. (2022). Efficacy and safety of ginger regarding human milk volume and related clinical outcomes: a systematic review of randomized controlled trials. Complementary medicine research, 29(1), 67-73. https://doi.org/10.1159/000515630.

Dissabandara D.L.O., Chandrasekara M.S. (2007). Effects of prenatal ginger rhizome extract treatment on pregnancy outcome and postnatal development of Sprague Dawley rats. Ceylon J Med Sci 2007, 50: 1-7. DOI: 10.4038/cjms.v50i1.116.  

DTU Food Institute, (2019). The safety of pregnant women when ingesting ginger shots made from the root from real ginger (Zingiber officinale Roscoe). (Available in Danish only).

Dugasani, S., Pichika, M. R., Nadarajah, V. D., Balijepalli, M. K., Tandra, S., & Korlakunta, J. N. (2010). Comparative antioxidant and anti-inflammatory effects of [6]-gingerol,[8]-gingerol,[10]-gingerol and [6]-shogaol. Journal of ethnopharmacology, 127(2), 515-520. https://doi.org/10.1016/j.jep.2009.10.004.

Duley, L., Meher, S., Hunter, K. E., Seidler, A. L., & Askie, L. M. (2019). Antiplatelet agents for preventing preeclampsia and its complications. Cochrane database of systematic reviews, (10). DOI: 10.1002/14651858.CD004659.pub3.

Egashira, K; Sasaki, H; Higuchi, S; Ieiri, I (2012). Food-drug Interaction of Tacrolimus with Pomelo, Ginger, and Turmeric Juice in Rats, Drug Metabolism and Pharmacokinetics, Vol 27, 2, 242-247. https://doi.org/10.2133/dmpk.DMPK-11-RG-105.

ElMazoudy, R. H., Attia, A. A. (2018). Ginger causes subfertility and abortifacient in mice by targeting both estrous cycle and blastocyst implantation without teratogenesis. Phytomedicine, 50, 300-308. https://doi.org/10.1016/j.phymed.2018.01.021.

Ensiyeh, J.; Sakineh, M.A. (2009). Comparing ginger and vitamin b6 for the treatment of nausea and vomiting in pregnancy: A randomised controlled trial. Midwifery 2009, 25, 649–653. https://doi.org/10.1016/j.midw.2007.10.013.

European Commission (EC) (2023). Commission Regulation (EU) 2023/915 of 25 April 2023 on maximum levels for certain contaminants in food and repealing Regulation (EC) No 1881/2006 Publications Office.

EMA (European Medicines Agency) (2012): Assessment report on Zingiber Officinale Roscoe, rhizome; EMA/HMPC/577856/2010.

Finnish Food Authority, (2019). General Instructions on Safe Use of Foodstuffs.

Fischer-Rasmussen, W.; Kjaer, S.K.; Dahl, C.; Asping, U. (1991). Ginger treatment of hyperemesis gravidarum. Eur. J. Obstet. Gynecol. Reprod. Biol. 1991, 38, 19–24. https://doi.org/10.1016/0028-2243(91)90202-v.

Getaneh, A., Guadie, A., & Tefera, M. (2021). Levels of heavy metals in ginger (Zingiber officinale Roscoe) from selected districts of Central Gondar Zone, Ethiopia and associated health risk. Heliyon, 7(4), e06924. https://doi.org/10.1016/j.heliyon.2021.e06924.

Ghayur, M. N., & Gilani, A. H. (2005). Ginger lowers blood pressure through blockade of voltage-dependent calcium channels. Journal of cardiovascular pharmacology, 45(1), 74-80. DOI: 10.1097/00005344-200501000-00013.

Goroya K, Mitiku Z, Asresahegn Y, (2019). Determination of concentration of heavy metals in ginger using flame atomic absorption spectroscopy. Afr. J. Plant Sci. 13, 163–167. DOI: 10.5897/AJPS2019.1787.

Healthline (2020). Ginger Tea in Pregnancy: Benefits, Safety, and Directions: Ginger Tea in Pregnancy: Benefits, Safety, and Directions.

