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Glucosamine is a popular food supplement taken alone or in combination with chondroitin sulphate. In view of a small number of case reports linking glucosamine and hepatitis, including one that became the subject of a Scottish Fatal Accident Inquiry, the COT was asked to consider whether a causal association between glucosamine and hepatitis was plausible.
In February 2009 the Committee held a workshop where invited experts described recent advances in toxicogenomics, computational toxicology, metabonomics and high-throughput screening. The emphasis was on obtaining greater mechanistic understanding, which informs risk assessment and provides a basis for predictive toxicology. This statement summarises the presentations and Committee discussions.
The Committee was asked to review the available information on occurrence and potential toxicity of methylglyoxal (MG) in foods. MG is possibly an intermediate in the formation of acrylamide in foods and elevated biological levels of MG have been associated with a number of diseases. The Committee looked at the available evidence and produced the following statement.
Chlorinated paraffins (CPs) are a large group of several thousand individual chemicals. The Committee was asked for advice on possible risks associated with the levels of CPs in foodstuffs that had been found in a Food Standards Agency (FSA) investigation.
Polychlorinated naphthalenes (PCNs) are a group of 75 congeners, with structures similar to those of polychlorinated dibenzo-p-dioxins and -furans (PCDDs and PCDFs). The Committee was asked for advice on possible risks associated with the levels of PCNs in foodstuffs that had been found in a Food Standards Agency (FSA) investigation.
The COT set a tolerable daily intake (TDI) for Perfluorooctanoic acid (PFOA) in 2006. The European Food Safety Authority (EFSA) and the US Environmental Protection Agency (US EPA) have derived a TDI and a Provisional Health Advisory Value, respectively, using the same toxicity endpoint but using different uncertainty factors. Hence the COT was invited to re-evaluate the TDI previously recommended.