COT

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COT Secretariat
Food Standards Agency
Aviation House
125 Kingsway
London WC2B 6NH

Tel: 020 7276 8522
Fax: 020 7276 8513

cot@foodstandards.gsi.gov.uk

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COT statements

These statements are the main form in which the Committee presents its advice. They can be viewed by topic or by year.

By topic

By year

Acid sweets:
Adverse reactions to acid sweets (2004)

Additives
Research project (TO7040) investigating the mixtures of certain food colours and a preservative on behaviour in children (2007)

Food additives and developmental neurotoxicity (2006)

Research project investigating the effect of food additives on behaviour (2002)

Amnesic shellfish poisoning
Amnesic shellfish poisoning (2001)

Arsenic
Arsenic in food: results of the 1999 total diet study (2003)

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Bisphenols
Study of bisphenols in canned foods (2001)
Bisphenol A (1997)
Bisphenol A diglycidyl ether (BADGE) in canned foods (1997)

Breast implants
Further toxicity studies in the rat of a hydrogel filler for breast implants (2006)
Further toxicity study in the rat of a hydrogel filler for breast implants (2002)
Toxicity study in the rat of a hydrogel filler for breast implants (2000)

Breast milk
Toxicological evaluation of chemical analyses carried out as part of a pilot study for a breast milk archive (2004)
Health hazards of polychlorinated biphenyls (1997)

Bromine
Organic chlorinated and brominated contaminants in shellfish, farmed and wild fish (2006)
Brominated flame retardants in fish from the Skerne-Tees rivers system (2004)
Tetrabromobisphenol A - review of toxicological data (2004)
1997 Total Diet Study - Fluorine, Bromine, and Iodine (2000)

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Cabin air environment
Review of the cabin air environment, ill-health in aircraft crews and the possible relationship to smoke/fume events in aircraft (2007)

Caffeine
Reproductive effects of caffeine (2001)

Chlorine
Chlorination disinfection by-products and risk of congenital anomalies in England and Wales (2008)
Organic chlorinated and brominated contaminants in shellfish, farmed and wild fish (2006)
Chlorinated water and reproductive outcomes (2004)
Chlorinated drinking water and reproductive outcomes (1999)
Safety-in-use of chlorine and chlorine dioxide as flour treatment agents (1996)

Contaminants
Organic chlorinated and brominated contaminants in shellfish, farmed and wild fish (2006)

Crop spraying
Crop spraying and the health of residents and bystanders (2006)

2-Chlorobenzylidene Malonitrile (CS spray)
Combined exposure to 2-Chlorobenzylidene Malonitrile (CS) and PAVA (Nonivamide) sprays (2006)
2-chlorobenzylidene malononitrile and CS spray (1999)

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Diethyl-m-toluamide (DEET)
Review of toxicology literature on the use of topical insect repellent diethyl-m-toluamide (DEET) update (2006)
Review of toxicology literature on the use of topical insect repellent diethyl-m-toluamide (DEET) (2002)

Dental amalgam
Toxicity of dental amalgam (1998)
Toxicity of dental amalgam (1997)

Developmental neurotoxicity
Food additives and developmental neurotoxicity (2006)

Diet-drug interactions
COT/CSM one day meeting on diet-drug interactions (2006)

Dioxins
FSA funded study investigating the developmental effects of dioxin (TCDD) in rats (2007)
2005 WHO equivalency factors for dioxins and dioxin-like compounds (2006)
Tolerable daily intake for dioxins and dioxin-like polychlorinated biphenyls (2001)
Dietary exposure to dioxins and dioxin-like PCBs (2000)
Dioxins and dioxin-like PCBs in free-range eggs (2000)

Disinfectants
Chlorination disinfection by-products and risk of congenital anomalies in England and Wales (2008)
Commercial survey investigating the occurrence of disinfectants and disinfection by-products in prepared salads (2006)

Domoic acid
Amnesic shellfish poisoning (2001)

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Eggs
Dioxins and dioxin-like PCBs in free-range eggs (2000)

