COT Agenda and Papers: 29 October 2013

Agenda and papers for the meeting of the Committee at 10:00am on Tuesday 29 October in conference rooms 4 and 5 AVH 125 Kingsway, London WC2B 6NH

Agenda

1. Apologies for absence

2. Draft minutes of the meeting held on 17th September 2013 TOX/MIN/2013/05

3. Matters arising

4. Exposure Monitoring of the Aircraft Cabin Environment. The Department for Transport (DfT) has asked the Committee on Toxicity (COT) to undertake an independent scientific review of the results of DfT-funded aircraft cabin environment research commissioned in response to recommendations made by COT in 2007. This discussion follows on from consideration of a discussion paper at the 17th September meeting. TOX/2013/38

5. Scoping paper on potential risks from perfluorooctane sulfonate (PFOS) in the infant diet. The Committee on Toxicity (COT) has been asked to consider aspects related to diet and the risk of development of food allergic or atopic disease in addition to the toxicity of chemicals in food, in support of a review by the Scientific Advisory Committee on Nutrition (SACN) of Government recommendations on complementary and young child feeding. TOX/2013/40

6. Second draft statement of potential risks of α-, β- and γ- hexachlorocyclohexanes in infant diet. In contribution to the SACN review of UK Government recommendations on complementary and young child feeding, the COT is considering potential risks from isomers α- and β-hexachlorocyclohexane and lindane (γ- hexachlorocyclohexane) in infant nutrition. The Committee is asked to comment on the second draft statement. TOX/2013/41

7. Third draft statement on the potential risks from high levels of soya phytoestrogens and soya products in the infant diet. In contribution to the SACN review of UK Government recommendations on complementary and young child feeding, the COT is considering potential risks from soya phytoestrogens and soya products in the infant diet. The Committee is asked to comment on the third draft statement. TOX/2013/43

8. Presentation on the adequacy of testing methods for juveniles By Professor Aldert Piersma, National Institute for Public Health and the Environment RIVM, The Netherlands.

9. Assessment of the adequacy of the 10-fold uncertainty factor to allow for interspecies variation in developmental toxicity. The Committee agreed that it would be useful to investigate the possibility of evaluating the adequacy of the 10-fold uncertainty factor for interspecies variation discussed in relation to developmental toxicity at the February 2012 and 2013 COT meetings. TOX/2013/42

10. FSA funded research: T01054 Determination of the symptoms of aspartame in subjects who have reported symptoms in the past compared to controls: a pilot double blind placebo crossover study. RESERVED BUSINESS. TOX/2013/39

11. Any other business

12. Date of next meeting – 10th December 2013, Conference Rooms 4 &5, Aviation House, 125 Kingsway, London WC2 6NH