Joint COT and COC Synthesis and Integration of Epidemiological and Toxicological Evidence subgroup

Last updated:
29 May 2020
To review the approaches to synthesising and integrating epidemiological and toxicological evidence that are used by COT and COC in chemical risk assessments and to provide a pragmatic guidance and transparent reflection of how the COT and COC review data and apply expert judgement.

Members of the COT and COC SETE subgroup


Professor Alan Boobis OBE PhD FBTS FBPhS
Emeritus Professor of Toxicology in the Faculty of Medicine at Imperial College London.


Dr Phil Botham BSc, PhD, FRCPath, FBTS
Principle Science Advisor, Syngenta

Dr Gil Clare PhD
Consultant in Genetic Toxicology

Professor Gunter Kuhnle PhD
Professor of Nutrition and Health at University Reading

Dr George Loizou
Strategic research for the Health and Safety Executive (HSE) on computational tools, quantitative risk assessment and physiological based pharmacokinetics (PBPK) modelling

Dr David P Lovell PhD BSc (Hons) FSB  CStat CBiol CSci
Emeritus Reader in Medical Statistics, St George’s Medical School, University of London

Professor Neil Pearce BSc DipSci DipORS PhD DSc FRSNZ FMedSci FFPH
Professor of Epidemiology and Biostatistics, London School of Hygiene and Tropical Medicine

Dr Lesley Rushton OBE, Hon FFOM, BA, MSc, PhD CStat
Emeritus Reader in Occupational Epidemiology, Imperial College London

Professor Mireille B. Toledano
Chair in Perinatal & Paediatric Environmental Epidemiology, Faculty of Medicine, School of Public Health, Imperial College London

Professor Heather Wallace PhD FRCPath FRSC FRSB FBPhS ERT
Professor of Biochemical Pharmacology and Toxicology, Institute of Medical Science, University of Aberdeen


There are a number of guidance documents and frameworks available on the use of epidemiological and toxicological information in chemical risk assessment, however the majority assesses these two evidence streams separately and subsequently bring them together qualitatively, using expert judgment. These frameworks and guidance documents generally provide little information on how toxicological and epidemiological data should be integrated in a transparent manner, giving appropriate weight to both. It was therefore proposed that a joint COT and COC subgroup be set up to review and make publicly available a pragmatic guidance document and a transparent reflection of how the Committees review such data and apply expert judgment.

Terms of Reference

To provide pragmatic guidance that can be used by expert advisory committees for synthesis and integration of epidemiological and toxicological evidence, for example:
• To review and interpret data involving epidemiological and toxicological studies
• To review recent practices and frameworks by other expert Committees on epidemiological and toxicological evidence, with a focus on integrating the two evidence streams
• To identify key points of current approaches and apply them to the work of COT and COC, where applicable
• To identify and make recommendations for areas that require further work

More in this section