Epigenetics
Workshop on transgenerational epigenetics (2008)

Fish and shellfish
Organic chlorinated and brominated contaminants in shellfish, farmed and wild fish (2006)
Brominated flame retardants in fish from the Skerne-Tees rivers system (2004)
Survey of mercury in fish and shellfish update (2004)
Survey of mercury in fish and shellfish (2003)
Tetrabromobisphenol A - review of toxicological data (2004)
Amnesic shellfish poisoning (2001)
Results of a survey for PCDDs, PCDFs and PCBs in Marine Fish and Fish Products (1999)
Surveillance for malachite green and leucomalachite green in farmed fish (1999)

Fluorine
Fluorine in the 1997 Total Diet Study (2003)
1997 Total Diet Study - Fluorine, Bromine, and Iodine (2000)

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Genetic modification
Studies of potatoes genetically modified to produce Galanthus nivalis lectin (2000)
Studies of potatoes genetically modified to produce Galanthus nivalis lectin (1999)

Genomics and Proteomics
Symposium on the use of Genomics and Proteomics in Toxicology (2002)

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Hexachlorobutadiene
Hexachlorobutadiene (2000)

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Infant food and formulae
Uranium levels in water used to reconstitute infant formula (2006)
Metals in infant food (2003)
Phthalates in infant formulae (1996)

Iodine
1997 Total Diet Study - Fluorine, Bromine, and Iodine (2000)
Iodine in cows' milk (2000)
Iodine in cows' milk (1997)

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Landfill sites
Study by the Small Area Health Statistics Unit (SAHSU) on health outcomes in populations living around landfill sites (2002)
study by the Small Area Health Statistics Unit (SAHSU) on health outcomes in populations living around landfill sites (2001)

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Malachite green
Surveillance for malachite green and leucomalachite green in farmed fish (1999)

Male reproduction
Development and function in adulthood of the human male reproductive system - potential chemical-induced effects (2006)
Male reproduction (2004)

Marine biotoxins
Risk assessment of marine biotoxins of the okadaic acid, pectenotoxin, azaspiracid and yessotoxin groups in support of human health (2006)

Mercury
Survey of mercury in fish and shellfish update (2004)
Survey of mercury in fish and shellfish (2003)
Toxicity of dental amalgam (1998)
Toxicity of dental amalgam (1997)

Metals
2000 Total Diet Study - 12 metals and other elements (2004)
Metals in infant food (2003)
Results of a multi-element survey of fungi and blackberries (2000)
Results of multi-element surveys (1998)

Milk
Toxicological evaluation of chemical analyses carried out as part of a pilot study for a breast milk archive (2004)
Iodine in cows' milk (2000)
Iodine in cows' milk (1997)
Health hazards of polychlorinated biphenyls (1997)

Multi-element surveys
Results of a multi-element survey of fungi and blackberries (2000)
Results of multi-element surveys (1998)

Mycotoxins
Surveillance for the mycotoxin moniliformin (1998)
Surveillance for the mycotoxin sterigmatocystin (1998)

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Nanomaterial toxicology
Addendum to Joint statement on nanomaterial toxicology (2007)
Joint statement on nanomaterial toxicology (2005)

Nitrate metabolism
Nitrate metabolism in man (1999)

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Ochratoxin A
Ochratoxin A on dried vine fruits (1997)

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Paralytic shellfish poisoning (PSP)
Risk assessment and monitoring of paralytic shellfish poisoning (PSP) toxins in support of human health (2006)

Parathyroid hormone axis
Phosphate and the calcium parathyroid hormone axis (2005)

PAVA (Nonivamide)
Combined exposure to 2-Chlorobenzylidene Malonitrile (CS) and PAVA (Nonivamide) sprays (2006)
Joint statement on 2-chlorobenzylidene malononitrile and CS spray (1999)

Perfluorooctane
Tolerable daily intake for perfluorooctane sulfonate (2006)
Tolerable daily intake for perfluorooctanoic acid (2006)

Phthalates
Phthalates in infant formulae (1996)

