COT statement on the toxicity of dental amalgam

The COT was asked to advise the Medical Devices Agency on the toxicity of dental amalgam in the context of informing the United Kingdom's response to the report of an ad hoc group of experts established by the European Commission.

The Committee consider that their former conclusions (of 1986) are unchanged with regard to the rare occurrence of hypersensitivity and the lack of risk of systemic toxicity.

The Committee concluded that there is no evidence that the placement or removal of amalgam fillings during pregnancy was harmful. However, the Committee noted that the toxicological and epidemiological data are inadequate to assess fully the likelihood of harm occurring in such circumstances and concurred with the view that it may be prudent to avoid, where clinically reasonable, the placement or removal of amalgam fillings during pregnancy.