COT/COM/COC Annual Report Index

A - Index

In this guide

Index to Subjects and Substances considered in previous annual reports of the Committees on Toxicity, Mutagenicity and Carcinogenicity of Chemicals in Food, Consumer Products and the Environment.

Subject:

Accelerator Mass Spectrometry

Year

Page

Accelerator Mass Spectrometry an aid to carcinogen risk assessment

2000

103

Subject:

Acceptable Daily Intakes (ADI)

Year

Page

Acceptable Daily Intakes (ADI)

1992

15

Subject:

Acetyl tributyl citrate (ATBC)

Year

Page

COM evaluation

1994

24

COM evaluation of additional data

1997

63

Subject:

Acid sweets

Year

Page

Adverse reactions to

2004

7, 25

Subject:

Aclonifen

Year

Page

COM evaluation of,

2008

227, 262

Subject: Acrylamide	Year	Page
COC evaluation of	1992	54
COM evaluation of	2007	130, 137
COM evaluation of (ongoing)	2008	235
COM evaluation of	2009	139, 153
EFSA consultation on a draft scientific opinion on acrylamide in food	2014	8, 44
in fried and baked food	2002	7
in the diet of infants and young children	2016	7
Pangenome analysis, published paper on	2019	51
Potatoes and acrylamide formation, WRAP study on	2020	17

Subject:

Acute toxicity testing

Year

Page

Evident toxicity as an endpoint in,

2007

19

Subject:

Ad hoc Expert Group on Vitamins and Minerals (EVM)

Year

Page

Formation of,

1997

6

Subject: Additives, food	Year	Page
and behaviour	2002	11
and hyperactivity	2000	27
in foods especially prepared for infants and young children	1991	22
in infant formulae and follow-on formulae	1991	14
Guar gum	1991	14
Carcinogenicity of food additives (T01040/41), FSA funded research on health effects of	2008	10, 204
Carcinogenicity of food contaminants and additives	2004	15
consideration of FSA-funded research on joint endocrine effects of multi-component mixtures of food contaminants and additives	2010	16

Subject:

Advances in toxicology

Year

Page

21st Century Toxicology

2009

35

Subject:

Adverse birth outcomes

Year

Page

Epidemiological studies of landfill and,

2007

24

Subject:

Adverse Outcome Pathways

Year

Page

presentation on

2017

52

Germ cell adverse outcome pathways

2016

34

Subject:

Advisory Committee on Novel Foods and Processes (ACNFP),

Year

Page

joint meeting of COT with

1991

21

Subject: Agaritine	Year	Page
COM evaluation of,	1992	36,
COC evaluation of	1992	54
COC evaluation of	1996	34

Subject: Aircraft cabin air environment, ill-health in aircraft crew and the possible relationship to smoke/fume events in aircraft	Year	Page
Organophosphates and oil/hydraulic fluid pyrolysis products	2006	19
Updated COT evaluation of literature, measuring air contaminants	2007	7, 66
COT evaluation of	2013	7

Subject:

Air fresheners

Year

Page

Potential respiratory effects of

2008

7

Subject: Air pollution	Year	Page
Polycyclic aromatic hydrocarbons in air pollution	2004	183
Ranking of carcinogens: comparison of method using some air pollutants	2001	119
Quantification of risk associated with carcinogenic air pollutants	2002	128
Risks associated with exposure to low levels of air pollution	2003	193

Subject:

Air quality guidelines

Year

Page

Genotoxins, consideration of

1992

58

Subject: Alcohol and alcoholic beverages (also see ethanol)	Year	Page
Mutagenicity	1995	28
Carcinogenicity	1995	46
Evaluation of sensible drinking message	1995	58
and breast cancer , COC Ongoing evaluation of	2002	133
and breast cancer , COC Ongoing evaluation of	2003	196
and breast cancer , COC evaluation of	2004	173, 194
Alcohol attributable burden of cancer	2011	56
and cancer risk , COC ongoing review of	2013	58
and cancer risk , COC review of	2016	43
Mechanism of carcinogenicity in humans	1995	57
and squamous cell carcinoma: review of the quantitative relationship	2005	139
effects on the epigenome in the germline: role in the inheritance of alcohol-related pathology	2017	53
Potential role of oxidative damage in alcohol’s mutagenic and carcinogenic mode of action	2015	36
Presentation on initial preliminary results of meta-analysis of alcohol and breast cancer	2001	120
Review of the mutagenicity of alcohol	2015	35
Sensible drinking message, Evaluation of	1995	58
Statement of consumption of alcoholic beverages and risk of cancer	2015	44
Statement on the mutagenicity of alcohol(ethanol) and its metabolite acetaldehyde	2015	35
Ongoing work on the COT contribution to the SACN risk assessment on nutrition and, alcohol; 2016 Chief Medical Officers Report	2021	31

Subject: Alitame	Year	Page
COM evaluation of	1992	36
COT evaluation of	1999	7
COT evaluation of additional data	2000	10

Subject: Almond drinks	Year	Page
in the diet of infants aged 1-5	2019	19
in the diet of infants aged 1-5	2020	29
Statement on the consumption of plant-based drinks (almond, soya, oat)	2021	11

Subject:

Alternaria toxins

Year

Page

Mutagenicity of

1991

50

Subject: Allergenic foods	Year	Page
timing of introduction to the infant diet and influence on the risk of development of atopic outcomes and autoimmune disease	2016	16
maternal and infant dietary exposures and,	2017	26
Allergenic foods, COT/SACN Subgroup on the timing of introduction into the infant diet	2017	20
Peanut butter during weaning	1998	17
Risks of chemical toxicity and allergic disease in relation to infant diet	2012	14

Subject:

Aluminium

Year

Page

in the diet of infants and young children

2016

8

Subject:

Amalgam, Dental

Year

Page

COT review of

1997

13

Subject:

Amano 90 (enzyme)

Year

Page

COT evaluation of

2000

15

Subject:

Ammonium Phosphatides (Emulsifier YN)

Year

Page

COT evaluation of

1994

7

Subject:

Amnesic Shellfish Poisoning

Year

Page

Atypical results in the lipophilic mouse bioassay

2001

7

Subject: Aneuploidy	Year	Page
inducing chemicals	1993	36
Thresholds for	Year	Page
COM evaluation of	1995	37
COM evaluation of	1996	42
ECETOC Monograph on	1997	78

Subject:

Aniline

Year

Page

COM review of

1992

40

Subject:

Antimony trioxide

Year

Page

COM review of

1997

62

Subject: Arsenic	Year	Page
in diet of infants and young children	2016	10
in drinking water	1994	32
in food, opinion of the European Food Safety Authority	2009	8
In seaweed – urgent advice	2004	13, 22
Total and inorganic in food: results of the 1999 Total Diet Study (ongoing)	2002	20
Total and inorganic in food: results of the 1999 Total Diet Study	2003	7

Subject: Asbestos	Year	Page
COC evaluation of	2011	57
relative vulnerability of children to	2013	52
Ascorbyl palmitate	1991	15
relative vulnerability of children to	2012	46

Subject: Aspartame	Year	Page
COT statement on	1992	12
COC evaluation of	1996	56
Entry to be confirmed	2006	280, 287
EFSA evaluation of,	2013	13,
FSA double blinded study of	2013	14

Subject:

Astaxanthin

Year

Page

in farmed fish

1991

15

Subject:

Autoimmune disease

Year

Page

Risks arising from the infant diet and the development of

atopic and autoimmune disease

2012

21

Subject:

Avoparcin

Year

Page

COC review of

1992

56

Subject:

Azodicarbonamide

Year

Page

COT evaluation of

1994

6

COT evaluation of

2019

36

COT/COM/COC Annual Report Index

B - Index

In this guide

Subject:

Benchmark dose modelling in risk assessment

Year

Page

EFSA consultation on draft guidance document on the use of

2016

17

Subject:

Benz(a)pyrene

Year

Page

in drinking water

1994

35

Subject: Benzene	Year	Page
COC evaluation of	1991	45
Induced carcinogenicity	1997	114
Consideration of evidence for a threshold	1998	32

Subject:

Benzimidazoles

Year

Page

Consideration of a common mechanism group

2007

130

Subject: Betal quid, pan masala and areca nut chewing	Year	Page
COC evaluation	1994	36
COC evaluation of	2007	179
COC statement on	2008	276, 291

Subject: Biobank project	Year	Page
Presentation to COC	2003	194
Correspondence with	2004	192
Biological Relevance and Statistical Significance	2020	64

Subject:

Biologically based food contact materials

Year

Page

Position paper on the alternatives to conventional plastics for food & drinks packaging

2021

16

Subject:

Biomonitoring

Year

Page

Development of Human Biomonitoring Guidance Values in the HBM4EU project

2021

21, 75

Subject:

Biomonitoring studies for genotoxicity in pesticide applicators

Year

Page

Ongoing COM review of

2004

146

COM review of

2005

82;93;111

Subject:

Bisphenol A

Year

Page

Review of Nagel et al study

1997

6

in canned food

2001

8

Subject: Bisphenol A diglycidyl ether (BADGE)	Year	Page
COM review of	1996	35
Dietary survey of	1997	8
EFSA Consultation on a draft scientific opinion on the risks to public health	2014	9

Subject:

Bitter Apricot Kernels

Year

Page

cyanogenic glycosides in

2006

7,29

Subject:

Boron

Year

Page

in drinking water and food

1995

6

Subject:

Bracken

Year

Page

COM review of

1993

33

COT statement on risks from eating foods derived from animals who have consumed bracken

2008

8, 49

Subject: Breast cancer alcohol and	Year	Page
Ongoing COC evaluation of	2002	133
Ongoing COC evaluation of	2003	196
COC evaluation of	2004	173
Presentation on initial preliminary results of meta-analysis of alcohol and breast cancer	2001	120

Subject:

Breast cancer, organochlorine insecticides and

2004

180

Consideration of the epidemiology data on dieldrin, DDT and

certain hexachlorocyclohexane isomers

2004

223

Subject: Breast implants	Year	Page
Linked to breast cancer; Berkel et al., 1992 epidemiological study	1992	58
Containing soya bean oil	1999	7
Polyurethane coated	1994	36
PIP hydrogel, In breast implants	2000	30
Breast implants, altered formulation, updated COT evaluation	2002	16
Hydrogel filler for breast implants: Further studies	2005	9, 61

Subject: Breast milk	Year	Page
archive, toxicological evaluation of chemical analyses carried out as part of a pilot study for a	2004	14, 70
PCBs in,	2001	19
proposal for a breastmilk analysis study using pre-existing samples held by Imperial College London.	2017	26

Subject:

Bromate

Year

Page

In drinking water, carcinogenicity and genotoxicity

1993

50

in bottled water – urgent advice

2004

14

Subject: Brominated compounds	Year	Page
Bromine	2000	17
Bromodichloromethane	1994	22
Bromoform	1994	23, 33
flame retardants in fish from the Skerne-Tees river system	2003	8
Organic contaminants: Preliminary discussion on toxicological evaluation	2005	7

Subject:

Bromine, fluorine, and iodine

Year

Page

COT evaluation using 1997 Total Diet Study

2000

17

Subject:

1,3-Butadiene

Year

Page

As an in vitro and in vivo mutagen

1992

41, 58

human risk of heritable mutations

1998

33

Subject:

Butylated hydroxyanisole (BHA)

Year

Page

COT evaluation of

1992

16

Subject: Bystander Risk Assessment Working Group (BRAWG)	Year	Page
application of pesticides	2010	25
pesticide exposure assessment for regulatory risk assessment	2012	18
Recommendations of the Bystander Risk Assessment Working Group report concerning skin sensitisation from exposure to pesticides	2014	16
Workshop on Bystander Risk Assessment Working Group (BRAWG)	2011	26

COT/COM/COC Annual Report Index

C - Index

In this guide

Subject : Cadmium,	Year	Page
in the 2006 Total Diet Study in the infant diet	2009	12
establishing a revised Tolerable Weekly Intake (TWI)	2009	12
Comparing exposure to the TWI established in 2009	2018	9
ongoing work on the COT contribution to the SACN risk assessment on nutrition and, cadmium	2021	31

Subject: Caffeine	Year	Page
Caffeine and alcohol: combined effects on health and behaviour	2012	7
EFSA consultation on a draft scientific opinion on the safety of caffeine	2015	7
Reproductive effects of	2001	22
Reproductive effects of	2007	24
Reproductive effects of	2008	14, 49

Subject:

Calcium-parathyroid hormone axis

Year

Page

Phosphate and the,

2004

11, 54

Subject:

Cancer

Year

Page

Oesophageal cancer

2004

178

The role of miRNA related effects and chemicals on cancer

2011

56

Subject:

Cancer aetiology

Year

Page

and causal inference.