Pine bark
Supplements containing French maritime pine bark extracts (1999)

Polycyclic Aromatic Hydrocarbons (PAHs)
Polycyclic Aromatic Hydrocarbons - interim pragmatic guideline limits for use in emergencies (2001)

Polychlorinated dibenzo-p-dioxins (PCDDs), Polychlorinated dibenzofurans (PCDFs) and Polychlorinated biphenyls (PCBs)
Tolerable daily intake for dioxins and dioxin-like polychlorinated biphenyls (2001)
Dietary exposure to dioxins and dioxin-like PCBs (2000)
Dioxins and dioxin-like PCBs in free-range eggs (2000)
Results of a survey for PCDDs, PCDFs and PCBs in Marine Fish and Fish Products (1999)
Health hazards of polychlorinated biphenyls (1997)

Pharmacokinetic modelling
Physiologically based pharmacokinetic modelling (2003)

Phenol
Phenol: tolerable daily intake (oral) (2002)

Phytoestrogens
Phytoestrogens (1996)

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Reproduction
Development and function in adulthood of the human male reproductive system - potential chemical-induced effects (2006)
Male reproduction (2004)
Chlorinated water and reproductive outcomes (2004)
Reproductive effects of caffeine (2001)
Chlorinated drinking water and reproductive outcomes (1999)
Tetrachloroethylene and the reproductive health of workers in the dry-cleaning industry (1997)

Risk assessment
COT workshop on evolving approaches to chemical risk assessment (2007)
Risk assessment of marine biotoxins of the okadaic acid, pectenotoxin, azaspiracid and yessotoxin groups in support of human health (2006)
Risk assessment and monitoring of paralytic shellfish poisoning (PSP) toxins in support of human health (2006)

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Salatrims / Structured triglycerides
Consideration of toxicological data for some structured triglycerides (Salatrims) composed of mixtures of short and long chain fatty acids (2000)
Toxicological aspects of a submission on Salatrims, for ACNFP (1999)
Salatrims for ACNFP (1997)

Shellfish
Organic chlorinated and brominated contaminants in shellfish, farmed and wild fish (2006)
Risk assessment of marine biotoxins of the okadaic acid, pectenotoxin, azaspiracid and yessotoxin groups in support of human health (2006)
Risk assessment and monitoring of paralytic shellfish poisoning (PSP) toxins in support of human health (2006)
Brominated flame retardants in fish from the Skerne-Tees rivers system (2004)
Tetrabromobisphenol A - review of toxicological data (2004)
Survey of mercury in fish and shellfish (2003)
Amnesic shellfish poisoning (2001)

Sterigmatocystin
Results of a survey for Sterigmatocystin in foodstuffs (2000)
Surveillance for the mycotoxin sterigmatocystin (1998)

Supplements
Supplements containing French maritime pine bark extracts (1999)

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Terephthalic
Toxicology of terephthalic acid (2008)
Terephthalic and Isophthalic Acids from can coatings (2000)

Tetrabromobisphenol A
Tetrabromobisphenol A - review of toxicological data (2004)

Tetrachloroethylene
Tetrachloroethylene and the reproductive health of workers in the dry-cleaning industry (1997)

Tobacco
Re-assessment of the toxicological testing of tobacco (2004)

Total diet study
2000 Total Diet Study - 12 metals and other elements (2004)
1999 Total Diet Study - Arsenic in food (2003)
1997 Total Diet Study - Fluorine, Bromine, and Iodine (2000)

Toxicogenomics
Joint statement of the use of toxicogenomics in toxicology (2004)

Tryptophan
Tryptophan And The Eosinophilia-Myalgia Syndrome (2004)

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Uranium
Uranium levels in water used to reconstitute infant formula (2006)

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Vitamin B6
Vitamin B6 (pyridoxine) toxicity (1997)

Water
Uranium levels in water used to reconstitute infant formula (2006)
Chlorinated water and reproductive outcomes (2004)
Chlorinated drinking water and reproductive outcomes (1999)

COT statements by year
These statements are the main form in which the Committee presents its advice.

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