COT Meeting : 30 June 2015

Last updated:
16 June 2015
Agenda and papers for the meeting of the Committee at 10.00am on Tuesday, 30th June 2015 in Conference Rooms 4 & 5, Aviation House, 125 Kingsway, London WC2 6NH


1.  Apologies for absence

2.  Draft minutes of previous meeting TOX/MIN/2015/02

3.  Matters arising

  • Matters arising: Submissions for the reformulation of nonivamide (PAVA) and 2-chlorobenzylidene malononitrile (CS) as irritant sprays. RESERVED BUSINESS  TOX/2015/15

4.  Further submission for the reformulation of 2-chlorobenzylidene malononitrile (CS) as an irritant spray. The Home Office Centre for Applied Science and Technology (CAST) has received a further submission for the reformulation of 2-chlorobenzylidene malononitrile (CS) using a new non-flammable solvent, trioctyl phosphate, and has asked for it to be referred to the COT for expert advice. RESERVED BUSINESS  TOX/2015/16

5.  Assessment of the safety of the propellant HFC-134a. The Centre for Applied Science and Technology (CAST) at the Home Office has requested that the COT review the safety of a propellant proposed for use in general exposure training sprays used by the police.  RESERVED BUSINESS TOX/2015/17

6.  Review of risks arising from the infant diet and the development of atopic and autoimmune disease: Systematic review A – exclusive/predominant breastfeeding, solid food introduction and risk of developing atopic and autoimmune disease RESERVED BUSINESS TOX/2015/18

7.  Histamine in cheese. This discussion paper provides background information on the issue of histamine in food as well as details of the approach currently taken by the FSA when advising on incidents involving high levels of histamine in cheese, of some of the complicating factors such as potentiation by other biogenic amines, and on the EFSA opinion on biogenic amines in fermented foods. TOX/2015/19

8.  Follow up on the toxicokinetics (TK) workshop. On 18th March 2015 a symposium was held to discuss the effects of obesity on toxicokinetics. The aim was to provide a basis for interpreting Food Standards Agency (FSA)-funded research on biomonitoring of persistent organic pollutants in obese subjects. TOX/2015/20

9. Update on hypoallergenic formula WG (info paper). An ad-hoc Working Group was convened by the FSA to assess the safety and benefit associated with the addition of Lactobacillus rhamnosus GG (LGG) to an extensively hydrolysed infant formula called Nutramigen. RESERVED BUSINESS TOX/2015/21

10.  Paper for information: Aggregate and cumulative risk of pesticides: an on-line integrated strategy (Acropolis). The FSA provided matching funds to co-fund the Food and Environment Research Agency (FERA) as one of the partners involved with the ACROPOLIS project. TOX/2015/22

11.  Paper for information: FSA Scientific Advisory Committees (SACs) update TOX/2015/23

12.  Any other business

Date of next meeting – 8th September 2015, Conference Rooms 4 &5, Aviation House, 125 Kingsway, London WC2 6NH




Final Minutes