2017

53

Subject: Cancer incidence near municipal solid waste incinerators	Year	Page
in Great Britain	2000	104
Update review of epidemiological studies on	2008	284
Review of	2009	240

Subject: Cancer risk	Year	Page
DNA adducts as a biomarker for	2008	277
Joint COC/COM symposium on genetic susceptibility to cancer	1998	35
Epidemiological data linking cancer and alcohol	1995	58
Modification of, COC discussion of	2021	76

Subject: Cannabidiol (CBD)	Year	Page
Cosmetic products, potential risks from use of topically applied CBD-containing	2020	28
COT review of,	2019	16, 36
Genotoxicity of, COM evaluation	2020	50
Inhalation, potential adverse effects associated with exposure to CBD) by	2020	28
Position paper on CBD in food products	2020	11
Updated position paper on	2021	24

Subject:

Canned foods

Year

Page

Bisphenol A in

2001

8

Subject:

Captan (fungicide)

Year

Page

COM and COC Evaluation of

1993

35, 50

Subject:

Caramel (Type 1)

Year

Page

Evaluation of

1991

30

Subject:

Carbaryl

Year

Page

COM and COC Evaluation of

1995

30, 64

Subject:

Carbon nanotubes

Year

Page

Carcinogenicity of

2010

60

Carcinogenicity of

2011

58

Subject: Carcinogenesis	Year	Page
age-related differences in susceptibility to	2006	281
mode of action / human relevance framework	2005	134
mode of action / human Relevance Framework	2008	279
“Tissue Organisation Field Theory” of	2006	286
Carcinogenic air pollutants, Quantification of risk	2002	128
Carcinogenicity guidelines	1991	44

Subject: Carcinogens	Year	Page
COC guidance on a strategy for the risk assessment of	2004	188
Assessing the risks of acute or short-term exposure to	2007	179
Early life exposure- assessing susceptibility from EPA risk assessment guideline: supplemental data for	2003	195
Guidance Statements on the risk assessment of	2010	63
Occupational, HSE priority programme	2004	177
Insulin-like growth factor-1 (IGF-1) in the diet, The potential carcinogenic risk of	2009	78
Interaction between genotype and chemicals in the environment on the induction of cancer in risk assessment	2011	53
Risk assessment of carcinogens, Revised guidance	2003	197
COC guidance on a strategy for the risk assessment of carcinogens	2004	188
Single or short term exposure to carcinogens	2005	140
Use of target organ mutagenicity data in carcinogen risk assessment	2005	124
Organ mutagencity data in carcinogen risk assessment	2005	124

Subject: Carcinogenicity	Year	Page
Chemical carcinogenicity revisited	2019	50
Testing for carcinogenicity of pharmaceuticals	1997	112
Joint COM/COC on the significance of low level exposures to DNA adduct inducing chemicals	1996	48
‘Risk assessment methodologies and approaches for mutagenic and carcinogenic substances’, Preliminary Report by the EU Scientific Committees on Consumer Products, on Health and Environmental Risks, and on Emerging and Newly-Identified Risks on	2008	280

Subject: Carcinogenicity studies	Year	Page
in rats, Minimum duration of	2001	121
in rats, Minimum duration of	2002	130
OECD Guidance document for the performance of chronic toxicity and	2009	225
Revision of OECD Test Guidelines for	2008	282
tobacco products, testing of	2009	219
Longevity of carcinogenicity studies: consideration of a database prepared by the Pesticides Safety Directorate	2000	109
Nephropathy observed in a 2-year carcinogenicity study	2008	12
T25 to estimate carcinogenic potency	1995	72
Validation of short-term carcinogenicity tests using transgenic animals, Presentation on	1999	73

Subject: Carrageenan	Year	Page
Allergic food intolerance, COT evaluation of	1997	11
Immune system, possible effects due to uptake by the gut-associated lymphoid tissues.	1993	12
Infant formulae, COT evaluation of use in	1991	14

Subject:

Cell lines expressing human xenobiotic metabolising enzyme in mutagenicity testing

Year

Page

COM review of

1995

38

Subject: Cell transformation assays	Year	Page
COM review of	1994	26
COM review of	2012	44
For the prediction of carcinogens	2012	37

Subject:

Chemical risk assessment

Year

Page

Evolving approaches to,

2007

23, 38

Interaction between genotype and chemicals in the environment on the induction of cancer in risk assessment

2011

53

Subject: Childhood cancer	Year	Page
Age as an independent risk factor for chemically induced acute myelogenous leukaemia in children	2008	276
Childhood leukaemia and residence near sources of traffic exhaust and petrol fumes: review of the possible associations between	2005	143
Hazard proximities in Great Britain (from 1953 to 1980)	1997	110
Ongoing COC review of	2004	191
Ongoing COC review of	2005	134
Paternal smoking and	1997	68

Subject:

Children

Year

Page

Research project (T07040) investigating the effect of mixtures on certain food colours and a preservative on behaviour in

2007

8, 49

Children’s Environment and Health Strategy for the UK

2008

9

Subject:

Chlordecone

Year

Page

Endosulfan, pentachlorobenzene and in the infant diet

2013

18

Subject:

Chlorinated and brominated contaminants

Year

Page

in shellfish, farmed and wild fish

2006

10, 67

Subject: Chlorinated drinking water	Year	Page
Mutagenic activity of	1991	32
Epidemiology and cancer	1992	55
and cancer	Year	Page
Chlorinated drinking water	2007	185
Chlorinated drinking water	2008	278, 285
and reproductive outcomes	Year	Page
Chlorinated Drinking Water and	1998	8
Chlorinated drinking water and	2001	18
Chlorinated drinking water	2004	8, 46
Chlorinated paraffins in food	2009	13, 111
Chlorination disinfection by-products and risk of congenital anomalies in England and Wales – new SAHSU study	2008	9

Subject:

Chlorine and chlorine dioxide as flour treatment agents

Year

Page

COM review of

1993

33

COT and COM review of

1996

7, 36

Subject:

Chlorobenzenes

Year

Page

COT review of

1997

12

2-Chlorobenzylidene malonitrile (CS)	Year	Page
COT review of	1998	32
new formulation of, and PAVA (Nonivamide) sprays: combined use and CS Spray
new formulation of PAVA (Nonivamide) and CS Spray respectively	2017	28
Ongoing work, co-exposure	2005	17
co-exposure	2006	7, 21
Review of CS Spray as a chemical incapacitant in relation to potential public health concerns	1999	7, 51
Combined use of CS (2-chloro-benzylidene malonitrile) and PAVA (nonivamide) (captor 2) irritant sprays	2013	14

Subject:

Chlorodibromomethane and chloroform

Year

Page

See trihalomethanes in drinking water

1994

22, 23, 32

Subject:

Chlorophenols

Year

Page

COM review of genotoxicity

2011

45

genotoxicity of

2012

37

Subject:

Cholangiocarcinoma

Year

Page

Evidence for an increase in mortality rates from intrahepatic cholangiocarcinoma in England and Wales 1968-1996

2000

107

in the rat

2005

155

Subject:

Chromium picolinate

Year

Page

COM ongoing review of

2003

141

COM review of the available information on the mutagenicity of trivalent chromium and specifically on chromium picolinate

2004

135, 148

Subject:

Chromium VI

Year

Page

COM review of

2015

36

Subject:

Chrysotile-substitutes,

Year

Page

Carcinogenic risks

1998

50

Subject: Chymosin (enzyme)	Year	Page
from genetically modified Escherichia coli K12 in cheese manufacture	1991	16, 28
Enzyme submission to COT	2000	16
Enzyme submission; chymosin preparation derived from GM aspergillus niger var. awamori	2002	10

Subject:

Climate change

Year

Page

COC evaluation of

2011

52

Subject: COC guidance	Year	Page
Review of	2001	142
Revision of	2002	134
COC template	2002	129
COM template	2002	87
on a strategy for the risk assessment of carcinogens	2004	188

Subject: COM guidance	Year	Page
On ICH guidelines: Genotoxicity: A standard battery for genotoxicity testing of pharmaceuticals (S2B) and consideration of the mouse lymphoma assay	1997	75
Joint COM/COC on the significance of low level exposures to DNA adduct inducing chemicals	1996	48
Joint symposium with COM on use of target organ mutagenicity in carcinogen risk assessment	2004	192
Joint meeting of COT/COM on use of target organ mutagenicity assays in carcinogen risk assessment	2005	92, 124

Subject:

CONCAWE

Year

Page

Assessment of exposure to petrol vapour

2005

145

Assessment of exposure to benzene vapour

2005

146

Subject: Comet Assay	Year	Page
in mutagenicity testing strategies	1998	35
published literature on the use of this assay to detect chemical mutagens	1995	39
Statement on joint COC and COM meeting 9 June 2005	2005	125
Statement on a comparison of the relative performance of the in vivo rat liver UDS assay and the in vivo Comet assay	2006	249

Subject:

Comfrey

Year

Page

Report, pyrrolizidine alkaloid (PA), in vivo data

1992

19

results of a survey of comfrey

1994

7

Subject: Committee procedures	Year	Page
Code of Conduct for Observers	2007	18
Code of practice, revision of COT	2020	21
Code of Practice for Scientific Advisory Committees CoPSAC) second round of consultation	2001	106
Code of Practice for Scientific Advisory Committees, the updating of.	2007	18
Consultation document for updating the Code of Practice for Scientific Advisory Committees	2010	23
EFSA consultation on draft guidance on biological relevance	2017	17
EFSA consultation on draft guidance on the risk assessment of substances present in food intended for infants below 16 weeks of age	2017	19
EFSA consultation on draft guidance on weight of evidence	2017	18
EFSA opinion on statistical significance and biological relevance	2011	22
Draft EFSA protocol for a systematic review on health outcomes related to the age of introduction of complementary food for the scientific assessment of the appropriate age of introduction of complementary feeding into an infant’s diet	2017	20
EFSA consultation on draft EFSA/ECHA guidance for the identification of endocrine disruptors in the context of Regulations (EU) No 528/2012 and (EC) No 1107/2009	2018	17
EFSA consultation on draft guidance on risk assessment of the application of nanoscience and nanotechnologies in the food and feed chain: Part 1, human and animal health	2018	18
EFSA consultation on draft guidance on threshold of toxicological concern approach	2018	20
EFSA public consultation on draft Scientific Opinion on evaluation of the health risks related to the presence of cyanogenic glycosides in foods other than raw apricot kernels	2018	20
Public consultation on the EFSA Opinion on “Risk for animal and human health related to the presence of dioxins and dioxin-like PCBs in feed and food.”	2018	20
EFSA public consultation on the MIXTOX guidance	2018	21
EFSA safety assessment of certain flavouring substances, COM consideration	2018	42
EFSA consultation on genotoxicity of mixtures	2018	42
EFSA consultation on phthalates	2019	14
EFSA consultation on the EFSA opinion on risk to public health related to the presence of ochratoxin in food.	2020	22
EFSA Public consultation on the EFSA draft Opinion “Risk to human health related to the presence of perfluoroalkyl substances in food	2020	23
EFSA consultation on the EFSA opinion on risks for animals and human health related to the presence of glycoalkaloids in feed and food, in particular in potatoes and potato-derived products	2020	24
EFSA Public consultation on the EFSA draft “Update of the risk assessment of nickel in food and drinking water”	2020	25
EFSA consultation on the EFSA opinion on the update of the risk assessment of hexabromocyclododecanes (HBCDDs) in food	2020	26
EFSA recommendations on Default values to be used in risk assessment in the absence of actual measured data	2012	7
Review of the 2018 EFSA opinion on dioxins	2021	18
Review of the 2021EFSA opinion on titanium dioxide	2021	23
Draft EFSA Scientific Committee Opinion on scientific criteria for grouping chemicals into assessment groups for human risk assessment of combined exposure to multiple chemicals	2021	26
Draft EFSA Scientific Committee Opinion on biological plausibility of non-monotonic dose responses and their impact on the risk assessment	2021	27
EFSA draft opinion on “Identification and prioritisation for risk assessments of phthalates, structurally similar substances potentially used as plasticisers in materials and articles intended to come into contact with food” and “draft protocol for the exposure assessment as part of the safety assessment of phthalates, structurally similar substances potentially used as plasticisers in materials and articles intended to come into contact with food”	2021	28
Food Standards Agency review of scientific committees	2001	24
Good Practice Agreement for Scientific Advisory Committees	2006	16
Public Consultation on Code of Practice for Scientific Advisory Committees and Councils	,2021	29
Horizon Scanning: Multiple emerging or developing topics of importance within the COT / COM / COC remit.	Every year	Consult individual report
In the light of the Phillips enquiry (COC)	2001	9, 106
Open Meetings – review of procedure	2006	17
Peer review by EU-ANSA agencies	2017	20
Performance evaluation for Committee members	2006	17
Procedure for holding COT meetings in open session	2003	18
Quinquennial Review of the COT	2011	23
Reviews of risk procedures used by Government advisory Committees dealing with food (COM)	2000	22, 110
Second round of consultation	2003	12, 106
Uncertainty framework from a social science perspective	2011	25
WHO public consultation on the JECFA/JMPR update of Chapter 5 (EHC 240)	2020	26, 51

