COT statements and position papers

COT statements are the main form in which the Committee presents its advice. Position papers are short overviews produced more quickly than full statements. They can be viewed by topic or by year.

By topic
A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | UVW | XYZ


Acid sweets:
Adverse reactions to acid sweets (2004)

Additives
Research project (TO7040) investigating the mixtures of certain food colours and a preservative on behaviour in children (2007)
Food additives and developmental neurotoxicity (2006)
Research project investigating the effect of food additives on behaviour (2002)

Aluminium
Potential risks from aluminium in the infant diet (2013)

Amnesic shellfish poisoning
Amnesic shellfish poisoning (2001)

Arsenic
Arsenic in food: results of the 1999 total diet study (2003)

^Top


Bitter apricot kernels
Cyanogenic glycosides in bitter apricot kernels (2006)

Bisphenols
Study of bisphenols in canned foods (2001)
Bisphenol A (1997)
Bisphenol A diglycidyl ether (BADGE) in canned foods (1997)

Bracken
Risk to consumers of eating foods derived from animals that have eaten Bracken (2008)

Breast implants
Further toxicity studies in the rat of a hydrogel filler for breast implants (2006)
Further toxicity study in the rat of a hydrogel filler for breast implants (2002)
Toxicity study in the rat of a hydrogel filler for breast implants (2000)

Breast milk
Toxicological evaluation of chemical analyses carried out as part of a pilot study for a breast milk archive (2004)
Health hazards of polychlorinated biphenyls (1997)

Bromine
Organic chlorinated and brominated contaminants in shellfish, farmed and wild fish (2006)
Brominated flame retardants in fish from the Skerne-Tees rivers system (2004)
Tetrabromobisphenol A - review of toxicological data (2004)
1997 Total Diet Study - Fluorine, Bromine, and Iodine (2000)

^Top


Cabin air environment
Review of the cabin air environment, ill-health in aircraft crews and the possible relationship to smoke/fume events in aircraft (2007)
Review of possible adverse health effects in the crew of commercial aircraft (2013)

Caffeine
Reproductive effects of caffeine (2001)
Reproductive effects of caffeine (2008)

Chlorine
Polychlorinated naphthalenes in food (2009)
Chlorinated paraffins in food (2009)
Chlorination disinfection by-products and risk of congenital anomalies in England and Wales (2008)
Organic chlorinated and brominated contaminants in shellfish, farmed and wild fish (2006)
Chlorinated water and reproductive outcomes (2004)
Chlorinated drinking water and reproductive outcomes (1999)
Safety-in-use of chlorine and chlorine dioxide as flour treatment agents (1996)

Crop spraying
Crop spraying and the health of residents and bystanders (2006)

2-Chlorobenzylidene Malonitrile (CS spray)
Combined exposure to 2-Chlorobenzylidene Malonitrile (CS) and PAVA (Nonivamide) sprays (2006)
2-chlorobenzylidene malononitrile and CS spray (1999)

Cyanogenic glycosides
Cyanogenic glycosides in bitter apricot kernels (2006)

^Top


Diethyl-m-toluamide (DEET)
Review of toxicology literature on the use of topical insect repellent diethyl-m-toluamide (DEET) update (2006)
Review of toxicology literature on the use of topical insect repellent diethyl-m-toluamide (DEET) (2002)

Dental amalgam
Toxicity of dental amalgam (1997)

Developmental neurotoxicity
Food additives and developmental neurotoxicity (2006)

Diet-drug interactions
COT/CSM one day meeting on diet-drug interactions (2006)

Dioxins
Occurrence of mixed halogenated dioxins and biphenyls in UK food (2010)
FSA funded study investigating the developmental effects of dioxin (TCDD) in rats (2007)
2005 WHO equivalency factors for dioxins and dioxin-like compounds (2006)
Tolerable daily intake for dioxins and dioxin-like polychlorinated biphenyls (2001)
Dietary exposure to dioxins and dioxin-like PCBs (2000)
Dioxins and dioxin-like PCBs in free-range eggs (2000)

