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See Also

  • Working Group on Variability and Uncertainty in Toxicology
  • Working Group on Phytoestrogens
  • Working Group on Risk Assessment of Mixtures of Pesticides (WiGRAMP)
  • COT Lowermoor Sub-group
  • Food Intolerance Working Group
  • Peanut Allergy Working Group
  • Working Group on Organophosphates (OPs)

WiGRAMP reference list

References listed in WiG/2000/02 and sent to members etc. after the first meeting (19/12/2000)

1. Abou-Donia MB, Wilmarth KR, Jensen KF, Oehme FW, Kurt TL. Neurotoxicity resulting from co-exposure to pyridostigmine bromide, DEET, and permethrin: implications for gulf war chemical exposures. J Toxicol Env Hlth 1996; 48: 35-65.

2. Anon (1996). Food Quality Protection Act of 1996. Pub L 104-70.

3. Arnold SF, Klotz SM, Collins BM, Vonier PM, Guillette LJ, McLachlan JA. Synergistic activation of estrogen receptor with combinations of environmental chemicals. Science 1996: 272; 1489-1492.

4. Bianchi-Santamaria A, Gobbi M, Cembran M, Arnaboldi A. Human lymphocyte micronucleus genotoxicity test with mixtures of phytochemicals in environmental concentrations. Mutat Res 1997; 388: 27-32.

5. Carter WH and Gennings C. Analysis of chemical mixtures: relating isobolograms to response surfaces. In Toxicology of Chemical Mixtures. Academic Press 1994 pp 643-663.

6. Cassee FR, Groten JP, van Bladeren PJ, Feron VJ. Toxicological evaluation and risk assessment of chemical mixtures. Crit Rev Toxicol 1998; 28: 73-101.

7. Cassee FR, S¿hnel J, Groten JP, Feron VJ. Toxicology of chemical mixtures. In General and Applied Toxicology eds B Ballantyne, TC Marrs and T Syversen. London; Macmillan Reference Ltd, 1999.

8. Cerklewski FL, Forbes RM. Influence of dietary zinc on lead toxicity in the rat. J Nutr 1976; 106: 689-696.

9. Chaturvedi AK. Biochemical and toxicological studies on mixtures of three commonly-used hebicides in mice. Arch Contam Toxicol 1993; 24: 449-454.

10. Clevenger MA, Putzrath RM, Brown SL, Ginevan ME, Derosa CT, Mumtaz MM. Risk assessment of mixtures: a model based on mechanisms of action and interaction. In Risk analysis. Prospects and opportunities edited by C Zervos. New York, Plenum, pp 293-303.

11. Dolara P, Vezzani A, Caderni G, Coppi C, Torricelli F. Genetic toxicity of a mixture of fifteen pesticides commonly found in the Italian diet. Cell Biol Toxicol 1993; 9: 333-243.

12. Dolara P, Torricelli F, Antonelli N. Cytogenetic effects on human lymphocytes of a mixture of fifteen pesticides commonly used in Italy. Mutation Res 1994; 325: 47-51.

13. Gaughan LC, Engel J, Casida J (1980). Pesticide interactions: effects of organophosphorous pesticides on the metabolism, toxicity and persistence of selected pyrethroid insecticides. Pestic Biochem Physiol 1980; 14: 81-85.

14. Guigas C, Pool-Zobel BL, Diehl JF. Pr¿fung auf Kombinationseffekte von Quercetin mit den Herbiziden Atrazin, Cyanazin und Gesamprim in Mutagenit¿tstests. Zeitschr Ern¿hrungswissensch 1993; 32: 131-138.

15. Hasegawa R, Tanaka H, Tamano S, Shirai T, Nagao M, Sugimura T, Ito N. Synergistic enhancement of small and large intestinal carcinogenesis by combined treatment of rats with five heterocyclic amines in a medium-term mult-organ bioassay. Carcinogenesis 1994; 15: 2567-2573.

16. Heindel JJ, Chapin RE, Gulati DK, George JD, Price CJ, Marr MC, Myers CB, Barnes LH, Fail PA, Grizzle TB, Schwetz BA, Yang RSH. Assessment of the reproductive and developmental toxicity of pesticide/fertilizer mixtures based on confirmed pesticide contamination in California and Iowa ground water. Fund Appl Toxicol 1994; 22: 605-621.