Subject: Committee workshops	Year	Page
Bystander Risk Assessment Working Group (BRAWG)	2011	26
Diet and drug interaction	2005	7
ECETOC workshop on use of T25 in chemical carcinogen evaluation	2001	141
Epigenetics in carcinogenesis	2016	42
Epigenetics, transgenerational	2008	19, 36
Exploring Dose- response	2020	21
Genotoxicity data, interpretation of	2020	48
ILSI/HESI workshop on less-than-lifetime exposure to carcinogens	2012	44
International workshop on the categorisation of mutagens	2001	108
PBPK for regulators	2020	22
Social Science insights for risk assessment	2006	17

Subject: Contaminants in the diet of infants and young children	Year	Page
Overarching statement.	2019	8
possible health risks from the exposure of infants to HBCDDs in breast milk, dust and food	2014	12
contaminants in- overarching statement.	2019	8

Subject: Contaminants in soil	Year	Page
assessing the possible risks to human health associated with exposure to	2001	10
Updated framework guidance, establishing a TDI	2008	9
new screening levels	2013	15, 54

Subject:

Copper

Year

Page

in the infant diet

2018

10

Subject:

Coumarin

Year

Page

And liver cancer, COT review of

1998

29, 41

Subject:

CRISPR gene editing technology-

Year

Page

potential for genotoxicity

2018

41

Subject:

CS Sabre 540010-01,

Year

Page

new formulation

2018

16

Subject:

Cyanogenic glycosides

Year

Page

in apricot kernels

2006

7, 29

EFSA public consultation on draft Scientific Opinion on evaluation of the health risks related to the presence of cyanogenic glycosides in foods other than raw apricot kernels

2018

20

Subject:

Cyclamate

Year

Page

COT review of

1995

6

Subject:

Cycloastragenol

Year

Page

COC evaluation of

2015

42

COT/COM/COC Annual Report Index

D - Index

In this guide

Subject:

Data, relevance and reliability of

Year

Page

Non-technical statement on how Committees assess

2021

22, 78

Subject:

Default values to be used in risk assessment in the absence of actual measured data

Year

Page

EFSA recommendations, COT discussion of

2012

7

Subject:

Dental amalgam

Year

Page

COC evaluation of

1997

13

Subject:

Dentists and dental nurses, olfactory neuroblastomas: possible association in

Year

Page

Preliminary data

2003

197

COC evaluation of

2004

179, 251

Subject:

Deoxenivalenol (DON)

Year

Page

Mutagenicity and

1991

50

Subject:

Developmental Neurotoxicity

Year

Page

Interpretation of studies

2009

14

Subject:

Dibenzo(a,l)pyrene

Year

Page

In air pollution

2003

189

Subject:

Dibutylphthalate (DBP)

Year

Page

in clogs

2010

9

Subject: 1,3-Dichloropropan and 2,3-dichloropropan-1-ol -2-ol	Year	Page
Carcinogenicity of	2004	243
COM review of	2003	128, 190
COM and COC review of	2001	99, 137
(new mutagenicity data)	2004	134, 148

Subject: Dichlorvos	Year	Page
COM review on the mutagenicity of	2001	82
COM evaluation update on genotoxicity and carcinogenicity, judicial review	2002	83
Threshold dose	2010	61
COC review of 2010 conclusions	2011	53

Subject:

Diesel exhaust

Year

Page

COC consideration of

1991

47

Update on carcinogenicity of

1996

62

Subject:

Diet and Drug Interactions

Year

Page

Workshop on

2005

7

COT statement on

2005

27

Subject:

Diet and nutrition surveys

Year

Page

National Diet and Nutrition Survey

2009

17

National Health And Nutrition Examination Survey(NHANES)

2010

16

Subject:

Dietary restriction

Year

Page

and carcinogenesis in rats

1991

51

Subject:

Di-2-ethylhexyl adipate (plasticizer)

Year

Page

COT consideration of

1991

17

COM consideration of

1991

28

Subject: Diethyl-m-toluamide (DEET)	Year	Page
review of toxicology literature on topical insect repellent diethyl-m-toluamide	2002	8
amendment to the published statement	2003	128
update of toxicology literature	2006	8, 37

Subject:

Diethylstilboestrol

Year

Page

COM consideration of

1993

38

Subject: Di-isopropylnaphthalenes in food packaging made from recycled paper and board:	Year	Page
Conclusion on mutagenicity studies using the mouse lymphoma assay (MLA)	2000	62
COT consideration of a JFSSG survey on DIPNs	1998	9
COT evaluation of new data since 1998 report	2000	14
COT updated evaluation	2002	9

Subject:

Dimethoate (insecticide)

Year

Page

COM consideration of

1992

39

Subject:

Dimethyldicarbonate (sterilising agent)

Year

Page

COM consideration of

1992

37

COT consideration of

1992

24

Subject:

Dimetridazole (anti-protozoal agent)

Year

Page

COM consideration of

2002

84

Subject:

2,4-Dinitrophenol

Year

Page

COT urgent advice on

2003

14

Subject: Dioxins	Year	Page
2,3,7,8-Tetrachlorodibenzo-p-Dioxin [TCDD], as a possible human carcinogen	1993	49
2,3,7,8-Tetrachlorodibenzo-P-Dioxin [TCDD]	1995	15, 64
Toxic Equivalency Factors for Dioxin Analogues Review of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin: Consideration of IARC Monograph Published in 1997	1998	19, 41
TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin)	1999	49
Carcinogenicity of	2001	136
Mixed halogenated	2010	14
Research on	2008	10
Toxic equivalency factors for dioxin analogues	1998	19

Subject: Dioxins and dioxin-like PCBs	Year	Page
In marine fish and fish products	1999	31
Consideration of the TDI	2001	7
Dioxins and dioxin-like PCBs	2000	26
Developmental effects in rats	2007	7, 30
Dietary exposure	2000	13
in free range eggs	2000	14
in fish oil – urgent advice	2002	9
2005 WHO Toxic Equivalency Factors	2006	15, 203
EFSA review of, comments on draft	2018	20
Follow up to EFSA reconsideration of,	2019	20
Dioxins - reanalysis by EPA	2012	10
Ongoing work	2020	33
Review of the 2018 EFSA opinion	2021	18

Subject:

Disinfectants and disinfection by-products

Year

Page

in prepared salads

2006

9, 61

Subject:

Dithiocarbamates

Year

Page

in latex products

1994

18

Subject:

DNA adduct inducing chemicals

Year

Page

Joint Meeting of COM and COC on the significance of low level exposures

1996

48

Subject:

DNA binding approaches

Year

Page

Target organ mutagenicity in carcinogen risk assessment – joint COC and COM meeting

2005

125

Subject:

DNA integrity

Year

Page

in human fertility investigations

2016

34

Subject:

DNA gyrase inhibitors

Year

Page

COC consideration of

1992

58

COM consideration of

1992

42

Subject:

DNA repair

Year

Page

at low doses, genotoxic carcinogens and, COM evaluation of

2004

136

COC evaluation of

176

Subject:

Dominant Lethal Assay

Year

Page

COM evaluation of

1994

26

Subject: Domoic acid	Year	Page
in King Scallops (Pecten Maximus)	2014	7

Subject:

Doramectin

Year

Page

in Lamb

2007

25

Subject:

Dose-response

Year

Page

Draft EFSA Scientific Committee Opinion on biological plausibility of non-monotonic dose responses and their impact on the risk assessment

2021

27

Subject: Drinking Water	Year	Page
Arsenic in,	1999	59
Benz(a)pyrene in,	1994	32
Boron in,	1994	35
Chlorinated	1991	32
Chlorinated drinking water, cancer and	2007	185
Chlorinated drinking water, cancer and	2008	278, 285
Chlorinated water, reproductive outcomes of,	1998	8
Fluoranthene in,	1994	34, 70
drinking water	1995	33
Trihalomethanes in drinking water, COM evaluation of	1994	22
Trihalomethanes in drinking water, COC evaluation of	1994	32

Subject: Drinks, plant-based	Year	Page
in the diet of children aged 1-5 (almond, soya, oat)	2019	19
in the diet of children aged 1-5 (almond, soya, oat)	2020	29
Statement on the consumption of plant-based drinks (almond, soya, oat)	2021	11
Working Group: COT/SACN Subgroup on plant-based drinks	2021	39

COT/COM/COC Annual Report Index

E - Index

In this guide

Subject:

ECETOC

Year

Page

Monograph on Aneuploidy

1997

78

workshop on use of T25 in chemical carcinogen evaluation

2001

141

Subject: Electronic nicotine, or non-nicotine, delivery s ystems (e-cigarettes), potential toxicological risks from	Year	Page
Aerosol particle fraction, characterisation of	2017	28
Carcinogenicity data, overview of available	2018	50
Exposure to EN(N)DS aerosols, metals and solvents, silicon/silicate particles, nicotine toxicity	2018	28
Exposure to EN(N)DS aerosols - known constituents and potential adverse health outcomes arising from	2020	9
Flavouring compounds, framework for risk assessment of	2019	18
Genotoxic risk, potential	2018	43
Nicotine salts in, a summary of data published to date	2020	34
Statement on,	2020	6
Toxicological risks, potential	2019	52
Addendum to the statement on	2021	26

Subject:

Endocrine disrupting chemicals

Year

Page

Definition for regulatory purposes

2010

11

Risk assessment of

2019

17

Subject:

Endosulfan

Year

Page

Endosulfan, pentachlorobenzene and chlordecone in the infant diet

2013

18

Subject:

Energy drinks

Year

Page

in the diet of children and adolescents, final statement on

2019

10

interim statement on

2018

29

Subject:

Enrofloxacin (veterinary medicine)

Year

Page

carcinogenicity in laboratory rodents

1993

50

in vitro and in vivo carcinogenicity

1992

56

Subject:

Environmental Tobacco Smoke (ETS) and lung cancer

Year

Page

COC statement on

1997

88

consideration of paper by Enstrom JE and Kabat GC (2003). British Medical Journal volume 326, 1057-1066

2003

191

Subject:

Environmental mutagens

Year

Page

Significance of environmental mutagenesis

2004

141

Subjects: Enzymes	Year	Page
Amano 90 – submission to COT	2000	15
Enzyme submission COT	2001	9
Chymosin – Enzyme submission COT	1999	16
Enzyme submission COT, modified recovery and purification	2000	16
Enzyme submission –derived from GM aspergillus niger var. awamori	2002	10
Enzyme submission –derived from GM Aspergillus niger var. awamori	2003	8
Hemicellulase Enzyme in bread-making	1999	19
Immobilised lipase from Rhizopus niveus COT consideration of the safety-in-use of	1994	9
COT consideration of additional data for	1998	13
Lipase D Enzyme submission COT	2000	16
Enzyme submission COT	2001	9
Newlase analytical method to detect rhizoxin	2000	17
Enzyme submission COT update, method review	2002	11
Enzyme submission COT,	2004	10
Enzyme Submission – Newlase analytical method to detect rhizoxin	2004	10
Xylanase preparation from Aspergillus niger	2001	13
Microbial enzyme preparations (safety assessment of)	1991	17

Subject:

Eosinophilia-myalgia syndrome, tryptophan and

Year

Page

risk to health of tryptophan, particularly in food supplements.

2003

21, 83

COT review of a contaminant in the tryptophan produced by one manufacturer

2004

12

Subject: Epigenetics in carcinogenesis	Year	Page
COC evaluation of	2013	53
COC evaluation of	2016	35
in chemical risk assessment,	2017	54
in chemical risk assessment,	2017	43
joint committee workshop on	2018	42

Subject:

Epoxidised soya bean oil

Year

Page

COT evaluation of; TDI

1994

8

COT evaluation of; updated guidance from 1994 report

1999

16

Subject:

Erythritol

Year

Page

laxation

2003

9

sensitivity of young children to polyols

2004

9

Subject:

Erythrosine

Year

Page

COT review of

1991

29

Subject:

Ethaboxam

Year

Page

partial COM review of

2007

131

Subject:

Ethanol (see also alcohol)

Year

Page

acetaldehyde and alcoholic beverages

2000

62

effects on pregnancy, reproduction and infant

development

1995

8

Subject:

Exhaust, diesel

Year

Page

Carcinogenicity of

1991

47

Subject: Exposure Assessment	Year	Page
Food chemicals, to	2002	12
Less than lifetime	2020	31
Statement on assessment of less than lifetime exposure	2021	19
single or short term, to carcinogens	2005	140
Draft EFSA Scientific Committee Opinion on scientific criteria for grouping chemicals into assessment groups for human risk assessment of combined exposure to multiple chemicals	2021	26

COT/COM/COC Annual Report Index

F - Index

In this guide

Subject:

Florfenicol (veterinary medicine)

Year

Page

COT review of,

1993

12

Subject: Fluoride/fluorine	Year	Page
COT evaluation, Expert Group on Vitamins and Minerals	2001	23
COT evaluation, Expert Group on Vitamins and Minerals	2002	19
Mutagenicity of	1995	35

Subject:

Fluorine, bromine and iodine

Year

Page

COT evaluation using 1997 Total Diet Study

2000

17

Subject:

Fluoranthene in drinking water

Year

Page

Mutagenicity and carcinogenicity of

1994

34, 70

Mutagenicity studies, in-vivo

1995

33

Subject:

Fluorosis, dental

Year

Page

COT discussion of,

2003

9

Subject:

