Draft EFSA Scientific Opinion on the evaluation of the safety of preparations from the fruits of sweet and bitter fennel (Foeniculum vulgare Mill. and Foeniculum piperitum (Ucria) C.Presl)

Abbreviations

TOX/2025/34

Last updated: 29 August 2025

This is a paper for discussion. This does not represent the views of the Committee and should not be cited.

Acronym

Definition

ADI

Acceptable daily intake

ADME

Absorption, Distribution, Metabolism and Excretion

AMPAC

N-acetyl-S-[3′-(4-methoxyphenyl)allyl]-L-cysteine

BfR

German Federal Institute for Risk Assessment

BMD

Benchmark dose

BMDL10

Lower confidence limit for a benchmark response of 10%

COT

Committee on Toxicity of Chemicals in Food, Consumer Products and the Environment

CYP450

Cytochrome P450

DNA

Deoxyribonucleic acid

EC

European Commission

EFSA

European Food Safety Authority

EMA

European Medicines Agency

EU

European Union

HMPC

Committee on Herbal Medicinal Products

MoE

Margin of exposure

NDA

Panel on Nutrition, Novel Foods and Food Allergens

NTP

National Toxicology Programme

P90

90th percentile

P95

95th percentile

PBBD

Physiologically based biodynamic

PBBK

Physiologically based biokinetic

sQ

Subquestion

SULT

Sulfotransferase