COT statement on a consideration of toxicological data for some structured triglycerides composed of mixtures of short and long chain fatty acids

The COT was asked by the Advisory Committee on Novel Foods and Processes (ACNFP) of the Ministry of Agriculture, Fisheries and Food and the Department of Health to consider data submitted on the toxicology of a family of structured triglycerides (Salatrims) intended for use as low calorie fats.

The Committee was specifically asked about the adequacy of the toxicological database and to evaluate the changes in serum enzymes reported in human clinical studies. It considered that the animal toxicological data alone were insufficient to evaluate the proposed use of these materials as fat replacers and recommended that a suitable long term clinical evaluation study should be undertaken.

Further details are available from the ACNFP Annual Report for 1997.