Flunixin, meglumine and flunixin-meglumine

Year

Page

Mutagenicity of

2003

129

Mutagenicity of

2005

119

Subject: Folic acid	Year	Page
COC evaluation of,	2009	71
Colorectal cancer risk and fortification COC discussion of	2006	282
Updated COC evaluation	2007	181
Tolerable Upper Level of folic acid, COT review of	2018	28
Tolerable Upper Level, COT statement on	2019	7

Subject:

Food Colours

Year

Page

and children’s behaviour, research

2007

8

Subject: Food Surveillance Papers	Year	Page
COT consideration of three Working Party reports	1991	22
Working party reports considered – pesticide residues, mycotoxins, aluminium	1992	27
Miscellaneous naturally occurring toxicants in food,	1993	23,
Fumonisins	1993	48

Subject: Food additives	Year	Page
Behaviour and,	2002	11
Developmental toxicology and,	2005	5, 42
Hyperactivity and,	2000	27

Subject:

Food and food ingredients

Year

Page

adverse reactions to,

2000

10

Subject:

Food and drug interactions

Year

Page

Joint meeting with the Committee on Safety of Medicines on

food-drug interactions

2004

23

Joint COT/CSM one day meeting on diet and drug

interactions

2005

27

Subject:

Food Intolerance

Year

Page

Working group update

1997

17

first draft report

1999

16

Subject: Food Standards Agency funded research and surveys	Year	Page
Aneugenic benzimidazoles, other aneugens and other substances in the in vitro micronucleus assay, combined effects of	2013	42
COT discussion of,	2000	18
Health effects of mixtures of food additives (T01040/41)	2008	10, 204
Interpretation of Margins of Exposure for Genotoxic Carcinogens (T01051)	2013	56
Mixtures of pesticides and similar substances	2011	11
Soya phytoestrogens in patients with compensated hypogonadism	2014	10
Soya isoflavones on markers of bone turnover in females in the early menopause	2014	10
Soya phytoestrogen supplementation on thyroid status and cardiovascular risk	2014	11

Subject:

Formaldehyde

Year

Page

COC discussion of,

2007

182

Systemic mutagenicity, evidence for

2007

133

Subject: French Maritime Pine bark extract	Year	Page
COT evaluation of, in vitro and in vivo toxicity	1998	10
Updated COT evaluation of	1999	16
Updated COT evaluation, allergen detection	2000	19

Subject:

Fumagillin (veterinary medicine)

Year

Page

Fumagillin Dicyclohexylamine, evaluation of

2011

41

Mutagenicity testing strategy for

2009

49

Subject:

Fumonisins

Year

Page

carcinogenic hazard, surveillance programmes

1993

48

in maize meal

2003

15

Subject: Furan	Year	Page
COC evaluation of	2005	135
COM evaluation of	2005	84
COT evaluation of	2005	8

Subject:

Furocoumarins in the diet

Year

Page

COC evaluation of

1994

39

COM evaluation of

1994

25

COT/COM/COC Annual Report Index

G - Index

In this guide

Subject:

GADD45a GFP ‘Green Screen’ assay

Year

Page

COM Discussion of

2010

42

Subject:

Gallates (anti-oxidants in food)

Year

Page

COM Discussion of

1992

37

Subject:

Gellan gum

Year

Page

COT Evaluation of

1993

13

Subject:

Genetically modified

Year

Page

Potatoes genetically modified to produce Galanthus nivalis

Lectin

1999

34

Subject: Genetic susceptibility to cancer	Year	Page
COC/COM Joint Symposium on	1998	33
Joint COC/COM symposium on genetic susceptibility to cancer	1998	35
COC scoping discussion on,	2000	110

Subject:

Genomics and proteomics in toxicology, Joint meeting of COT/COC/COM on

Year

Page

assessing their current and future potential as tools in regulatory risk assessments.

2001

24, 109,

143

use of genomics and proteomics in toxicology

2002

14

Subject:

Genotoxic Consequences of Exposure to Mixtures of Food Derived Chemical Carcinogens

Year

Page

COM review of FSA funded research on

2012

39

Subject:

Genotoxic alkylating agents

Year

Page

Thresholds for

2006

237

Subject: Genotoxic carcinogens	Year	Page
and DNA repair at low doses	2004	136, 176
Acute T25 – possible approach to potency ranking of single exposure	2006	279
The occurrence of “U” shaped dose dose-response curves	2003	196
European Food Safety Authority (EFSA) Advice to- chemicals that are genotoxic and carcinogenic	2005	141
Genotoxicity Testing of Impurities	2011	44
Interim Guidance on a Strategy for Genotoxicity Testing and Assessment of Impurities	2012	35

Subject:

Genotoxicity data

Year

Page

Interpretation of, two-day 2019 workshop on

2020

48

Subject:

Genotoxicity, evidence for

Year

Page

Genotoxicity testing and mutagenic hazard assessment of chemical substances. Consultation on a strategy for

2010

48

consolidated summary of discussions

2017

42

Subject:

Genotoxicity of Nanomaterials

Year

Page

A COM statement is currently being drafted

2011

45

in vitro genotoxicity testing of nanomaterials

2012

36

Subject:

Genotoxicity of water and wastewater

Year

Page

ISO Water quality standard: Determination of the genotoxicity of water and waste water using the umu test

1997

69

Subject: Genotype and environment interaction on susceptibility to cancer	Year	Page
COC review of	2001	121
The investigation of interaction between genotype and chemicals in the environment on the induction of cancer	2002	132
Genotypes and chemicals in the environment on the induction of cancer in risk assessment. Interaction between	2010	59

Subject: Germ cell mutagenesis	Year	Page
investigating germ cell mutagenesis, the germ cell genome, meiosis and mutagenesis, the paternal age effect and aneuploidy in germ cells	2015	38
adverse outcome pathways	2016	34
consolidated summary of discussions	2017	43
Strategy for investigating germ cell mutagens	2003	138
Germ cell mutagens, COM guidance on testing	2021	53

Subject:

Ginger

Year

Page

ongoing work on the COT contribution to the SACN risk assessment on nutrition and, ginger

2021

33

Subject:

Glucosamine and hepatotoxicity

Year

Page

a very small number of individual case reports linking glucosamine and hepatitis

2008

20

case reports linking glucosamine and hepatitis

2009

15, 38

Subject:

Gluten – timing of introduction into the infant diet

Year

Page

and subsequent risk of developing coeliac disease or type 1 diabetes mellitus (T1DM)

2010

27

Further discussions on subsequent risk of developing coeliac disease or type 1 diabetes mellitus (T1DM)

2011

11

Subject:

Guidance statement on the human health significance of chemical induced mutagenicity

Year

Page

joint COC, COM and COT workshop on ‘Whether epigenetics should be used in chemical risk assessment’

2017

55

information on chemically induced mutagenesis relevant to human health to the informed lay reader.

2013

45, 59

Subject: Guidance statements, COC	Year	Page
Mode of Action, Human Relevance Framework and Margin of Exposure	2011	58
overarching statement G1, a statement on risk characterisation methods for carcinogens	2012	48
Overarching strategy (GO1)	2019	53
Guidance statement update	2020	65
Guidance statement update on the use of biomarkers in carcinogenic risk assessment (G04)	2018	52
Hazard identification and characterisation: conduct and interpretation of animal carcinogenicity studies (G03), update of	2021	80
Guidance statement update	2018	52
Defining a point of departure and potency estimates in carcinogenic dose response (G05)	2018	52
Guidance statement update	2018	52
Further discussion papers on	2019	53
Risk characterisation methods (G06)	2018	52
Risk characterisation methods (G06) update of	2021	80
Alternatives to the 2-year bioassay (G07)	2018	52
Combined exposure to chemical carcinogens (GO8)	2019	54
Less than lifetime exposure (GO9)	2019	54

Subject: Guidance statements, COM	Year	Page
Guidance on use of (Q)SAR models to predict genotoxicity, evaluation of in vivo genotoxicity	2018	40
Guidance on Mutagenic Hazard Assessment and a Strategy for Genotoxicity Testing of Chemicals with Inadequate Genotoxicity Data	2011	43
Guidance on the use of (Q)SAR models to predict genotoxicity	2018	40
Guidance series, COM update of	2019	34
Guidance series, COM update of	2020	47
Guidance series, COM update of	2021	53
Guidance on assessment strategies and genotoxicity tests	2010	41
ICH guidelines: Genotoxicity: A standard battery for genotoxicity testing of pharmaceuticals (S2B) and consideration of the mouse lymphoma assay	1997	75
Germ cell mutagens, guidance on	2021	53
3D models, guidance on	2021	53
Testing strategies for nanomaterials, guidance on	2021	54
Testing strategies for impurities, update on guidance	2021	54
Use of QSAR models, guidance on	2021	54

Subject:

Gut microbiome

Year

Page

effects of xenobiotics on

2019

15

statement on the effect of xenobiotics on the gut microbiome and the effect the gut microbiome on xenobiotics with reference to chemical risk assessment

2020

11

COT/COM/COC Annual Report Index

H - Index

In this guide

Subject:

Health and Safety Executive (HSE)

Year

Page

Work of, presentation to COM on

2021

63

Subject: Health effects in populations living close to landfill sites	Year	Page
Negative birth outcomes and cancer	2000	19
Landfill sites	2001	11
COT statement on, consideration of SAHSU study	2001	12

Subject:

Heat-not-burn tobacco products and their safety overview of genotoxicity data submitted (confidential)

Year

Page

Assessment of the toxicological risks from novel heat-not-burn tobacco products

2017

8, 51

Kl’Assessment of the toxicological risks from novel heat-not-burn tobacco products

2017

41

Subject: Hemicellulase	Year	Page
Hemicellulase Enzyme in bread-making	1999	19
From Aspergillus niger	1994	8
Hemicellulase, preparations of	1995	9
Hemicellulase	1996	9

Subject:

Hexachlorobutadiene contamination at Weston Quarries

Year

Page

In Cheshire, mutagenicity

2000

20

Hexachlorobutadiene, new data considerations

2003

10

Subject: Hexabromocyclododecanes in the infant diet	Year	Page
possible health risks from the exposure of infants to HBCDDs in breast milk, dust and food	2014	12
Estimated exposures, margin of exposure	2015	7
and young children	2016	11kl

Subject:

Hexachlorocyclohexanes in the infant diet

Year

Page

α-, β- and γ-hexachlorocyclohexanes

2003

10

Subject:

Histamine

Year

Page

In food

2016

12

Subject:

Hormesis

Year

Page

The occurrence of “U” shaped dose dose-response curves

2003

196

in Mutagenicity Dose-Response Relationships

2012

38

Subject:

Hydrocarbon propellants

Year

Page

Safety of

1994

9

Subject: Hydroquinone and phenol	Year	Page
interpretation of the mutagenicity data on	1994	20
metabolism of hydroquinone and phenolic derivatives in the lung and skin	1995	34
COM re-evaluation, inhalation and dermal exposure	2000	60
review of mutagenicity of Aclonifen and risk assessments of its postulated metabolites	2008	262

Subject:

Hydroxyanthracene derivatives (HADs)

Year

Page

COM evaluation of

2021

62

Subject:

Hyperactivity

Year

Page

Hyperactive children’s support group

1996

9

Hyperactivity and food additives

2000

27

COT/COM/COC Annual Report Index

I - Index

In this guide

Subject: Idiopathic Environmental Intolerance: Evidence for a toxicological mechanism	Year	Page
and psychological aspects of IEI	2010	27
reviewed the published scientific literature on	2011	13
Idiopathic Environmental Intolerance: Evidence for a toxicological mechanism	2009	36

Subject: IGHRC	Year	Page
paper on uncertainty factors	2001	13
paper on uncertainty factors	2002	129
Guidance document on chemical mixtures	2007	21
Guidelines on route-to-route extrapolation of toxicity data when assessing health risks of chemicals	2005	15

Subject: IGF-1: Possible carcinogenic hazard to consumers IGF-1 and cancer risk	Year	Page
dietary absorption, levels of IGF-1in food and the association between blood levels of IGF1 and the risk of certain types of cancer.	2012	47
dietary absorption, levels of IGF-1 in food and the association between blood levels of IGF1 and the risk of certain types of cancer. The review is ongoing, though it was not possible to progress work on it in 2013.	2013	58
dietary absorption, levels of IGF-1 in food and the association between blood levels of IGF-1 and the risk of certain types of cancer.	2017	55
Insulin-like growth factor-1 (IGF-1) in the diet, The potential carcinogenic risk of	2009	229

Subject:

ILSI/HESI

Year

Page

ILSI/HESI research programme on alternative cancer models: results of Syrian hamster embryo cell transformation assay

2002

87

ILSI/HESI workshop on less-than-lifetime exposure to carcinogens

2012

44

Subject:

Imidocarb (antiparasitic drug used to treat babesiosis in cattle)

Year

Page

Safety of,

1992

38, 57

Subject: Impurities	Year	Page
determining, testing, controlling specific impurities in pharmaceuticals that possess potential for genotoxicity.	2008	227
Genotoxicity Testing of Impurities	2011	44
in the pesticide 1-methylcyclopropene	2003	191
Interim Guidance on a Strategy for Genotoxicity Testing and Assessment of Impurities	2012	35
Testing strategies for impurities, COM update on guidance	2021	54