Disinfectants
Chlorination disinfection by-products and risk of congenital anomalies in England and Wales (2008)
Commercial survey investigating the occurrence of disinfectants and disinfection by-products in prepared salads (2006)

^Top


Eggs
Dioxins and dioxin-like PCBs in free-range eggs (2000)

Elements
Results of a multi-element survey of fungi and blackberries (2000)
Results of multi-element surveys (1998)

Endosulfan isomers, pentachlorobenzene and chlordecone
Endosulfan isomers, pentachlorobenzene and chlordecone (2014)

Epigenetics
Workshop on transgenerational epigenetics (2008)

^Top


Fish and shellfish
Organic chlorinated and brominated contaminants in shellfish, farmed and wild fish (2006)
Brominated flame retardants in fish from the Skerne-Tees rivers system (2004)
Survey of mercury in fish and shellfish update (2004)
Survey of mercury in fish and shellfish (2003)
Tetrabromobisphenol A - review of toxicological data (2004)
Amnesic shellfish poisoning (2001)
Results of a survey for PCDDs, PCDFs and PCBs in Marine Fish and Fish Products (1999)
Surveillance for malachite green and leucomalachite green in farmed fish (1999)

Fluorine
Fluorine in the 1997 Total Diet Study (2003)
1997 Total Diet Study - Fluorine, Bromine, and Iodine (2000)

^Top


Genetic modification
Studies of potatoes genetically modified to produce Galanthus nivalis lectin (2000)
Studies of potatoes genetically modified to produce Galanthus nivalis lectin (1999)

Genomics and Proteomics
Symposium on the use of Genomics and Proteomics in Toxicology (2002)

Glucosamine
Glucosamine and hepatotoxicity (2009)

Gluten
COT joint statement on the timing of introduction of gluten into the infant diet (2011)

^Top

Halogenated contaminants
Occurrence of mixed halogenated dioxins and biphenyls in UK food (2010)
Organic chlorinated and brominated contaminants in shellfish, farmed and wild fish (2006)

Hepatotoxicity
Glucosamine and hepatotoxicity (2009)

Hexabromocyclododecanes (HBCDDs)
Hexabromocyclododecanes (HBCDDs) (2015)

Hexachlorobutadiene
Hexachlorobutadiene (2000)

Hexachlorocyclohexanes
Hexachlorocyclohexanes (HCHs) (2014)

Hydrolysed formula
Hydrolysed cows’ milk formulae (2016)

^Top


Idiopathic Environmental Intolerance (IEI)
Idiopathic Environmental Intolerance (2011)

Infant food and formulae
Hydrolysed cows’ milk formulae (2016)
Phytoestrogens (2013)
High levels of vitamin A in the infant diet. (2013)
Potential risks from lead in the infant diet (2013)
Potential risks from aluminium in the infant diet (2013)
COT joint statement on the timing of introduction of gluten into the infant diet (2011)
Uranium levels in water used to reconstitute infant formula (2006)
Metals in infant food (2003)
Phthalates in infant formulae (1996)
Endosulfan isomers, pentachlorobenzene and chlordecone (2014)
Hexachlorocyclohexanes (HCHs) (2014)
Polybrominated biphenyls (PBBs) in the infant diet (2015)
Polybrominated diphenyl ethers (PBDEs) (2015)
Hexabromocyclododecanes (HBCDDs) (2015)

Iodine
1997 Total Diet Study - Fluorine, Bromine, and Iodine (2000)
Iodine in cows' milk (2000)
Iodine in cows' milk (1997)

^Top


Landfill sites
COT second statement on landfill sites (2010)
study by the Small Area Health Statistics Unit (SAHSU) on health outcomes in populations living around landfill sites (2001)

Lay summaries
Use of toxicogenomics data in risk assessment (2012)
Proposal for a restriction: DEHP, BBP, DBP, DiBP (2011)
Para-occupational exposure to pesticides and health outcomes (2011)
Dietary exposure to phthalates - data from the Total Diet Study (2011)
Idiopathic environmental intolerance (2011)
Effects of chronic dietary exposure to methanol (2011)
Occurrence of mixed halogenated dioxins and biphenyls in UK food (2010)
Tolerable daily intake for dioxins and dioxin-like polychlorinated biphenyls (2001)

