COT-COC Synthesising epidemiological evidence subgroup

Last updated:
6 July 2015
To review the approaches to synthesising epidemiological evidence that are used by COT and COC in chemical risk assessments and to make recommendations for COT/COC guidance.


There have been a number of recent initiatives providing new or updated guidelines to help inform the synthesis of evidence of epidemiological  studies for input into policy. As COC are also looking at reviewing their literature review process, it is proposed that a joint COT/COC subgroup is set up to review and make publicly available general principles of systematic literature review relating to review of epidemiological studies and how these can be integrated with toxicological evidence.

Terms of reference

To provide guidance that can be used by expert advisory committees for synthesis of epidemiological evidence, for example for:

  • Interpreting systematic reviews involving epidemiological studies
  • Conduct of reviews and systematic reviews of epidemiological studies
  • Synthesis of evidence not involving systematic reviews

-To review recent practice by expert advisory committees for synthesis of epidemiological evidence, with a focus on systematic reviews

-To identify key points of current best practice methodologies used in systematic review and meta-analysis

-To identify and make recommendations for areas requiring further work

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