Subject:

Immunomodulation in cancer development

Year

Page

Immunological and stromal cell modulations relevant to cancer, presentation to COC

2018

50

Subject:

Intrahepatic cholangiocarcinoma

Year

Page

Increase in mortality rates from intrahepatic cholangiocarcinoma in England and Wales 1968-1998

2001

138

Intrahepatic cholangiocarcinoma

2003

192

Subject: In the diet of infants and children	Year	Page
contaminants in- overarching statement.	2019	8
Hydrolysed cows’ milk formulae: role in influencing the development of atopic outcomes and autoimmune disease	2016	14
Statement on the potential risk from chemicals in the diet of infants aged 0 to 12 months and children aged 1 to 5 years.	2020	9
Health assessment of the exposure of 2 year-olds to chemical substances in consumer products’ Danish Environmental Protection Agency (EPA) report on	2010	8
Infant feeding and allergy	2013	30
Infant food, metals and other elements in	1999	27
Iodine in the diet of infants and young children	2017	7
Long chain polyunsaturated fatty acid for use in infant formula	1997	19
Methylmercury in the diets of infants and young children	2018	8
Neosolaniol, T2-toxin and HT2-toxin in the diet of infants aged 0-1 and young children aged 1-5 years.	2018	15
Effect of certain food colours and a preservative on behaviour in children research project results	2007	8
Oat drinks in the diet of infants aged 1-5	2019	19
Oat drinks in the diet of infants aged 1-5	2020	29
Endosulfan, pentachlorobenzene and chlordecone in the infant diet	2013	18
Phthalates in infant formulae	1996	10
Phytoestrogens in soya-based infant formulae	1998	17,18
Phytoestrogens in soya-based infant formulas	1999	35
Polybrominated biphenyls (PBBs) in diet of infants	2015	9
Polybrominated biphenyls (PBBs) in diet of infants and 1 – 5 year old children	2015	10
Soya drinks, in the diet of infants aged 1-5	2019	19
Soya drinks, in the diet of infants aged 1-5	2020	29
T2-toxin and HT2-toxin and neosolaniol in the diet of infants aged 0-1 and young children aged 1-5 years.	2018	15

Subject: *In vitro* micronucleus test	Year	Page
COM considered the progress in the development of the	1994	26
European Environmental Mutagenicity Society (EEMS)	1996	47
COM advice and evaluation of	2004	144
(IWGT meeting)	2002	88

Subject: *In vivo assays*	Year	Page
In vivo gene mutation assays using transgenic animal mode models	1996	45
In-vivo mutagenicity at high doses, Significance of	2002	89
In vivo PIG-A mutagenicity assay	2010	44

Subject: Iodine	Year	Page
Toxicity in adults and young children	1992	25
Fluorine and bromine, 1997 Total Diet Study	2000	17
in cows’ milk	Year	Page
Iodine	1997	17
Iodine	1999	20
Iodine	2002	20
Iodine	2003	10
in diet of infants and young children	2017	7
Potential effects of excess iodine intake during preconception, pregnancy and lactation, statement on	2020	19
ongoing work on the COT contribution to the SACN risk assessment on nutrition and,	2021	34

Subject:

Iron

Year

Page

Iron, Toxicological aspects of the SACN report on

2009

29

report on Iron and Health,

2009

75

Subject: Irritant Sprays	Year	Page
Irritant sprays	2016	14
Guidance on submission of papers to COT regarding irritant sprays and information required	Year	Page
Guidance to applicants on the type of information that should be supplied to enable the Committee to develop an opinion about the safety of the formulation.	2017	28
Home Office Centre for Applied Science and Technology (now Dstl) requests review of the safety of these from the COT.	2018	16

COT/COM/COC Annual Report Index

J - Index

In this guide

COT/COM/COC Annual Report Index

K - Index

In this guide

Subject:

Kava kava (herb)

Year

Page

urgent advice

2002

14

in food products

2005

9

COT/COM/COC Annual Report Index

L - Index

In this guide

Subject:

Lactic acid producing cultures

Year

Page

Lactic acid producing cultures

1991

14

Subject: Landfill sites	Year	Page
Review of studies from 2007 to 2009	2010	13
and congenital anomalies	1998	13
and adverse birth outcomes	2007	24
Chemical exposure resulting from	2009	36
Potential exposure to substances from	2008	20
landfill sites, negative birth outcomes and cancer	2000	19
Health effects of populations living close to,	2001	11
COT statement on, consideration of SAHSU study	2001	12

Subject: Lead in the infant diet	Year	Page
Exposure, uncertainty, toxicity	2013	19
addendum to its 2013 statement	2016	14
Lead ammunition group final report	2015	8

Subject:

Leukaemia

Year

Page

Advice on three paediatric cases in Camelford, North Cornwall

1996

57

and drinking water in Southwest England

1997

105

Subject:

Lindane (Insecticide)

Year

Page

Mutagenicity of,

1995

33

Subject: Lowermoor subgroup	Year	Page
The Lowermoor subgroup held six further meetings in 2004. A draft report will be published for consultation in January 2005.	2004	15
COT review of draft report	2005	14
delayed or persistent harm to health, monitoring and research	2006	18
Updated COT evaluation of	2007	23
COT update, delayed publication	2008	19
Inquest postponement, subgroup postponement	2009	35
Contaminated water, final subgroup	2010	25
Final COT report on	2012	20

Subject:

Lupins

Year

Page

Safety evaluation of,

1995

10

COT/COM/COC Annual Report Index

M - Index

In this guide

Subject: Malachite Green	Year	Page
In farmed trout, voluntary sampling programme	1993	14
Update on sampling and 1993 report	1995	12
COM evaluation, including Leucomalachite green	1999	47
mutagenicity of	2003	130
and Leucomalachite Green	2004	138, 152, 182
in Farmed fish	1999	23

Subject:

Malathion (insecticide)

Year

Page

COM and COC evaluation of use in insecticides and human medicinal use, in vivo studies in rats and mice

2002

84, 126

in-vivo oral rat liver UDS assay

2003

132

Subject: Male reproductive system	Year	Page
Adverse trends in the development of	2003	21
Adverse trends in the development of the male reproductive system	2004	7, 32
Development and function in adulthood of the male reproductive system:	2006	8, 47

Subject: Man-made mineral fibres	Year	Page
(MMMFS: Glass Fibres, Rock and Slag Wool, but not Refractory Ceramic Fibres)	1994	38
(MMMFs: Glass fibres, rock and Slag wool excluding Refractory Ceramic Fibres)	1996	65
Refractory ceramic fibres	1995	68

Subject:

Manganese in the infant diet

Year

Page

Lay summary, discussion paper and draft statement had not yet been placed in the public domain

2018

27

a range of effects on the nervous system

2019

11

Subject:

Marine biotoxins

Year

Page

discussion on the risk assessment and monitoring of

2005

17

Risk assessment of Okadaic acid, Pectenotoxin, Azaspiracid, Yessotoxin

2006

13, 156

Subject: Maternal health	Year	Page
ongoing work on the COT contribution to the SACN risk assessment on nutrition and	2020	32
ongoing work on the COT contribution to the SACN risk assessment on nutrition and, prioritisation of xenobiotics	2021	30
ongoing work on the COT contribution to the SACN risk assessment on nutrition and, alcohol; 2016 Chief Medical Officers Report	2021	31
ongoing work on the COT contribution to the SACN risk assessment on nutrition and, vitamin D	2021	31
ongoing work on the COT contribution to the SACN risk assessment on nutrition and, cadmium	2021	31
ongoing work on the COT contribution to the SACN risk assessment on nutrition and, vitamin A	2021	33
ongoing work on the COT contribution to the SACN risk assessment on nutrition and, ginger	2021	33
ongoing work on the COT contribution to the SACN risk assessment on nutrition and, iodine	2021	34
Hypospadias and maternal nutrition	1999	19
Maternal and infant dietary exposures and risk of development of atopic outcomes and autoimmune disease.	2017	26

Subject:

Mathematical modelling

Year

Page

Applications in toxicology

1999

27

Subject:

Meglumine

Year

Page

Flunixin, meglumine and Flunixin-megulimine

2003

129

mutagenicity of

2005

87, 119

Subject:

Mercury in fish and shellfish

Year

Page

Survey of; neurotoxicity in foetuses and neonates

2002

17

reconsideration of 2002 COT opinion

2003

12

Subject: Metals and other elements	Year	Page
in infant food	1999	27
in infant foods	2003	12
in infant foods, Survey of	2017	27
Statement on the results of the 2014 survey of	2018	11
in the 2000 Total Diet Study	2003	12
Biological effects of wear debris generated from metal on metal on metal bearing surfaces	2006	232, 241
2006 UK Total Diet Study	2008	16, 170

Subject:

Methanol

Year

Page

Methanol – chronic toxicity

2010

28

Effects of chronic dietary exposure to methanol

2011

10

Subject:

Methylation

Year

Page

transgenerational effects of

2006

236

Subject:

Methylcyclopentadienyl manganese tricarbonyl

Year

Page

Petrol additive

1999

29

Subject:

1- Methylcyclopropene (plant growth regulator)

Year

Page

Impurities in

2003

191

Subject:

Methylgloxal

Year

Page

Methylglyoxal

2009

16, 76

Subject:

Microbiome

Year

Page

COC evaluation of

2020

62

Subject:

Microenvironment

Year

Page

Of tumours

2020

63

Subject: Microplastics	Year	Page
Review of,	2019	16
Statement on the potential risks of exposure from microplastics	2020	13
Overarching statement on the potential risks of exposure from microplastics	2021	9
Sub-statement on the potential risks of exposure from microplastics: oral route	2021	10

Subject:

Milk

Year

Page

Persistent environmental chemicals in human

2009

223

Risk assessment of potential constituents and contaminants in cow’s milk

2021

37

Subject:

Mineral hydrocarbons

Year

Page

In food, COT conclusions

1993

15

Subject: Mixtures	Year	Page
Chemical	2008	229, 236
an appraisal of a report on “State of the Art on Mixture Toxicity”	2010	15
Carcinogenicity of	2008	284
Carcinogenicity of	2010	57
IGHRC guidance document	2007	21

Subject:

3-Monochloro-propane 1,2-diol (3-MCPD)

Year

Page

COM evaluation of, in vitro and in vivo toxicity

1999

48

Drinking water, food and ingredients, COM and COC updated in vitro and in vivo toxicity

2000

61, 102

Subject: Mouse assay	Year	Page
Mouse lymphoma assay, Presentation by Dr Jane Cole	1997	77
Mouse bioassay, atypical results in the lipophilic shellfish toxin mouse bioassay	2004	8
Mouse carcinogenicity bioassay	1997	70, 117
Mouse Spot Test	1992	44

Subject:

Multi-element survey

Year

Page

in various items in the diet

1998

15

of wild fungi and blackberries

1999

28

Subject: Multiple Chemical Sensitivity	Year	Page
In patients, COT evaluation	1999	30
In patients, COT evaluation update	2000	21
Multi-strain assays	2009	16

Subject: Municipal solid waste incinerators in Great Britain, Cancer incidence near	Year	Page
COC evaluation of over 14 million people living near to 72 MWIs, liver cancer	2000	104
Update review of epidemiological studies	2008	284
considered three further papers on this topic published since the 2009 review	2011	54

Subject: Mutagenicity	Year	Page
Comet assay	2006	239, 249
UDS assay	2006	239, 249
Halonitromethanes (HNMs)	2005	85, 116
Historical control data in mutagenicity studies	1996	47
Mutagenicity	2012	36
Joint symposium with COM on use of target organ mutagenicity in carcinogen risk assessment	2004	192
Joint meeting of COT/COM on use of target organ mutagenicity assays in carcinogen risk assessment	2005	92, 124
Review of current approaches to germ cell mutagenicity testing	2013	45
Significance of environmental mutagenesis	2004	141
Significance of in vivo mutagenicity at high doses	2003	139
Organ mutagencity data in carcinogen risk assessment	2005	124

Subject: Mutagenicity testing strategies	Year	Page
for new substances	1991	33
on New Substances: Further Advice to HSE	1992	43
In vitro mammalian cell mutation assays	2003	137
Review of current approaches to germ cell mutagenicity testing	2013	45
‘Risk assessment methodologies and approaches for mutagenic and carcinogenic substances’, Preliminary Report by the EU Scientific Committees on Consumer Products, on Health and Environmental Risks, and on Emerging and Newly-Identified Risks on	2008	280

Subject: Mutagens	Year	Page
classifications of	1992	43
Thresholds for in vivo	2010	41
Classification of chemicals on the basis of mutagenic properties	1992	43
International workshop on the categorisation of mutagens	2001	108
Mutational spectra	2014	35
signatures of environmental mutagens, presentation on mutational spectra and,	2020	48
Mutational signatures associated with tobacco smoking in human cancer- and associated editorial paper	2017	53
Muta®mouse and Big Blue transgenic rodent assay systems	2005	12434
Risk assessment of in vivo mutagens (and genotoxic mutagens)	2001	107