Heitmann, K., Nordeng, H., & Holst, L. (2013). Safety of ginger use in pregnancy: results from a large population-based cohort study. European journal of clinical pharmacology, 69, 269-277. DOI: 10.1007/s00228-012-1331-5

Hosseini, E; Jahandidea, A; Mehrabani, D. (2015). Effect of alcoholic extract of Ginger during fetal life and breastfeeding on serum level of testosterone, LH, FSH and spermatogenic cells line in male mature offspring rats. Journal of Gorgan University of Medical Sciences,17:29-34.

Inskip HM, Godfrey KM, Robinson SM, Law CM, Barker DJP, Cooper C, et al. Cohort profile: The Southampton Women′s Survey. International Journal of Epidemiology. 2006; 35:42–48. [PubMed: 16195252] doi: 10.1093/ije/dyi202.

Jeena, K., Liju, V. B., & Kuttan, R. (2011). A preliminary 13-week oral toxicity study of ginger oil in male and female Wistar rats. International Journal of Toxicology, 30(6), 662-670. https://doi.org/10.1177/1091581811419023.

Jewell D, Young G. (2003). Interventions for nausea and vomiting in early pregnancy. Cochrane Database of Systematic Reviews, 2003, Issue 4. Art. No.: CD000145. DOI:10.1002/14651858.CD000145.

Jiang, X., Williams, K. M., Liauw, W. S., Ammit, A. J., Roufogalis, B. D., Duke, C. C., Day, R. O., & McLachlan, A. J. (2005). Effect of ginkgo and ginger on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects. British journal of clinical pharmacology, 59(4), 425–432. https://doi.org/10.1111/j.1365-2125.2005.02322.x .

Jolad, S. D., Lantz, R. C., Chen, G. J., Bates, R. B., & Timmermann, B. N. (2005). Commercially processed dry ginger (Zingiber officinale): composition and effects on LPS-stimulated PGE2 production. Phytochemistry, 66(13), 1614-1635. https://doi.org/10.1016/j.phytochem.2005.05.007.

Jolad, S. D., Lantz, R. C., Chen, G. J., Bates, R. B., & Timmermann, B. N. (2005). Commercially processed dry ginger (Zingiber officinale): composition and effects on LPS-stimulated PGE2 production. Phytochemistry, 66(13), 1614-1635. https://doi.org/10.1016/j.phytochem.2004.06.008.

Karagözoğlu, Y., & Kıran, T. R. (2023). Investigation of Heavy Metal Contents in Thyme (Thymus vulgaris) and Ginger (Zingiber officinale) Sold in Bingöl Herbalists. Middle Black Sea Journal of Health Science, 9(1), 88-97. https://doi.org/10.19127/mbsjohs.1203882.

Kaygusuz, M., Gümüştakım, R. Ş., Kuş, C., İpek, S., & Tok, A. (2021). TCM use in pregnant women and nursing mothers: A study from Turkey. Complementary Therapies in Clinical Practice, 42, 101300. https://doi.org/10.1016/j.ctcp.2020.101300.

Kilic, S., & Soylak, M. U. S. T. A. F. A. (2020). Determination of trace element contaminants in herbal teas using ICP-MS by different sample preparation method. Journal of food science and technology, 57, 927-933. DOI: 10.1007/s13197-019-04125-6.

Kim EC, Min JK, Kim TY, Lee SJ, Yang HO, Han S, Kim YM, Kwon YG, (2005). [6]-Gingerol, a pungent ingredient of ginger, inhibits angiogenesis in vitro and in vivo Biochemical and Biophysical Research Communications. 335:300-8. DOI: 10.1016/j.bbrc.2005.07.076.

Kim, IS, Kim, SY, Yoo, HH (2012). Effects of an aqueous-ethanolic extract of ginger on cytochrome P450 enzyme-mediated drug metabolism. Die Pharmazie67(12), 1007–1009. https://doi.org/10.1691/ph.2012.2595.

Kimura Y, Ito H, Hatano T (2010). Effects of mace and nutmeg on human cytochrome P450 3A4 and 2C9 activity. Biol Pharm Bull. 2010;33(12):1977-82. PMID: 21139236. DOI: 10.1248/bpb.33.1977.

