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Symposium on Genomics and Proteomics: October 8, 2001

The use of genomics and proteomics has been identified as a suitable topic for a joint meeting between the COT, COC and COM, because it is a rapidly growing area with important implications for toxicological risk assessment and will have implications in the regulatory area.

These technologies are already being used extensively and recent papers have highlighted examples of possible applications of this knowledge.

Meeting objectives

The objectives of the meeting are:

• To provide advice to government departments and regulatory agencies on use of genomics and proteomics in toxicological risk assessment
• To facilitate closer working and greater collaboration between the COT, COC and COM.

Strategy for Meeting

In order to help Members prepare, the secretariat has collated abstracts for presentations to the working groups, a bibliography and a glossary of useful terms. A number of selected references has been provided as background information.

• Session 1. Introduction to the use of genomics/proteomics in toxicology. An overview presentation by Dr G Orphanides (Syngenta) will be followed by a brief introduction from each of the Working Groups. (Chaired by Professor Woods, Chair COT.)
• Session 2. Members will attend one of three Working Groups. A number of questions have been suggested by the secretariat for each of the WGs (see papers below) in order to help stimulate discussion.
• Session 3. Professor Blain (Chair COC) will chair a discussion of the outcome from each of the WGs (to be presented by the Facilitators). A number of overall conclusions will be drawn regarding the current and potential future uses of genomics and proteomics in toxicology and areas where further research and development are required.

Post meeting

The Secretariat will prepare a detailed report for consideration by the Committees. It is envisaged that the report will be published in a peer reviewed journal. A statement containing the main conclusions will also be published on the Committees' websites.

Meeting summary
Joint meeting of the COT/COC/COM to discuss the use of genomics and proteomics in risk assessment.

Genomics, Transcriptomics and Proteomics: Glossary of Terms
A glossary for the terms used in this seminar.

Joint Statement on the Symposium
Joint Statement on a Symposium on the use of genomics and proteomics in toxicology.

Programme
Monday 8 October 2001 at the Department of Health, Skipton House, 80 London Road, London SE1 6LH.

References
A set of references for the seminar documents.

Session 1: Presentation
Dr George Orphanides of the Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire, on The Use of Genomics and Proteomics in Toxicology.

Working Group 1: Use of Genomics in Screening
Speaker: Dr Valerie Baker Facilitator: Dr Philip Carthew

Working Group 2: Use of proteomics in screening
Speaker: Dr Cliff Elcombe Facilitator: Dr Sandy Kennedy

Working Group 3: Use of Genomics and Proteomics in Risk Assessment
Speaker - Dr Tim Gant Facilitator - Dr Andy Smith

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