Subject:

Mutational spectra

Year

Page

Statement on the use of mutation spectra in genetic

toxicology

2015

35

Mutational spectra

1999

51, 72

Subject: Mycotoxins	Year	Page
Prioritization of micro-components of the diet for further toxicity testing or surveillance	1991	31, 48
In cheese	2006	9
Statement on the potential risks of combined exposure to mycotoxins	2020	18
Statement on the potential risks of combined exposure to mycotoxins	2021	7
Moniliformin in maize and maize products	1998	14

COT/COM/COC Annual Report Index

N - Index

In this guide

Subject: Nanomaterial toxicology	Year	Page
joint COT/COC/COM statement	2005	16, 65
Joint COT/COC/COM review of nanomaterials	2005	86
in healthcare	2006	19
Joint statement of COC/COM/COT, COT addendum	2007	27
Nanomaterial review	2005	86
Nanoparticles used in healthcare and update on nanomaterial technology	2007	9
Nanotechnologies in the food and feed area	2008	11
Royal society study on nanoscience and nanotechnology	2004	20
Testing strategies for nanomaterials, guidance on	2021	54

Subject:

Natural toxins

Year

Page

Possible regulation of

1992

44, 59

Subject:

New Approach Methodologies (NAMs)

Year

Page

NAMs Roadmap

2021

35

Subject: Newlase	Year	Page
Enzyme submission COT, revised method to detect rhizoxin	2000	17
Enzyme submission COT, revised method to detect rhizoxin	2002	11
Enzyme submission COT, Newlase was granted full clearance for detection of rhizoxin	2004	10

Subject:

Neurotoxicity

Year

Page

Developmental

2009

14

Subject: Nickel	Year	Page
COT evaluation of	2003	13
domestic kettle usage patterns	2006	19
Statement on potential risks from nickel	2018	12

Subject:

Nicotine

Year

Page

Nicotine from nicotine patches, Possible nitration of

2002

86

Nicotine salts, summary of data published to date on the presence and pharmacokinetics of in electronic nicotine delivery systems (ENDS) products

2020

34

Subject:

Nitrate

Year

Page

metabolism in man

1998

16

Subject:

Nitrous oxide

Year

Page

Nitrous oxide

1995

14

Subject:

Nitrosamines

Year

Page

potency ranking in tobacco smoke

1995

71

Subject:

N-nitroso compounds

Year

Page

Dose-response relationship in rats

1992

59

Subject:

Non genotoxic carcinogens

Year

Page

Integrated Approach to Testing and Assessment (IATA) on Non-genotoxic carcinogens, update on OECD activity

2019

51

Early identification of

2000

106

Subject: Non-Hodgkin’s lymphoma	Year	Page
and Occupational Exposure to Certain Pesticides	1993	51
Review of epidemiological studies have been carried out on the association between chemicals and	2007	185
and exposure to environmental chemicals, including pesticides, organic solvents, 71 industrial chemicals, and chemicals associated with lifestyle.	2009	70
Chemical aetiology	2008	284

Subject: Nonivamide (PAVA)	Year	Page
as a chemical incapacitant	2001	25
as an incapacitant spray	2002	18, 85
Reformulation of	2007	10
PAVA irritant spray	2017	28
consideration of an updated statement in the light of new evidence	2004	11, 107

Subject: Nonivamide (PAVA) and 2-Chlorobenzylidene malontrile (CS): combined use	Year	Page
Potential effects of exposure	2005	17
Potential effects of exposure	2006	7, 21
reformulation of both PAVA and CS using a new non-flammable solvent.	2015	8
CS – Sabre 540010-01 ; TW1000, a new formulation of PAVA	2018	16
CS as an irritant spray	2017	28

Subject: Novel fat	Year	Page
for use in confectionery	1992	18
Novel oils for use in infant formulae	1995	14
Olestra	1993	35

Subject:

Nuclear establishments

Year

Page

Chemicals used at

1991

35

Paternal exposure to chemicals, possibility of paternal exposure inducing cancer in offspring

1991

36

COT/COM/COC Annual Report Index

O - Index

In this guide

Subject: Oat drinks	Year	Page
in the diet of infants aged 1-5	2019	19
in the diet of infants aged 1-5	2020	29
Statement on the consumption of plant-based drinks (almond, soya, oat)	2021	11

Subject:

Obesogen hypothesis

Year

Page

Obesogen hypothesis

2013

21

Subject:

Ochratoxin A

Year

Page

COT evaluation of ochratoxin A concentrations in foodstuffs purchased in the UK in 1997

1997

20

Statement on potential risks from ochratoxin A (OTA)

2018

14

Subject: OECD genotoxicity test guidelines update	Year	Page
Revisions to OECD Genetic Toxicology Test Guidelines.	2015	43
The committee kept up to date with discussions at OECD with regard to genotoxicity test guidelines.	2017	43
in vitro mammalian cell micronucleus assay, in vivo transgenic rodent gene mutation assay, 3D reconstructed skin micronucleus assay, validation of the Pig-A assay	2019	40
Pig-A assay, update on	2020	52
OECD Guidance document for the performance of chronic toxicity and carcinogenicity studies	2009	225
OECD Test Guidelines for carcinogenicity studies, Revision of	2008	282
OECD guidelines; ToxTracker assay, Standard Project Submission form for,	2017	51
OECD Development of mini Ames test, presentation on	2021	59
OECD Development of mini Ames test, guidance on	2021	64

Subject:

Ohmic heating

Year

Page

A novel foods sterilisation process

1991

19

Subject:

Olfactory neuroblastomas: possible association in dentists and dental nurses

Year

Page

Ongoing COC review of

2003

197

COT statement on

2004

179, 251

Subject: Omethoate (insecticide)	Year	Page
Mutagenicity of,	1992	38
Subject: Openness (see also Committee procedures)	Year	Page
Publication of the minutes and Committee papers	1999	30
Proposal to hold meetings in open session	2002	20
Further discussions on Openness of Committee Business	2003	194

Subject: Organochlorines and breast cancer	Year	Page
Insecticides (OCIs)	1995	66
Insecticides (OCIs)	1999	62
Insecticides (OCIs)	2003	196
Insecticides (OCIs)	2004	180

Subject: Organophosphates	Year	Page
COT evaluation, neurophysiological effects and peripheral neuropathy	1999	30
exposure in horticultural workers, genotoxic effects of	2010	40
and human health	2007	10
and human health: outstanding Government funded research	2009	18
Long-term neurological, neuropsychological and psychiatric effects of low-level exposure to organophosphates in adults	2014	13
Organophosphorus esters	1998	17

Subject: OST code of practice for scientific advisory committees and committee procedures in light of the Government’s response to the BSE enquiry report	Year	Page
second round of consultation	2001	14, 139
COM review of	2002	86, 129
Procedure for holding COT meetings in open session	2003	17

Subject:

Ozone

Year

Page

Carcinogenicity and mutagenicity of,

1999

50

review of animal carcinogenicity data

1999

71

COT/COM/COC Annual Report Index

P - Index

In this guide

Subject:

p-53 tumour suppressor gene

Year

Page

Joint COC/COM Symposium,

1993

39

Subject:

Parachloroaniline

Year

Page

COM evaluation of the available genotoxicity data

2009

52

Review of the genotoxicity data for

2018

43

Subject:

Polycyclic Aromatic Hydrocarbons (PAH)

Year

Page

PAH concentrations in food: interim pragmatic guideline limits for use in emergencies

2001

14

PAHs in shellfish

2001

14

Subject:

Plastic Packaging

Year

Page

Alternatives to,

2020

30

Subject:

Paraffins in food

Year

Page

Chlorinated,

2009

13, 111

Subject:

Paralytic Shellfish Poisoning (PSP)

Year

Page

Measurement of toxins that cause,

2011

15

biotoxins

2010

18

Subject: Paraoccupational exposure to pesticides	Year	Page
and health outcomes other than cancer	2011	16
Systematic review of the epidemiological literature on,	2010	62
and health outcomes	2009	36
Systematic review of the epidemiological literature on	2010	28

Subject:

Para red

Year

Page

Mutagenicity of

2005

12

risk assessment

2005

72

Subject:

Passive smoking

Year

Page

Health effects of,

1993

52

Subject:

Pathway Analysis Software

Year

Page

for the interpretation of complex datasets

2009

26

Subject:

Patulin

Year

Page

Mutagenicity and carcinogenicity of,

1991

49

Review of genotoxicity of,

2019

37

Subject: PAVA (Nonivamide)	Year	Page
use as an incapacitant spray	2004	95
as a chemical incapacitant	2001	25
as an incapacitant spray	2002	18, 85
reformulation of	2006	19
Reformulation of	2007	10
Combined use of CS (2-chloro-benzylidene malonitrile) and PAVA (nonivamide) (captor 2) irritant sprays	2013	14
and 2-chlorobenzylidene malononitrile (CS) formulation as irritant sprays	2015	8
consideration of an updated statement in light of new evidence	2004	11, 107
PAVA (Nonivamide) and 2-chlorobenzlidene malonitrile: combined use	2005	17
PAVA (Nonivamide) and 2-chlorobenzlidene malonitrile: combined use	2006	7, 21
PAVA (Nonivamide) and 2-chlorobenzlidene malonitrile: combined use	2013	14
reformulation of both PAVA and CS using a new non-flammable solvent.	2015	8

Subject:

Polychlorinated biphenyls (PCBs)

Year

Page

PCBs in breast milk

2001

19

Subject: Peanut allergy	Year	Page
Working Group	1996	10
association between early exposure to peanuts and peanut products and the incidence of peanut allergy later in life	1997	23
In early life, consumption of peanuts and peanut products by pregnant and lactating women, infants and young children.	1998	18
Peanut avoidance review of the 1998 COT recommendations on	2008	12, 133

Subject:

Pediatric leukaemia

Year

Page

cases in Camelford, North Cornwall

1996

57

Subject:

People for the Ethical Treatment of Animals (PETA)

Year

Page

“Creative Accounting” Report by

2006

282

Subject: Perfluorooctanoic acid (PFOA)	Year	Page
Mutagenicity of	2005	18, 87, 136
TDI for	2006	11, 87
COT review of the previously set TDI for	2009	27, 49

Subject: Perfluorooctane sulfonate (PFOS)	Year	Page
Mutagenicity of	2005	17, 87, 136
Tolerable Daily Intake for	2006	11, 110
COT review of the previously set TDI for	2009	27
in the infant diet	2014	16

Subject:

Peripheral blood lymphocytes (PBLs)

Year

Page

Background variation in micronuclei (MN) and chromosomal aberrations (CA)

2006

233, 254

Subject:

Peroxisome proliferators

Year

Page

In hepatocytes

1992

45

Subject: Pesticides	Year	Page
bystander exposure to	2009	8
and health outcomes, Para-occupational exposure to	2009	36
Skin sensitisation from exposure to pesticide	2015	12
Systematic review of the epidemiological literature on para-occupational exposure to pesticides and cancer	2011	55
Ontario College of Physicians report on pesticides	2004	182

Subject:

Persistent organic pollutants

Year

Page

Endosulfan, pentachlorobenzene and chlordecone in the infant diet

2013

18

Subject: Pesticide applicators, biomonitoring studies for genotoxicity in	Year	Page
review of the available studies of genotoxicity in pesticide applicators and workers exposed to pesticides	2004	146
COM and MTP review of literature on	2005	82, 93
Genotoxicity in pesticide applicators, biomonitoring studies for	2004	146

Subject: Phenol	Year	Page
clastogenic effects	2003	132
an updated COM statement on	2008	231
Update statement(2008) on mutagenicity of	2008	252
tolerable daily intake (oral)	2002	15

Subject: 2-Phenylphenol	Year	Page
And its sodium salts in vitro and in vivo mutagenicity	1992	39
Updated COM statement on	1997	64
mutagenicity of 2- phenylphenol and its sodium salt	2003	133

Subject:

Phosphate and the calcium-parathyroid hormone axis

Year

Page

COT evaluation of

2004

11, 54

phosphate, PTH, calcium balance and bone health in detail

2005

19

Subject:

Phosphate-based flame retardants and the potential for developmental toxicity (PFRs)

Year

Page

Scoping paper aimed to investigate the potential for developmental toxicity following exposure to PFRs

2018

29

COT statement on

2019

12

Subject:

Phosphine

Year

Page

Phosphine

2001

103

and metal phosphides

1997

65

Subject:

Phosphorus

Year

Page

Phosphorus, parathyroid hormone and bone health

2003

21

Subject:

Photogenotoxicity testing

Year

Page

Statement on photogenotoxicity testing

2013

43

Subject:

Phthalates

Year

Page

in infant formulae

1996

10

EFSA draft opinion on “Identification and prioritisation for risk assessments of phthalates, structurally similar substances potentially used as plasticisers in materials and articles intended to come into contact with food” and “draft protocol for the exposure assessment as part of the safety assessment of phthalates, structurally similar substances potentially used as plasticisers in materials and articles intended to come into contact with food”

2021

28

Subject:

Physiologically based pharmacokinetic modelling (PBPK)

