COT Agenda and Papers: 13 May 2014

Agenda and papers for the meeting of the Committee at 10:00am on Tuesday 13 May 2014 in conference rooms 4 and 5 AVH 125 Kingsway, London WC2B 6NH


1. Apologies for absence

2. Draft minutes of previous meeting TOX/MIN/2014/02

3. Matters arising

4. Assessment of the adequacy of the 10-fold uncertainty factor to allow for interspecies variation in developmental toxicity. At the December 2013 meeting, the Committee concluded that there were strong indications that the 10-fold uncertainty factor for interspecies variation in developmental toxicity, applied to the most sensitive of either rats or rabbits, was not always adequate. This paper provides additional information requested by the Committee. TOX/2014/17

5. Domoic acid (DA) in King Scallops (Pecten Maximus) processed in Scotland. The Committee was asked to consider the available evidence to support shucking as a scientifically robust and effective method for managing the health risks associated with Amnesic Shellfish Poison (ASP) toxins in scallops at its March 2014 meeting. Members requested further analysis of the available data to explore the possibility of identifying an upper level for DA and epi-DA in whole scallops, at which consumption of a large portion of the shucked product would not result in intakes that exceeded the acute reference dose. TOX/2014/18

6. Scoping paper on potential risks from polybrominated diphenyl ethers (PBDEs) in the infant diet. The Committee has been asked to provide advice on toxicity of chemicals in the infant diet, in support of a review by the Scientific Advisory Committee on Nutrition (SACN) of Government recommendations on complementary and young child feeding. This paper provides information on PBDEs and asks COT to advise on the approach to be taken for this topic TOX/2014/19

7. SACN Review of vitamin D. Adverse effects of high levels. Additional information on single dose vitamin D and changes in serum 25(OH)D levels TOX/2014/20

8. Third arm results from FSA-funded research study T05029 - the effect of soy phytoestrogen supplementation on thyroid status and cardiovascular risk markers in patients with subclinical hypothyroidism: a randomized double blind crossover study. RESERVED BUSINESS TOX/2014/21

9. Paper for information: FSA Scientific Advisory Committees (SACs) update TOX/2014/22

10. Any other business

Date of next meeting – 1 July 2014, Conference Rooms 4 &5, Aviation House, 125 Kingsway, London WC2 6NH

May 2014