Krüth P, Brosi E, Fux R, Mörike K, Gleiter CH (2004). Ginger-Associated Overanticoagulation by Phenprocoumon. Ann Pharmacother. Feb;38(2):257-60. doi: 10.1345/aph.1D225.

Laekeman, G. M., Van Calsteren, K., Devlieger, R., Sarafanova, E., Van Limbeek, J., & Dierckxsens, Y. (2021). Ginger (Zingiber officinale) root extract during pregnancy: a clinical feasibility study. Planta Medica, 87(10/11), 907-912.

DOI: 10.1055/a-1386-8848

Lantz, R. C., Chen, G. J., Sarihan, M., Sólyom, A. M., Jolad, S. D., & Timmermann, B. N. (2007). The effect of extracts from ginger rhizome on inflammatory mediator production. Phytomedicine: international journal of phytotherapy and phytopharmacology, 14(2-3), 123–128. https://doi.org/10.1016/j.phymed.2006.03.003

Lamxay, V., de Boer, H. J., & Björk, L. (2011). Traditions and plant use during pregnancy, childbirth and postpartum recovery by the Kry ethnic group in Lao PDR. Journal of Ethnobiology and Ethnomedicine, 7, 1-16.

DOI: 10.1186/1746-4269-7-14

Lippolis V, Irurhe O, Porricelli, ACR, Cortese M, Schena R, Imafidon T, Oluwadun A, Pascale M (2017). Natural co-occurrence of aflatoxins and ochratoxin A in ginger (Zingiber officinale) from Nigeria. Food Control 2017, 73, 1061–1067. https://doi.org/10.1016/j.foodcont.2016.10.026

Lumb A. B. (1994). Effect of dried ginger on human platelet function. Thrombosis and haemostasis, 71(1), 110–111. PMID: 8165628 DOI:10.1055/s-0038-1642392

Luo, L., Zhu, S., Akbari, A., & Tan, B. (2022). Ginger could improve gestational diabetes by targeting genes involved in nutrient metabolism, oxidative stress, inflammation, and the WNT/β-Catenin/GSK3β signaling pathway. Natural Product Communications, 17(12). https://doi.org/10.1177/1934578X221141276  

Malik, Z. A., & Sharmaa, P. L. (2011). Attenuation of high-fat diet induced body weight gain, adiposity and biochemical anomalies after chronic administration of ginger (Zingiber officinale) in Wistar rats. DOI:10.3923/IJP.2011.801.812

Matthews A., Haas D. M., O'Mathúna D. P., & Dowswell T. (2015). Interventions for nausea and vomiting in early pregnancy. Cochrane Database of Systematic Reviews, (9). https://doi.org/10.1002/14651858.CD007575.pub4

Mohammed O.J., Latif M.L., Pratten M.K. (2016). Evaluation of embryotoxicity for major components of herbal extracts using the chick embryonic heart micromass and mouse D3 embryonic stem cell systems. Reproductive Toxicology, Vol 59, 2016, 117-127, ISSN 0890-6238, https://doi.org/10.1016/j.reprotox.2015.12.003.

Mother and Baby (2022) Ginger & ginger tea in pregnancy: Is it safe?

Mukkavilli, R., Gundala, S. R., Yang, C., Donthamsetty, S., Cantuaria, G., Jadhav, G. R., Vangala, S., Reid, M. D., & Aneja, R. (2014). Modulation of cytochrome P450 metabolism and transport across intestinal epithelial barrier by ginger biophenolics. PloS one, 9(9), e108386. https://doi.org/10.1371/journal.pone.0108386 .

Nagabhushan M, Amonkar AJ, Bhide SV, (1987). Mutagenicity of gingerol and shogaol and antimutagenicity of zingerone in Salmonella/microsome assay. Cancer Letters. 36:221-33. https://doi.org/10.1016/0304-3835(87)90094-2.

Nakamura H, Yamamoto T, (1982). Mutagen and anti-mutagen in ginger, Zingiber officinale. Mutation Research. 103:119-26. https://doi.org/10.1016/0165-7992(82)90016-1.  