17. Heindel JJ, Chapin RE, George JD, Gulati DK, Fail PA, Barnes LH, Yang RSH. Assessment of the reproductive toxicity of a complex mixture of 25 groundwater contaminants in mice and rats. Fund Appl Toxicol 1995; 25: 9-19.

18. Instit¿ris L, Siroki O, ¿ndeger ¿, D¿si I, Nagymajtenyi L. Immunotoxicological effects of repeated combined exposure by cypermethrin and the heavy metals lead and cadmium in rats. Int J Immunopharm 1999; 21: 735-743.

19. Ito N, Hasegawa R, Imaida K, Kurata Y, Hahiwara A, Shirai T. Effect of ingesting 20 pesticides in combination at acceptable daily intake levels in rat liver carcinogenesis. Food Chemical Toxicology 1995; 33: 159-163.

20. Ito N, Hagiwara A, Tamano S, Futacuchi M, Imaida K, Shirai T. Effects of pesticide mixtures at the acceptable daily intake levels in rat carcinogenesis. Food Chemical Toxicology 1996; 34: 1091-1096.

21. Jonker D, Woutersen RA, van Bladeren PJ, Til HP, Feron VJ. 4-week oral toxicity study of a combination of eight chemicals in rats: comparison with the toxicity of the individual compounds. Fd Chem Toxicol 1990; 28: 623-631.

22. Jonker D, Jones MA, van Bladeren PJ, Woutersen RA, Til HP, Feron VJ. Acute (24h) toxicity of a combination of four nephrotoxicants in rats compared with the toxicity of individual compounds. Fd Chem Toxicol 1993a; 31: 45-52.

23. Jonker D, Woutersen RA, van Bladeren PJ, Til HP, Feron VJ. Subacute (4-wk) oral toxicity of a combination of four nephrotoxins in rats: comparison with the toxicity of the individual compounds. Fd Chem Toxicol 1993b; 31: 125-136.

24. Kligerman AD, Chapin RE, Erexson GL, Germolec DR, Kwanyuen P, Yang RSH. Analyses of cytogenetic damage in rodents following exposure to simulated groundwater contaminated with pesticides and a fertilizer. Mutat Res 1993; 300: 125-134.

25. Krishnan K, Andersen ME, Clewell HJ, Yang RSH. Physiologically based pharmacokinetic modeling of chemical mixtures. In Toxicology of Chemical Mixtures. Academic Press 1994 pp 399-

26. Kodell RL, Krewski D, Zielinski JM. Additive and multiplicative relative risk in the two-stage clonal expansion model of carcinogenesis. Risk Anal 1991; 11: 483-490.

27. McLachlan JA. Synergistic effect of environmental estrogens: report withdrawn. Science 1997; 277: 462-463.

28. Marinovich M, Guizzetti M, Galli CL. Mixtures of benomyl, pirimiphos-methyl, dimethoate, diazinon and azinphos-methyl affect protein synthesis in HL-60 cells differently. Toxicology 1994; 94: 173-185.

29. Marinovich M, Ghilardi M, Galli CL. Effect of pes ticide mixtures on in vitro nervous cells: comparison with single pesticides. Toxicology 1996; 108: 201-206.

30. Marshall M, Arnott M, Jacobs M, Griffin A. Selenium effcts on the carcinogenicity and metabolism of 2-acetylaminofluorene. Cancer Lett 1979; 7: 331-338.

31. Mumtaz (1995). Risk assessment of chemical mixtures from a public health perspective. Toxicol Lett 1995; 82/83: 527-532.

32. Mumtaz MM, Durkin PR. A weight-of-evidence approach for assessing interactions in chemical mixtures. Toxicol Industr Hlth 1992; 8: 377-406.

33. Mumtaz MM, Hertzberg RC. The status of interactions data in risk assessment of chemical mixtures. In Hazard assessment of chemicals Vol 8, edited by J Saxena. Hemisphere, Washington DC, 1993, pp 47-79.

34. Mumtaz MM, Poirier KA and Colman JT (1997). Risk assessment for chemical mixtures: fine-tuning the hazard index approach. J Clean Technol Environ Toxicol Occup Med 1997; 6: 189-204.

35. Oscarsson A and Lind B. Increased lead levels in brain after long-term treatment with lead and dithiocarbamate and thiuram derivatives in rats. Acta Pharmacol Toxicol 1985; 56: 309-315.