Lead
Potential risks from lead in the infant diet (2013)

^Top


Malachite green
Surveillance for malachite green and leucomalachite green in farmed fish (1999)

Male reproduction
Development and function in adulthood of the human male reproductive system - potential chemical-induced effects (2006)
Male reproduction (2004)

Marine biotoxins
Risk assessment of marine biotoxins of the okadaic acid, pectenotoxin, azaspiracid and yessotoxin groups in support of human health (2006)
Amnesic shellfish poisoning statement (2001)

Mercury
Survey of mercury in fish and shellfish update (2004)
Survey of mercury in fish and shellfish (2003)
Toxicity of dental amalgam (1997)

Metals
2006 Total Diet Study - metals and other elements (2008)
2000 Total Diet Study - 12 metals and other elements (2004)
Metals in infant food (2003)
Results of a multi-element survey of fungi and blackberries (2000)
Results of multi-element surveys (1998)

Methanol
Effects of chronic dietary exposure to methanol (2011)

Methylglyoxal
Methylglyoxal (2009)

Milk
Toxicological evaluation of chemical analyses carried out as part of a pilot study for a breast milk archive (2004)
Iodine in cows' milk (2000)
Iodine in cows' milk (1997)
Health hazards of polychlorinated biphenyls (1997)

Mycotoxins
Surveillance for the mycotoxin moniliformin (1998)
Surveillance for the mycotoxin sterigmatocystin (1998)

^Top


Nanomaterial toxicology
Addendum to Joint statement on nanomaterial toxicology (2007)
Joint statement on nanomaterial toxicology (2005)

New methodologies
COT workshop on 21st century toxicology (2009)
Joint statement of the use of toxicogenomics in toxicology (2004)
Physiologically based pharmacokinetic modelling (2003)
Symposium on the use of Genomics and Proteomics in Toxicology (2002)

Nitrate metabolism
Nitrate metabolism in man (1999)

^Top


Ochratoxin A
Ochratoxin A on dried vine fruits (1997)

Organophosphates
Statement on Organophosphate (2014)

^Top


Paralytic shellfish poisoning (PSP)
Risk assessment and monitoring of paralytic shellfish poisoning (PSP) toxins in support of human health (2006)

Parathyroid hormone axis
Phosphate and the calcium parathyroid hormone axis (2005)

PAVA (Nonivamide)
Combined exposure to 2-Chlorobenzylidene Malonitrile (CS) and PAVA (Nonivamide) sprays (2006)
Joint statement on 2-chlorobenzylidene malononitrile and CS spray (1999)

Peanuts
Review of the 1998 COT recommendations on peanut avoidance (2008)

Perfluorooctane
Tolerable daily intake for perfluorooctanoic acid (2009)
Tolerable daily intake for perfluorooctane sulfonate (2006)
Tolerable daily intake for perfluorooctanoic acid (2006)

Pesticides
FSA-funded research and other progress on mixtures of pesticides and similar substances(2011)
Para-occupational exposure to pesticides and health outcomes (2011)

Phthalates
Dietary exposure to phthalates - data from the Total Diet Study (2011)
Phthalates in infant formulae (1996)

Pine bark
Supplements containing French maritime pine bark extracts (1999)

Polybrominated biphenyls (PBBs) in the infant diet
Polybrominated biphenyls (PBBs) in the infant diet (2015)

Polybrominated diphenyl ethers (PBDEs)
Polybrominated diphenyl ethers (PBDEs) (2015)

Polycyclic Aromatic Hydrocarbons (PAHs)
Polycyclic Aromatic Hydrocarbons - interim pragmatic guideline limits for use in emergencies (2001)