Nakamura H, Yamamoto T, (1983). The active part of the [6]-gingerol molecule in mutagenesis. Mutatation Research. 122:87-94. https://doi.org/10.1016/0165-7992(83)90043-x.

Nirmala, K., Prasanna Krishna T. and Polasa, K. (2007). In vivo Antimutagenic Potential of Ginger on Formation and Excretion of Urinary Mutagens in Rats. International Journal of Cancer Research, 3: 134-142. DOI: 10.3923/ijcr.2007.134.142.

NICE (2021). Antenatal care. Management of nausea and vomiting in pregnancy:  NG201 Evidence review R.

NHS (2024) Vomiting and morning sickness: Vomiting and morning sickness - NHS

NHS (2021) Women and Health: Nausea and vomiting in pregnancy.

NHS Specialist Pharmacy Service (2022). Herbal medicines: safety during pregnancy: Page not found – SPS - Specialist Pharmacy Service – The first stop for professional medicines advice.

Okonta JM, Uboh M, Obonga WO. (2008). Herb-drug interaction: a case study of effect of ginger on the pharmacokinetic of metronidazole in rabbit. Indian J Pharm Sci. 2008 Mar-Apr;70(2):230-2. PMID: 20046719; PMCID: PMC2792472. doi: 10.4103/0250-474X.41462.

Omotayo, O. P., Omotayo, A. O., Babalola, O. O., & Mwanza, M. (2019). Comparative study of aflatoxin contamination of winter and summer ginger from the Northwest Province of South Africa. Toxicology reports, 6, 489–495. https://doi.org/10.1016/j.toxrep.2019.05.011.

Pan, M. H., Hsieh, M. C., Hsu, P. C., Ho, S. Y., Lai, C. S., Wu, H., ... & Ho, C. T. (2008). 6Shogaol suppressed lipopolysaccharideinduced upexpression of iNOS and COX2 in murine macrophages. Molecular nutrition & food research, 52(12), 1467-1477. https://doi.org/10.1002/mnfr.200700515.

Park, S. A., Park, I. H., Cho, J. S., Moon, Y. M., Lee, S. H., Kim, T. H., ... & Lee, H. M. (2012). Effect of [6]-gingerol on myofibroblast differentiation in transforming growth factor beta 1–induced nasal polyp–derived fibroblasts. American Journal of Rhinology & Allergy, 26(2), 97-103. https://doi.org/10.2500/ajra.2012.26.3736.

Patti, G., De Caterina, R., Abbate, R., Andreotti, F., Biasucci, L. M., Calabrò, P., ... & Zimarino, M. (2014). Platelet function and long-term antiplatelet therapy in women: is there a gender-specificity? A ‘state-of-the-art’paper. European heart journal, 35(33), 2213-2223. https://doi.org/10.1093/eurheartj/ehu279.

Peneme B.M.L., Akassa, H., Ondélé, R., Lanzah A, B., Backala, A., Etou Ossibi, A. W., and Abena, A. A., (2023). Effects of the Aqueous Extract of the Rhizomes of Zingiber officinale (Ginger) on Sexual Parameters in Female Wistar Rats. European Journal of Medicinal Plants, 34(10), 1-11. https://doi.org/10.9734/ejmp/2023/v34i101161.

Plengsuriyakarn, T.; Viyanant, V.; Eursitthichai, V.; Tesana, S.; Chaijaroenkul, W.; Itharat, A.; Na-Bangchang, K. (2012). Cytotoxicity, Toxicity, and Anticancer Activity of Zingiber Officinale Roscoe Against Cholangiocarcinoma, Asian Pacific Organization for Cancer Prevention, 13(9), pp. 4597–4606. https://doi.org/10.7314/apjcp.2012.13.9.4597.

Portnoi, G., Chng, L. A., Karimi-Tabesh, L., Koren, G., Tan, M. P., & Einarson, A. (2003). Prospective comparative study of the safety and effectiveness of ginger for the treatment of nausea and vomiting in pregnancy. American Journal of Obstetrics and Gynecology, 189(5), 1374–1377. https://doi.org/10.1067/s0002-9378(03)00649-5.