36. Piatti E, Marabini L, Chiesara E. Increase of micronucelus frequency in cultured rat hepatocytes treated in vitro with benomyl and pirimiphos-methyl separately and in mixture. Mutat Res 1994; 324: 59-64

37. Paulet G. L'intoxication cyanhydrique et son traitement. Masson, Paris. 1960

38. Ramamoorthy K, Wang F, Chen I-C, Norris JD, McDonnell DP, Leonard LS, Gaido KW, Bocchinfuso WP, Korach KS, Safe S. Estrogenic acitivity of a dieldrin/toxaphene mixture in the mouse uterus, MCF-7 human breast cancer cells, and yeast-based estrogen receptor assays: no apparent synergism. Endocrinology 1997; 138: 1520-1527.

39. Roloff BD, Belluck DA, Meisner LF. Cytogenetic studies of herbicide interactions in vitro and in vivo using atrazine and linuron. Arch Environ Contam Toxicol 1992; 22: 267-271.

40. Seed J, Brown RP, Olin SS, Foran JA. Chemical mixtures: current risk assessment methodologies and future directions. Regul Toxicol Pharmacol 1995; 22: 76-94.

41. Stelzer A, Chan HM. The relative estrogenic activity of technical toxaphene mixture and two individual congeners. Toxicology 1999; 138: 69-80.

42. Takahashi H, Kato A, Yamashita E, Naito Y, Tsuda S, Shirasu Y. Potentiations of N-methylcarbamate toxicities by organophosphorus insecticides in male mice. Fund Appl Toxicol 1987; 8: 139-146.

43. Taets C, Aref S, Rayburn AL. The clastogenic potential of triazine herbicide combinations found in potable water supplies. Env Hlth Perspect 1998; 106: 197-201.

44. USEPA. United States Environmental Protection Agency. Guidelines for the health risk assessment of chemical mixtures. Fed Reg 1986; 51: 34014-34025

45. van Birgelen APJM, Fase KM, van der Kolk J, Poiger H, Brouwer A, Seinen W, van den Berg M. Synergistic effect of 2,2',4,4',5,5'-hexachlorobiphenyl and 2,3,7,8-tetrachlorodibenzo-p-dioxin on hepatic porphyrin levels in the rat. Environmental Hlth Perspect 1996; 104: 550-557.

46. van Zorge JA. Exposure to mixtures of chemical substances: is there a need for regulations. Food Chemical Toxicol 1996; 34: 1033-1036.

47. Varga T, Hlubik I, V¿nagy L, Budai P, Moln¿r E. Embryonic toxicity of insecticide Sumithion 50 EC and herbicide Fusilade S in pheasants after individual or combined administration. Acta Veterin Hungarica 1999; 38: 329-334

REFERENCES DISCUSSED AT THE FIRST WIGRAMP MEETING (19/12/2000) AND ALSO SENT TO MEMBERS ETC AFTERWARDS.

48. Renwick A G et al. Compounds Sharing the Same Mechanisms of Action/Combination Toxicology (unpublished paper?)

49. A Framework for Cumulative Risk Assessment. An ILSI Risk Science Institute Workshop Report

50. ILSI Health and Environmental Sciences Institute. Risk Assessment Methodology Technical Committee. Aggregate Exposure Assessment: Model Evaluation and Refinement Workshop - Draft Report 11/02/00

51. Aggregate Exposure Assessment. An ILSI Risk Science Institute Workshop Report.

52. Guidance For Identifying Pesticide Chemicals And Other Substances That Have A Common Mechanism Of Toxicity (January 29, 1999)

53. Proposed Guidance on Cumulative Risk Assessment of Pesticide Chemicals That Have a Common Mechanism of Toxicity (Public Comment Draft). Office of Pesticide Programs. U.S. Environmental Protection Agency Washington D. C. 20460

54. Guidance For Performing Aggregate Exposure and risk Assessments Office of Pesticide Program Environmental Protection Agency (October 29, 1999.)

55.Guidance for refining Anticipated Residue Estimates for use in Acute Dietary Probabilistic Risk Assessment U.S. Environmental Protection Agency Office of Pesticide Programs (June 15, 2000)

56. Office of Pesticide Programs. FQPA - Food Safety Advisory Committee Risk Issues subgroup. Aggregate Exposure and common mode of Action

57. 'Effects of combinations of pesticides: a survey of literature/prepared by G Kimmerle, K Hanson, H Hollander - Deutche Forschungmeinschaft (German Research Association) 1975'

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