Polychlorinated dibenzo-p-dioxins (PCDDs), Polychlorinated dibenzofurans (PCDFs) and Polychlorinated biphenyls (PCBs)
Polychlorinated naphthalenes in food (2009)
Tolerable daily intake for dioxins and dioxin-like polychlorinated biphenyls (2001)
Dietary exposure to dioxins and dioxin-like PCBs (2000)
Dioxins and dioxin-like PCBs in free-range eggs (2000)
Results of a survey for PCDDs, PCDFs and PCBs in Marine Fish and Fish Products (1999)
Health hazards of polychlorinated biphenyls (1997)

Pharmacokinetic modelling
Physiologically based pharmacokinetic modelling (2003)

Phenol
Phenol: tolerable daily intake (oral) (2002)

Potassium
Potassium position paper (2014)

Phytoestrogens
Statement on Phytoestrogens (2013)
Phytoestrogens (1996)
Phystoestrogens research programme (2012)

Pyrrolizidine Alkaloids
Pyrrolizidine Alkaloids in Food (2008)

^Top


Reproduction
Development and function in adulthood of the human male reproductive system - potential chemical-induced effects (2006)
Male reproduction (2004)
Chlorinated water and reproductive outcomes (2004)
Reproductive effects of caffeine (2001)
Chlorinated drinking water and reproductive outcomes (1999)
Tetrachloroethylene and the reproductive health of workers in the dry-cleaning industry (1997)

Risk assessment
COT workshop on evolving approaches to chemical risk assessment (2007)
Risk assessment of marine biotoxins of the okadaic acid, pectenotoxin, azaspiracid and yessotoxin groups in support of human health (2006)
Risk assessment and monitoring of paralytic shellfish poisoning (PSP) toxins in support of human health (2006)

^Top


Salatrims / Structured triglycerides
Consideration of toxicological data for some structured triglycerides (Salatrims) composed of mixtures of short and long chain fatty acids (2000)
Toxicological aspects of a submission on Salatrims, for ACNFP (1999)
Salatrims for ACNFP (1997)

Shellfish
Domoic acid in king scallops (Pecten Maximus) (2014)
Organic chlorinated and brominated contaminants in shellfish, farmed and wild fish (2006)
Risk assessment of marine biotoxins of the okadaic acid, pectenotoxin, azaspiracid and yessotoxin groups in support of human health (2006)
Risk assessment and monitoring of paralytic shellfish poisoning (PSP) toxins in support of human health (2006)
Brominated flame retardants in fish from the Skerne-Tees rivers system (2004)
Tetrabromobisphenol A - review of toxicological data (2004)
Survey of mercury in fish and shellfish (2003)
Amnesic shellfish poisoning (2001)

Soya
Statement on Phytoestrogens (2013)

Sterigmatocystin
Results of a survey for Sterigmatocystin in foodstuffs (2000)
Surveillance for the mycotoxin sterigmatocystin (1998)

Supplements
Supplements containing French maritime pine bark extracts (1999)

^Top


Terephthalic acid
Toxicology of terephthalic acid (2008)
Terephthalic and Isophthalic Acids from can coatings (2000)

Tetrabromobisphenol A
Tetrabromobisphenol A - review of toxicological data (2004)

Tetrachloroethylene
Tetrachloroethylene and the reproductive health of workers in the dry-cleaning industry (1997)

Tobacco
Re-assessment of the toxicological testing of tobacco (2004)

Total diet study
2006 Total Diet Study - metals and other elements (2008)
2000 Total Diet Study - 12 metals and other elements (2004)
1999 Total Diet Study - Arsenic in food (2003)
1997 Total Diet Study - Fluorine, Bromine, and Iodine (2000)

Toxicogenomics
Use of toxicogenomics data in risk assessment (2012)
Joint statement of the use of toxicogenomics in toxicology (2004)

Tryptophan
Tryptophan And The Eosinophilia-Myalgia Syndrome (2004)

^Top


Uranium
Uranium levels in water used to reconstitute infant formula (2006)

^Top


Vitamin A
High levels of vitamin A in the infant diet. (2013)

Vitamin B6
Vitamin B6 (pyridoxine) toxicity (1997)


Water
Uranium levels in water used to reconstitute infant formula (2006)
Chlorinated water and reproductive outcomes (2004)
Chlorinated drinking water and reproductive outcomes (1999)

More in this section