Qiu, J. X., Zhou, Z. W., He, Z. X., Zhang, X., Zhou, S. F., & Zhu, S. (2015). Estimation of the binding modes with important human cytochrome P450 enzymes, drug interaction potential, pharmacokinetics, and hepatotoxicity of ginger components using molecular docking, computational, and pharmacokinetic modeling studies. Drug design, development and therapy, 841-866. DOI:10.2147/DDDT.S74669.

Raoufi, M. F., Farahani, T. M., Jadidi, E. S. M. S., & Gardeshi, T. M. (2023). Protective Effects of Ginger Extract on Oxidative Stress and Steroidogenesis-related Genes in The Ovary of Streptozotocin-induced Diabetic Rats. International Journal of Medical Laboratory.  https://doi.org/10.18502/ijml.v10i3.13750.

Rong, X., Peng, G., Suzuki, T., Yang, Q., Yamahara, J., & Li, Y. (2009). A 35-day gavage safety assessment of ginger in rats. Regulatory Toxicology and Pharmacology, 54(2), 118-123. https://doi.org/10.1016/j.yrtph.2009.03.002.

Rubin D, Patel V, Dietrich E. (2019). Effects of Oral Ginger Supplementation on the INR. Case Rep Med. Jun 11; 2019:8784029. PMID: 31281366; PMCID: PMC6594244. doi:10.1155/2019/8784029.

Shalaby, M.A.; Hamowieh, A.R. (2010) Safety and efficacy of Zingiber officinale roots on fertility of male diabetic rats, Food and Chemical Toxicology, Vol 48, Issue 10, 2920-2924, https://doi.org/10.1016/j.fct.2010.07.028.

Smith, C; Crowther, C; Willson, K; Hotham, N; McMillian, V. (2004). A Randomized Controlled Trial of Ginger to Treat Nausea and Vomiting in Pregnancy. Obstetrics and Gynecology. 103. 639-45. DOI: 10.1097/01.

Soudamini KK, Unnikrishnan MC, Sukumaran K, Kuttan R (1995). Mutagenicity and anti-mutagenicity of selected spices. Indian J Physiol Pharmacol, 39: 347-353.

Srivas K. C. (1984). Effects of aqueous extracts of onion, garlic and ginger on platelet aggregation and metabolism of arachidonic acid in the blood vascular system: in vitro study. Prostaglandins, leukotrienes, and medicine, 13(2), 227–235. https://doi.org/10.1016/0262-1746(84)90014-3.

Srivastava KC (1986). Isolation and effects of some ginger components of platelet aggregation and eicosanoid biosynthesis. Prostaglandins Leukot Med. Dec;25(2-3): 187-98. https://doi.org/10.1016/0262-1746(86)90065-x.

Srivastava KC (1989). Effect of onion and ginger consumption on platelet thromboxane production in humans. Prostaglandins Leukot Essent Fatty Acids. Mar; 35(3):183-5. doi: 10.1016/0952-3278(89)90122-1 PMID: 2710801.

Stanisiere, J., Mousset, P. Y., & Lafay, S. (2018). How Safe Is Ginger Rhizome for Decreasing Nausea and Vomiting in Women during Early Pregnancy? Foods (Basel, Switzerland), 7(4), 50. https://doi.org/10.3390/foods7040050.

Suekawa M, Yuasa K, Isono M, Sone H, Ikeya Y, Sakakibara I, Aburada M, Hosoya E, (1986). [Pharmacological studies on ginger. IV. Effect of (6)-shogaol on the arachidonic cascade] (in Japanese). Nihon Yakurigaku Zasshi, 88:263-9. https://doi.org/10.1254/fpj.88.263.

Thomson M, Al-Qattan KK, Al-Sawan SM, Alnaqeeb MA, Khan I, Ali M (2002). The use of ginger (Zingiber officinale Rosc.) as a potential anti-inflammatory and antithrombotic agent. Prostaglandins Leukot Essent Fatty Acids. Dec; 67(6):475-8. DOI: 10.1054/plef.2002.0441.