Year

Page

application of in risk assessment

2019

18

for regulators

2020

22

Subject:

Phytoestrogens research programme

Year

Page

COT is considering the outcomes from the studies on-going at the time of the last external review in 2007 and in combination with the previous external reviews

2011

27

COT evaluation of

2012

14

Subject: Phytoestrogens	Year	Page
in soya-based infant formulae	1998	17,18
In soya-based infant formulas	1999	35
and health, report	2002	20
Phytoestrogens	2003	17
Report on phytoestrogens and health	2002	20

Subject:

Platinum fuel catalyst

Year

Page

Platinum-based fuel catalyst for diesel fuel

1996

12

Subject:

Polybrominated biphenyls (PBBs)

Year

Page

Polybrominated biphenyls (PBBs) in diet of infants

2015

9

Polybrominated biphenyls (PBBs) in diet of infants and 1 – 5 year old children

2015

10

Subject:

Polybrominated diphenylethers (PBDEs) in the diet of infants and young children addendum

Year

Page

COT evaluation of,

2016

16

Subject: Polychlorinated biphenyls (PCBs)	Year	Page
Continued evaluation of,	2017	11
Mutagenicity and carcinogenicity of,	1994	21, 37
assessment of the health hazards of	1997	23
Effects on play behaviour	2002	17
PCDDs, PCDFs and PCBs in marine fish and fish products	1999	31

Subject:

Polychlorinated naphthalenes (PCNs)

Year

Page

in food

2009

28,87

Subject: Polycyclic aromatic hydrocarbons (PAHs)	Year	Page
evaluation of the individual compounds, grouping compounds	1994	19, 34
evaluation of the individual compounds so that priority or representative compounds could be identified for monitoring and/or surveillance.	1995	32
evaluate and rank 25 selected PAHS which could be used as a basis for further monitoring and/or surveillance.	1996	67
Advice on dibenzo(a,l)pyrene	2002	127
In air pollution
in air pollution: A discussion of approaches to risk assessment	2003	135, 192
in air pollution	2004	183
In the 2000 Total Diet Study	2002	16
Pragmatic guideline limits for use in emergencies	2000	27

Subject:

Polyols

Year

Page

sensitivity of young children to

2004

9

Subject: Polyurethane coated breast implants	Year	Page
Polyurethane coated breast implants	1991	46
new information on the degradation and the pharmacokinetics of polyurethane foam in vivo	1994	36
COC evaluation of	2012	44

Subject: Potassium	Year	Page
and sodium ferrocyanides	1994	10
salt replacers in vulnerable groups	2013	30
Potassium-based replacements for sodium chloride and sodium-based additives.	2017	13

Subject:

Potency estimation, developing methods

Year

Page

Ongoing items, for discussion at future meeting

2018

21

Environmental, health and safety alternative testing strategies: Development of methods for potency estimation

2019

19

Subject:

Pregnancy

Year

Page

Vitamin E in

2009

31

Herbal Supplements used in

2020

32

Subject:

Preliminary report by the EU Scientific Committees on Consumer Products, on Health and Environmental Risks, and on Emerging and Newly-Identified Health Risks

Year

Page

on ‘Risk assessment methodologies and approaches for mutagenic and carcinogenic substances’

2008

280

Subject:

Presentation to COC on

Year

Page

In vitro high content screening using patient derived cell models – Dr Steve Dean

2021

77

Subject:

Presentation to COM on

Year

Page

Which mammalian cell tests best complement the Ames test in terms of detecting rodent carcinogens and in vivo genotoxins.’ – Professor David Kirkland

2010

45

Cytokinesis-block (CBMN) assay for the measurement and comparison of Carcinogenic and in vivo genotoxicity potency estimates.’ – Dr Nabil Hajji

2010

46

Subject:

Preservatives

Year

Page

Sodium benzoate and potassium sorbate

2007

134

Subject:

Prioritisation of carcinogenic chemicals

Year

Page

And areas to be developed further,

1994

41

Subject:

Propoxur (Insecticide)

Year

Page

Propoxur

1991

47

Subject:

Propylene carbonate

Year

Page

Propylene carbonate

1992

26

Subject:

Proquinazid (fungicide)

Year

Page

Proquinazid

2005

87, 138

Mutagenicity and Carcinogenicity of

2005

155

Subject: Prostate cancer	Year	Page
an increase in the number of diagnosed cases of	2002	134
The Committee considered an overview report prepared by the DH Toxicology Unit at Imperial College, London.	2003	197
COC review of the available epidemiological and other research to identify if there were any potential chemical exposures which might be associated with	2004	185, 254

Subject: Phthalates	Year	Page
Phthalates – data from the Total Diet Study. Dietary exposure to	2010	27
Ongoing work, TDIs	2010	27
COT evaluation of, dietary co-exposure	2011	8

Subject:

Pyyrolizidine alkaloids in food

Year

Page

and potential human exposure

2007

24

Human exposure, carcinogenicity of

2008

13, 110, 280

COT/COM/COC Annual Report Index

Q - Index

In this guide

Subject:

Quantitative approaches to the assessment of genotoxicity data

Year

Page

COM considered a scoping paper outlining these current approaches and evaluated the potential for data

2016

37

II and First Draft Quantitative risk assessment statement

2017

41

Subject: Quantitative structure-activity relationships (QSAR)	Year	Page
To predict carcinogenicity	2007	182
Use of Quantitative Structure Activity Relationships (QSARs) for Mutagenicity	2011	44
Use of QSAR models, COM guidance on	2021	54

COT/COM/COC Annual Report Index

R - Index

In this guide

Subject:

REACH (Registration, Evaluation and Authorisation of Chemicals)

Year

Page

Technical guidance for derivation of DNELs and risk characterisation of non-threshold effects in the context of

2007

21, 184

Subject:

Refractory ceramic fibres

Year

Page

opinion with regard to the classification of RCFs for carcinogenicity

1995

68

Subject:

Royal Commission on Environmental Pollution (RCEP)

Year

Page

study of long term effects of chemicals

2001

20

crop spraying and the health of residents and bystanders

2006

13, 213, 283

Subject: Reproductive effects of caffeine	Year	Page
COT statement on	2001	41
Awaiting FSA funded research	2007	24
COT statement on	2008	14

Subject: Reproductive outcomes, chlorinated drinking water and	Year	Page
Spontaneous abortion	1998	8
birth outcomes and levels of disinfection by-products in drinking water.	2001	23
adverse reproductive outcomes	2004	8, 46

Subject: Research	Year	Page
and surveys, Food Standards Agency funded	2000	18
priorities and strategy, Department of Health	1996	9, 44, 75
Project(T07040) investigating the effect of mixtures on certain food colours and a preservative on behaviour in children	2007	49

Subject:

Residues

Year

Page

non-permitted additives and veterinary products

2019

17

Subject:

Restriction report

Year

Page

proposal for a restriction: bis(2-ethylhexyl)phthalate (DEHP), benzyl butyl phthalate (BBP), dibutyl phthalate (DBP) and diisobutyl phthalate (DiBP)

2011

18

Subject: Rhizoxin	Year	Page
Enzyme submission COT, revised newlase method to detect	2000	17
Enzyme submission COT, revised newlase method to detect	2002	11
Enzyme submission COT, Newlase was granted full clearance for detection of	2004	10

Subject:

Risk assessment of mixtures of pesticides (and similar substances)

Year

Page

Establishing the working group, cumulative exposure

2000

25

Working group and open consultation meetings, COT report of goals set in 2000

2002

19

Subject: Risk assessment strategies	Year	Page
Guidelines for exposure assessment practice for human health	2003	19
Mixtures of food contaminants and additives	2004	15
Physiologically-based pharmacokinetic modelling	2003	19
RCEP study on pesticides and bystander exposure	2004	18
Uncertainty factors: their use in human health risk assessment by UK government	2003	20
Uncertainty in chemical exposure assessment	2004	21
Use of toxicogenomics in toxicology (update on statement published in 2002)	2004	22
Risk communication	2007	182
Risk procedures used by the Government’s Advisory Committees dealing with food safety	2000	22, 110

Subject:

RNA

Year

Page

RNA Interference

2005

16

RNA related effects as a mechanism of carcinogenicity

2009

228

COT/COM/COC Annual Report Index

S - Index

In this guide

Subject:

Salmonella assay

Year

Page

Use of

1991

35

Subject:

Scientific Committee for Food (SCF)

Year

Page

Guidelines on the Assessment of Novel Foods

1996

13

Subject: Scientific Advisory Committee on Nutrition	Year	Page
report on Iron and Health,	2009	75
Toxicological aspects of the report on iron	2009	29
advice on the effects of high levels of vitamin D intake	2011	28
potential toxicity of vitamin D exposure	2012	21
review of dietary guidelines for vitamin D	2013	31

Subject:

Scientific Committee on Cosmetics and Non-Food Consumer Products (SCCNFP)

Year

Page

SCCNFP testing strategy for cosmetic ingredients

2004

144

Subject:

Science strategy

Year

Page

2005-2010: FSA Draft

2005

14

Subject:

Seaweed

Year

Page

arsenic in. -Urgent advice

2004

13,122

Subject:

Syrian hamster embryo (SHE) cell transformation assay

Year

Page

COM consideration of a modified method

1996

46

Subject: Shellfish	Year	Page
poisoning, amnesic	2001	7
PAHs in,	2001	18
Atypical results in the lipophilic shellfish toxin mouse bioassay	2004	8

Subject:

Short and long chain triacyl glycerol molecules (Salatrims)

Year

Page

COT review of

1997

39

COT updated evaluation

1999

36

Subject: Short-term carcinogenicity tests	Year	Page
Consideration of short-term transgenic mouse models	1997	114
using transgenic animals, by Dr Denise Robinson	1999	73
using transgenic animals	2002	131

Subject:

Single cell protein

Year

Page

Food safety clearance of a novel,

1996

14

Subject:

Soil

Year

Page

Contaminants in

2001

10

Subject:

Soluble fibre derived from guar gum

Year

Page

toxicology studies which had been carried out on novel fibre itself

1996

15

COT statement on

1997

46

Subject:

Soy phytoestrogens

Year

Page

Soy phytoestrogens in the infant diet

2013

23, 31

Effect of soy phytoestrogen supplementation on thyroid status and cardiovascular risk

2011

27

Subject: Soya	Year	Page
Soya consumption and thyroid status	2015	13
Soya drinks, in the diet of infants aged 1-5	2019	19
Soya drinks, in the diet of infants aged 1-5	2020	29
Statement on the consumption of plant-based drinks (almond, soya, oat)	2021	11
Soya in wheat flour, allergen risk assessment for adventitious contamination of milled and consumed in the UK	2020	20

Subject:

Statistical significance

Year

Page

Biological relevance and

2020

64

Subject:

Sterigmatocystin (Mycotoxin)

Year

Page

Sterigmatocystin

1998

19

Subject: Sucralose	Year	Page
in vivo unscheduled DNA synthesis (UDS) assay in the liver	1993	34
in vitro liver UDS assay consideration	1994	24
Teratogencity in rabbits	2000	23

Subject:

Sudan I

Year

Page

Sudan I found in chilli powder

2003

16

Subject:

Sulphur dioxide

Year

Page

Sulphur dioxide

1991

19, 30

Subject:

Survey guidelines

Year

Page

for project officers

2001

22

Subject:

Swimming pool disinfection by-products

Year

Page

and genotoxicity assessment

2013

44

COT/COM/COC Annual Report Index

T - Index

In this guide

Subject: Terephthalic acid	Year	Page
In vitro and in vivo mutagenicity	2001	87
endocrine disrupting effects, urinary bladder and the kidney	2003	13
In vivo mutagenicity	2007	135
TDI and updated COT statement on	2008	16
and isophthalic acids in food	2000	24
multigenerational reproduction study additional histopathological examinations	2005	10
Update statement on the Toxicology of	2008	21

Subject:

Toxins

Year

Page

T2-toxin and HT2-toxin and neosolaniol in the diet of infants aged 0-1 and young children aged 1-5 years.