Tiran, D. (2012). Ginger to reduce nausea and vomiting during pregnancy: Evidence of effectiveness is not the same as proof of safety. Complementary Therapies in Clinical Practice 18 (2012) 22-25. https://doi.org/10.1016/j.ctcp.2011.08.007.

Verma, S. K., Singh, J., Khamesra, R., & Bordia, A, (1993). Effect of ginger on platelet aggregation in man. The Indian journal of medical research, 98, 240–242. https://doi.org/10.1016/j.hermed.2019.100316.

Vutyavanich T, Kraisarin T, Ruangsri R. (2001). Ginger for nausea and vomiting in pregnancy: randomized, double-masked, placebo-controlled trial. Obstet Gynecol. 2001 Apr;97(4): 577-82. DOI: 10.1016/s0029-7844(00)01228-x. PMID: 11275030.

Wagesho Y, Chandravanshi BS, (2015). Levels of essential and non-essential metals in ginger (Zingiber officinale) cultivated in Ethiopia. SpringerPlus 4, 1–13. Doi: https://doi.org/10.1186/s40064-015-0899-5.

Weidner MS, Sigwart K, (2001). Investigation of the teratogenic potential of a Zingiber officinale extract in the rat. Reproductive Toxicology, 15: 75-80. https://doi.org/10.1016/S0890-6238(00)00116-7.

Wen J, Kong W, Hu Y, Wang J, Yang M (2014). Multi-Mycotoxins analysis in ginger and related products by UHPLC-FLR detection and LC-MS/MS confirmation. Food Control 2014, 43, 82–87. doi:10.1016/j.foodcont.2014.02.038.

Wilkinson, JM, (2000). Effect of ginger tea on the fetal development of Sprague-Dawley rats. Reproductive Toxicology, 14(6), 507-512. DOI: 10.1016/s0890-6238(00)00106-4.

Willetts KE, Ekangaki A, Eden JA. (2003). Effect of a ginger extract on pregnancy-induced nausea: a randomised controlled trial. Aust N Z J Obstet Gynaecol. 2003 Apr;43(2):139-44. doi: 10.1046/j.0004-8666.2003.00039.x. PMID: 14712970.

Xu J, Zhang J, Lv Y, Xu K, Lu S, Xiaohui Liu, Yang Y, (2020). Effect of soil mercury pollution on ginger (Zingiber officinale Roscoe): Growth, product quality, health risks and silicon mitigation. Ecotoxicology and Environmental Safety, Volume 195, 2020, 110472, ISSN 0147-6513. https://doi.org/10.1016/j.ecoenv.2020.110472.

Young HY, Liao JC, Chang YS, Luo YL, Lu MC, Peng WH (2006). Synergistic effect of ginger and nifedipine on human platelet aggregation: a study in hypertensive patients and normal volunteers. The American Journal of Chinese Medicine. 34(4):545-551. DOI: 10.1142/s0192415x06004089.

Yu, Y., Zick, S., Li, X., Zou, P., Wright, B., & Sun, D. (2011). Examination of the pharmacokinetics of active ingredients of ginger in humans. The AAPS journal, 13(3), 417–426. https://doi.org/10.1208/s12248-011-9286-5.  

Zaeoung, S.; Plubrukarn, A.; Keawpradub, N. (2005) Cytotoxic and free radical scavenging activities of zingiberaceous rhizomes. Songklanakarin J. Sci. Technol. 2005, 27, 799–812. 11.Niwat_p799-812.

Zhang S, Kou X, Zhao H, Mak KK, Balijepalli MK, Pichika MR, (2002). Zingiber officinale var. rubrum: Red Ginger's Medicinal Uses. Molecules. 2022, 27, 775. https://doi.org/10.3390/molecules27030775.  

Zhang, W., & Lim, L. Y. (2008). Effects of spice constituents on P-glycoprotein-mediated transport and CYP3A4-mediated metabolism in vitro. Drug Metabolism and Disposition, 36(7), 1283-1290.  https://doi.org/10.1124/dmd.107.019737