2018

15

Subject: Test strategies and evaluations	Year	Page
Continued advice, OECD recommendations, standardisation of genotoxicity test procedures	1993	39
finalise the updating of 7 existing guidelines and to consider 2 new guidelines.	1994	25
interpretation of genotoxicity tests chemical mutagenesis	1995	37
advice on strategies in carcinogenicity for the ongoing discussions of the International Conference on	1996	44
Harmonisation of the Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH).	1996	75
test strategies and interpretation of genotoxicity tests in the context of the discussions of the Genotoxicity Working Party of the International Conference on Harmonisation of the Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH).	1997	75, 112
review of its guidelines for the testing of chemicals for mutagenicity	1998	34, 50
revision of guidelines on an appropriate strategy for the testing of chemicals for mutagenicity & evaluation of chemically induced aneuploidy and in particular the extrapolation of data from somatic cells to germ cells.	2000	63
In vitro micronucleus test	2002	88
ILSI/HESI research programme on alternative cancer models: results of Syrian hamster embryo cell transformation assay	2002	87
IGHRC paper on uncertainty factors	2002	129
Minimum duration of carcinogenicity studies in rats	2002	130
Short term tests for carcinogenicity. (ILSI/HESI research programme on alternative cancer models)	2002	131
The investigation of interaction between genotype and chemicals in the environment on the induction of cancer	2002	132
In-vitro Mammalian cell mutation assays	2003	137
Strategy for investigating germ cell mutagens	2003	138
Significance of in-vivo mutagenicity at high doses	2003	139
COC guidance on a strategy for risk assessment of carcinogens	2004	188 to 190
COT/COC/COM review of toxicogenomics	2004	190, 191
approaches to test strategies for chemicals which were positive in in vitro mutagenicity tests	2006	240
TK6 GADD45a GFP genotoxicity assay as an early screening assay to be undertaken prior to in-vitro mutagenicity testing.	2007	137
development of an OECD guideline for the in vitro micronucleus test	2007	137
Review of COM Guidance 2000	2008	234
Risk assessment of in-vivo mutagens (and genotoxic carcinogens)	2001	89
Tobacco induced lung carcinogenesis: The importance of p53 mutations	2001	89
International Workshop on the Categorisation of Mutagens	2001	90

Subject:

Testicular cancer

Year

Page

Review of the possible chemical aetiology of,

2006

284

Subject: 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)	Year	Page
as a possible human carcinogen	1993	49
Developmental and reproductive toxicity, Immunotoxicity, Carcinogenicity, Exposure from human milk	1995	15, 64
Review, Consideration of IARC Monograph Published in 1997	1998	45
review of the relevant literature published since 1990	1999	49
Carcinogenicity of	2001	115

Subject: Tetrabromobisphenol A (TBBPA)	Year	Page
Tetrabromobisphenol A	2004	12
review of toxicological data	2004	62
in the infant diet	2014	19

Subject: Tetrachloroethylene	Year	Page
Perchloroethylene, risk of developmental toxicity	1993	21, 48
review the animal and human carcinogenicity data on this compound with particular reference to the recent epidemiology	1996	37, 68
reproductive and developmental toxicity arising from exposure to	1997	47

Subject:

Thalidomide

Year

Page

Mutagenicity of,

1997

62

Subject: Thiabendazole	Year	Page
development of the fetus	1991	20
developmental toxicity	1995	20
as a potential in-vivo aneugen	1996	40
COT evaluation of ; ADI	1997	50

Subject:

Thiamphenicol

Year

Page

potential to cause idiopathic blood dyscrasia

1992

26

Subject: Thresholds for aneuploidy inducing chemicals	Year	Page
in-vivo assays	1995	37
Studies on Benomyl and Carbendazim	1996	42
Thresholds for in vivo mutagens	2009	151
Threshold for benzene induced carcinogenicity, Consideration of evidence for	1998	32

Subject:

Titanium dioxide

Year

Page

Review of 2021 EFSA opinion

2021

23, 60

Interim position paper, ongoing work

2021

37

Subject: Tobacco	Year	Page
toxicological evaluation of tobacco, ingredients and additives used in the manufacture of tobacco, and its emission products.	2008	14
genotoxicity of	2009	53
Reassessment of the toxicological testing of tobacco	2004	19, 107,
Reassessment of toxicology of tobacco products	2004	142, 186
Carcinogenicity testing of	2009	219
reassessment of the toxicological testing of	2004	19, 107
reassessment of the toxicology of	2004	142, 186
Tobacco induced lung carcinogenesis: the importance of p53 mutations	2001	107

Subject:

Toltrazuril

Year

Page

Advice on,

1992

57

Subject: Toxicity of chemicals in the infant diet; and the diet of young children aged 1 to 5 years	Year	Page
Aluminium, lead, vitamin A, soy phytoestrogens	2012	22
α-, β- and γ-hexachlorocyclohexanes and perfluorooctane sulphonate	2013	32
Reviews of vitamin A, iodine and nickel commenced in 2016 and will continue in 2017	2016	22
manganese, chromium and copper	2017	27
Mycotoxins were reviewed in 2017 and full reviews of T2,HT2 and neosolaniol and ochratoxin A commenced in 2017.	2017	27
Statements on nickel and cadmium had been finalised in 2017	2017	28

Subject: Toxicogenomics	Year	Page
in toxicology, ongoing review of new relevant in vitro studies	2007	137, 185
COM ongoing review	2008	235
COT/COC/COM update their joint statement on toxicogenomics published in 2004	2009	60
as a tool for identifying genotoxic carcinogens	2013	46
use of in toxicology (update on statement published in 2002)	2004	22, 112
COT/COC/COM review of	2004	144
in toxicology – design, analysis and statistical issues	2010	29
Toxicological aspects of the SACN report on Iron	2009	29
In toxicology testing, presentation on	2021	58
Toxicological evaluation of chemical analyses carried out as part of a pilot study for a breast milk archive	2004	14, 70
Toxicogenomics data in risk assessment	2012	16
ToxTracker	2019	34, 52
Transgenerational Epigenetics, Workshop on	2008	19, 36
Use of toxicogenomics in toxicology (update on statement published in 2002).	2004	22, 112

Subject:

Transgenerational Epigenetics

Year

Page

Workshop and implications for risk assessment

2008

19,36

Environmental toxicant induced, presentation on

2021

56

Subject: Transgenic animal models	Year	Page
Transgenic animal models, Use in short terms tests for carcinogenicity	2001	142
Transgenic mouse models	1997	114
Validation of short-term carcinogenicity tests using transgenic animals, Presentation on	1999	73

Subject:

Trichloroethylene

Year

Page

Trichloroethylene

1996

39, 71

Subject:

Trihalomethanes in drinking water

Year

Page

Chloroform, Bromodichloromethane [BDCM], Chlorodibromomethane [DBCM] and Bromoform

1994

22, 32, 69

Bromodichloromethane, Chlorodibromomethane, and Bromoform.

1995

35

Subject:

Tryptophan and eosinophilia-myalgia syndrome

Year

Page

risk to health of tryptophan, particularly in food supplements

2003

21

one or more contaminants in several batches of tryptophan produced by one manufacturer

2004

12, 83

Subject:

Tryptophan in food

Year

Page

responses to consultation on revision of Regulations

2005

11

Subject:

Turmeric

Year

Page

supplements- potential; hepatotoxicity of

2019

16

Subject:

Type 1 caramel

Year

Page

Mutagenicity data,

1991

30

COT/COM/COC Annual Report Index

U - Index

In this guide

Subject:

Unlicensed traditional remedies

Year

Page

adverse effects in individuals consuming,

1994

10

Subject: Uncertainty	Year	Page
risk assessment process highlighting areas of toxicological uncertainty	2001	17
uncertainty in the toxicological hazard aspects of human health risk assessment.	2002	129
Uncertainty in chemical exposure assessment	2004	21
Assessment of the adequacy of the 10-fold uncertainty factor to allow for interspecies variation in developmental toxicity	2013	29
Expression of uncertainty	2012	13
Expression of uncertainty	2010	26

Subject:

Uranium levels in water used to re-constitute infant formula

Year

Page

COT ongoing work, the discussion will be completed in 2006

2005

18

TDIs and exposure, in vivo uranium toxicity in rats

2006

14, 196

COT/COM/COC Annual Report Index

V - Index

In this guide

Subject: Variability and Uncertainty in Toxicology – working group	Year	Page
The working group held an open symposium in February 2004 in Cardiff	2004	15, 18
preliminary draft report, a draft report will be published for consultation early in 2006	2005	14
in the biological data utilised in the risk assessment of chemicals in food	2006	19
in Toxicology of Chemicals in Food, Consumer Products and the Environment (VUT Report).	2007	23

Subject: Vitamin A	Year	Page
possible risks from high levels of vitamin A in the infant diet.	2013	24
The COT review of, in children aged 1- 5 years.	2017	15
ongoing work on the COT contribution to the SACN risk assessment on nutrition and,	2021	33

Subject: Vitamin D	Year	Page
advice on the effects of high levels of vitamin D intake	2011	28
potential toxicity of vitamin D exposure	2012	21
review of dietary guidelines for vitamin D	2013	31
Vitamin D, adverse effects of high levels	2014	6
ongoing work on the COT contribution to the SACN risk assessment on nutrition and,	2021	31

Subject: Vitamin E	Year	Page
in pregnancy	2009	31
And prostate cancer statement, epidemiological, animal and in vitro studies	2012	47
Ongoing review of the information available on vitamin E and prostate cancer, including epidemiological, animal and in vitro studies on this topic.	2013	57
review the information available on vitamin E and prostate cancer, including epidemiological, animal and in vitro studies on this topic as well as to peer-review the SELECT study.	2015	48

Subject:

Vitamins and minerals

Year

Page

Ad hoc expert group (EVM)

1997

6

European Commission document on establishing maximum

and minimum levels in dietary supplements and fortified

foods

2006

15

COT/COM/COC Annual Report Index

W - Index

In this guide

Subject: Working Groups	Year	Page
SEES: a subgroup to review the approaches to synthesising epidemiological evidence that are used by the Committees in chemical risk assessments and to make recommendations for COT/COC guidance.	2017	24, 54
Executive summary of	2018	25
Working Group: COT/COC Subgroup on synthesising epidemiological and toxicological evidence	2019	14,52
Working Group: COT/COC Subgroup on synthesising epidemiological and toxicological evidence	2021	38
Working Group: COT/SACN Subgroup on the timing of introduction of allergenic foods into the infant diet.	2017	24
Working Group: COT/SACN Subgroup on plant-based drinks	2021	39
Working Group on the review of epidemiological literature on organophosphates and health outcomes relating to the nervous system	2012	19

Subject: Waste and Resources Action Programme (WRAP)	Year	Page
biological and chemical risks associated with the use of composts from different source segregated feedstocks across a range of agricultural sectors.	2009	37
Confidence in Compost Programme, risk assessments	2010	29
Potatoes and acrylamide, study on	2020	17
use of PAS 100-compliant composts and PAS 110-compliant anaerobic digestates in agriculture	2013	26
WRAP risk assessment on anaerobic digestates	2011	20

Subject:

Wild fungi

Year

Page

and blackberries, Multielement survey of

1999

28

Subject: Working Group on Variability and Uncertainty in Toxicology (VUT)	Year	Page
Open symposium	2004	15, 18
Draft report of,	2005	14
in the biological data utilised in the risk assessment of chemicals in food	2006	19
Final report of,	2007	23

COT/COM/COC Annual Report Index

X - Index

In this guide

Subject:

Xylanase

Year

Page

preparation from Aspergillus niger

2001

13

COT/COM/COC Annual Report Index

Y - Index

In this guide

COT/COM/COC Annual Report Index

Z - Index

In this guide

Subject:

Zearalenone (Mycotoxin)

Year

Page

Mutagenicity of,

1998

29

Subject:

Zebrafish (Danio rerio)

Year

Page

use of, in biomedical research.

2014

44

COT/COM/COC Annual Report Index

A - Index

In this guide

Index to Subjects and Substances considered in previous annual reports of the Committees on Toxicity, Mutagenicity and Carcinogenicity of Chemicals in Food, Consumer Products and the Environment.

Accelerator Mass Spectrometry

Acceptable Daily Intakes (ADI)

Acetyl tributyl citrate (ATBC)

Acid sweets

Aclonifen

Acrylamide

Acute toxicity testing

Ad hoc Expert Group on Vitamins and Minerals (EVM)

Additives, food

Advances in toxicology

Adverse birth outcomes

Adverse Outcome Pathways

Advisory Committee on Novel Foods and Processes (ACNFP),

Agaritine

Aircraft cabin air environment, ill-health in aircraft crew and the possible relationship to smoke/fume events in aircraft

Air fresheners

Air pollution

Alcohol and alcoholic beverages (also see ethanol)

Alitame

Almond drinks

Alternaria toxins

Allergenic foods

Aluminium

Amalgam, Dental

Amano 90 (enzyme)

Ammonium Phosphatides (Emulsifier YN)

Amnesic Shellfish Poisoning

Aneuploidy

Aniline

Antimony trioxide

Arsenic

Asbestos

Aspartame

Astaxanthin

Autoimmune disease

Avoparcin

Azodicarbonamide

B - Index

In this guide

Subject:

Benchmark dose modelling in risk assessment

Benz(a)pyrene

Benzene

Benzimidazoles

Betal quid, pan masala and areca nut chewing

Biobank project

Biologically based food contact materials

Biomonitoring

Biomonitoring studies for genotoxicity in pesticide applicators

Bisphenol A

Bisphenol A diglycidyl ether (BADGE)

Bitter Apricot Kernels

Boron

Bracken

Breast cancer alcohol and

Breast cancer, organochlorine insecticides and

Breast implants

Breast milk

Bromate

Brominated compounds

Bromine, fluorine, and iodine

1,3-Butadiene

Butylated hydroxyanisole (BHA)

Bystander Risk Assessment Working Group (BRAWG)

C - Index

In this guide

Cadmium,

Caffeine

Calcium-parathyroid hormone axis

Cancer

Cancer aetiology

Cancer incidence near municipal solid waste

incinerators

Cancer risk

Cannabidiol (CBD)

Canned foods